Lead current reduction in a three phase four wires Shunt Hybrid Filter

Peer ReviewedPostprint (author’s final draft

RECLAMO: virtual and collaborative honeynets based on trust management and autonomous systems applied to intrusion management

Security intrusions in large systems is a problem due to its lack of scalability with the current IDS-based approaches. This paper describes the RECLAMO project, where an architecture for an Automated Intrusion Response System (AIRS) is being proposed. This system will infer the most appropriate response for a given attack, taking into account the attack type, context information, and the trust and reputation of the reporting IDSs. RECLAMO is proposing a novel approach: diverting the attack to a specific honeynet that has been dynamically built based on the attack information. Among all components forming the RECLAMO's architecture, this paper is mainly focused on defining a trust and reputation management model, essential to recognize if IDSs are exposing an honest behavior in order to accept their alerts as true. Experimental results confirm that our model helps to encourage or discourage the launch of the automatic reaction process

p27(Kip1) expression as a prognostic marker for squamous cell carcinoma of the head and neck

Regulation of the cell cycle is essential for carcinogenesis. The cell cycle is controlled by cyclin-dependent kinases (CDKs), which are upregulated by cyclins and downregulated by CDK inhibitors (CDKIs). Decreased p27(Kip1) expression has been associated with survival rate, tumor size, histological differentiation and the presence of lymph node metastasis in patients with various types of cancer. The aim of the current study is to provide a literature review on the association between p27(Kip1) expression and the clinical and pathological aspects of head and neck squamous cell carcinoma (HNSCC), and the expression of other CDKIs of the Cip/Kip family and cyclins. Throughout the literature, different methodologies were used to determine the immunohistochemical expression of p27(Kip1); thus, results concerning p27(Kip1) expression in HNSCC vary widely. However, it has now been confirmed that p27(Kip1) is underexpressed in SCC cells. p27 may be a promising marker for determining the prognosis of HNSCC, despite the marked variability of the results obtained. An association between p27 expression and survival rate, time to recurrence and tumor stage has been observed. Based on the information currently available, it is premature to recommend the analysis of p27(Kip1) expression in guiding HNSCC treatment planning. However, although relatively unstudied, the correlation between p27(Kip1) expression and other tumor suppressor genes may turn out to be important in determining the prognosis of HNSCC. Further prospective studies utilizing standardized laboratory methodologies and statistics that facilitate meta-analyses are required to confirm this proposal

Design and Development of a Multimodal Vest for Virtual Immersion and Guidance

This paper is focused on the development of a haptic vest to enhance immersion and realism in virtual environments, through vibrotactile feedback. The first steps to achieve touch-based communication are presented in order to set an actuation method based on vibration motors. Resulting vibrotactile patterns helping users to move inside virtual reality (VR). The research investigates human torso resolution and perception of vibration patterns, evaluating different kind of actuators at different locations on the vest. Finally, determining an appropriate distribution of vibration patterns allowed the generation of sensations that, for instance, help to guide in a mixed or virtual reality environment

Ciencia, política y poder

Science is, for decades now, a social enterprise. Most of the scientific research in the Western world is no longer in the hands of single individuals who work alone using their own resources, but depends on the coordinated activity of many professionals. Moreover, contemporary science requires sustained funding that provides technological and human support. In our environment, this funding comes mainly from public resources, which in turn requires adequate management of them. However, the fundamental question for some of our fellow citizens remains: what is science for?Hacer ciencia es, desde hace ya décadas, una em- presa social. La mayor parte de la investigación científica en el mundo occidental no está ya en manos de personas singulares que trabajan solas utilizando recursos propios, sino que depende de la actividad coordinada de muchos profesionales. Más aún, la ciencia contemporánea exige una financiación sostenida que le dé soporte tecnológico y humano. En nuestro entorno, esta financiación proviene mayoritariamente de recursos públicos, lo que a su vez requiere de una adecuada gestión de los mismos. Sin embargo, la pregunta fundamental para algunos de nuestros conciudadanos sigue siendo: ¿para qué sirve la ciencia

Fragment dissolved molecular dynamics: a systematic and efficient method to locate binding sites

Diverse computational methods to support Fragment-based drug discovery (FBDD) are available in the literature. Despite their demonstrated efficacy to support FBDD campaigns, they exhibit some drawbacks such as protein denaturation or ligand aggregation that have not been yet clearly overcome in the framework of biomolecular simulations. In the present work, we discuss a systematic semi-automatic novel computational procedure, designed to surpass these difficulties. The method, named fragment dissolved Molecular Dynamics (fdMD) utilizes simulation boxes of solvated small fragments, adding a repulsive Lennard-Jones potential term to avoid aggregation, which can be easily used to solvate the targets of interest. This method has the advantage of solvating the target with a low number of ligands, thus preventing this way denaturation of the target, while simultaneously generating a database of ligandsolvated boxes that can be used in further studies. A number of scripts are made available to analyze the results and obtain the descriptors proposed as a means of trustfully discard spurious binding sites. To test our method, four Test cases of different complexity have been solvated with ligand boxes and four molecular dynamics runs of 200 ns length have been run for each system, which have been extended up to 1 µs when needed. The reported results point that the selected number of replicas are enough to identify the correct binding sites irrespective of the initial structure, even in the case of proteins having several close binding sites for the same ligand. We also propose a set of descriptors to analyze the results, among which, the average MMGBSA and the average KDEEP energies emerge as the most robust ones.Peer ReviewedPostprint (author's final draft

Terasense WP03 radiation and sensor measurement lab workpackage

This paper explains the progress accomplished in the WP03 of the Terasense Project (TERAHERTZ TECHNOLOGY FOR ELECTROMAGNETIC SENSING APPLICATIONS) approved in the 2008 CONSOLIDERINGENIO program (project CSD2008-0068). The Radiation and Sensor Measurement Lab (RSMLab) is a laboratory based in the existing antenna measurement laboratories at UPM, UC3 and UNiOvi and the new capacities to extend the measurement range from the millimetre wave to the THz region. This laboratory is intended to be shared in more than one place and with more than one institution, in such a way that we could take advantage of other research financial sources and contributions from other institutions with interest in the same field of measurements. One important task will be the international links between the RSMLab and other European and international institutions dedicated to the antenna and sensor measurement in the same frequency range