Análisis de parámetros de tráfico de voz ip según modelo erlang B, para un punto de acceso wifi-UPAO mediante mediciones realizadas en el laboratorio de telecomunicaciones de la escuela de ingeniería electrónica de la universidad privada Antenor Orrego

La presente investigación se centra en el análisis de parámetros mediante mediciones realizadas en el laboratorio de telecomunicaciones de la escuela de ingeniería electrónica de la Universidad Privada Antenor Orrego de la ciudad de Trujillo Perú, con el fin de estimar la capacidad de tráfico de voz que puede soportar un Access Point de la Red WiFi UPAO. Se presenta el marco teórico correspondiente al modelo de tráfico erlang B para luego presentar los materiales y procedimientos de la investigación. Se hicieron pruebas experimentales para poder realizar llamadas de voz recolectándolas para establecer parámetros que puedan ser contrastados con las estimaciones del modelo teórico. Al terminar las pruebas de llamadas para un AP con 14 usuarios se llega a determinar que el equivalente a Erlang B es de 14 troncales, se hicieron pruebas de llamadas midiendo los tiempos de ocupación, calculando el volumen de tráfico y estimando el tráfico cursado y a partir de las mediciones se obtuvo el equivalente de troncales en Erlang B. Los resultados son discutidos y se presentan finalmente las conclusiones y recomendaciones del trabajo.This research focuses on the analysis parameters measurements carried out in the laboratory telecommunication School of Electronic Engineering Private University Antenor Orrego of the city of Trujillo Peru, in order to estimate the capacity of voice traffic that can Access Point support a WiFi Network UPAO. The corresponding theoretical framework to Erlang B traffic model is presented and present the materials and methods of research. Experimental tests were made to make calls from collecting them to set parameters that can be compared with estimates of the theoretical model voice. To finish tests call for an AP with 14 users will get to determine that the equivalent of Erlang B is 14 trunks, test calls measuring occupation times, calculating the volume of traffic and estimating traffic were coursed and from measurements of the equivalent of stem Erlang B was obtained.The results are discussed and finally presented the findings and recommendations of work

First tests of the applicability of γ\gamma-ray imaging for background discrimination in time-of-flight neutron capture measurements

In this work we explore for the first time the applicability of using $\gamma$-ray imaging in neutron capture measurements to identify and suppress spatially localized background. For this aim, a pinhole gamma camera is assembled, tested and characterized in terms of energy and spatial performance. It consists of a monolithic CeBr$_3$ scintillating crystal coupled to a position-sensitive photomultiplier and readout through an integrated circuit AMIC2GR. The pinhole collimator is a massive carven block of lead. A series of dedicated measurements with calibrated sources and with a neutron beam incident on a $^{197}$Au sample have been carried out at n_TOF, achieving an enhancement of a factor of two in the signal-to-background ratio when selecting only those events coming from the direction of the sample.Comment: Preprint submitted to Nucl. Instr. and Meth.

Randomized clinical trial on the clinical effects of a toothpaste containing extra virgin olive oil, xylitol, and betaine in gingivitis

To determine the effects on gingival bleeding, dental biofilm, and salivary flow and pH in patients with gingivitis of using toothpaste with extra-virgin olive oil (EVOO), xylitol, and betaine in comparison to a placebo or commercial toothpaste. This controlled, double blinded, and multicenter randomized clinical trial included patients with gingivitis randomly assigned to one of three groups: test group (EVOO, xylitol, and betaine toothpaste), control group 1 (placebo toothpaste), or control group 2 (commercial toothpaste). Percentage supragingival biofilm and gingival bleeding were evaluated at baseline (T0), 2 months (T2), and 4 months (T4), measuring non-stimulated salivary flow and salivary pH. Comparisons were performed between and within groups. The final study sample comprised 20 in the test group, 21 in control group 1, and 20 in control group 2. In comparison to control group 1, the test group showed significantly greater decreases in gingival bleeding between T4 and T0 (p = 0.02) and in biofilm between T2 and T0 (p = 0.02) and between T4 and T0 (p = 0.01). In the test group, salivary flow significantly increased between T2 and T0 (p = 0.01), while pH alkalization was significantly greater between T4 and T0 versus control group 2 (p = 0.01) and close-to-significantly greater versus control group 1 (p = 0.06). The toothpaste with EVOO, xylitol, and betaine obtained the best outcomes in patients with gingivitis, who showed reductions in gingival bleeding and supragingival biofilm and an increase in pH at 4 months in comparison to a commercial toothpaste.(STOP ORAL DYSBIOSIS) - University of Granada OTRI-4907Mucosal Innovations S.L. (Madrid

Cytotoxicity of three new triazolo-pyrimidine derivatives against the plant trypanosomatid: Phytomonas sp isolated from Euphorbia characias

There is no effective chemotherapy against diseases caused by Phytomonas sp., a plant trypanosomatid responsible for economic losses in major crops. We tested three triazolo-pyrimidine complexes [two with Pt(II), and another with Ru(III)] against promastigotes of Phytomonas sp. isolated from Euphorbia characias. The incorporation of radiolabelled precursors, ultrastructural alterations and changes in the pattern of metabolite excretion were examined. Different degrees of toxicity were found for each complex: the platinun compound showed an inhibition effect on nucleic acid synthesis, provoking alterations on the levels of mitochondria, nucleus and glycosomes. These results, together with others reported previously in our laboratory about the activity of pyrimidine derivatives, reflect the potential of these compounds as agents in the treatment of Phytomonas sp.Financial support Universidad de Granada (Spain), grant BIO 2000-1429

Nueva especie de microalga y su aplicación para consumo animal, humano y en la obtención de carotenoides

Número de publicación: ES2259548 A1 (01.10.2006) También publicado como: ES2259548 B1 (01.10.2007) Número de Solicitud: Consulta de Expedientes OEPM (C.E.O.)P200500374 (18.02.2005)Una nueva cepa de Scenedesmus ha sido aislada en la estación experimental "Las Palmerillas-CAJAMAR", siendo identificada como "microorganismo no previamente registrado" por la Universidad de Gottinghem, y depositada en la Culture Collection of Alagae and Protozoa (CCAP) como Scenedesmus almeriensis. La nueva cepa puede ser utilizada para consumo animal y/o humano, y produce elevadas cantidades de carotenoides, especialmente luteína y betacaroteno. Scenedesmus almeriensis crece adecuadamente en un amplio rango de temperaturas de 10°C a 40°C, a un pH de 7.0 a 9.5, y es tolerante a elevadas concentraciones de cobre, de hasta 1 mg/L. La cepa microalgal, cultivada en un fotobiorreactor de 4000 L en el que el cultivo se impulsa mecánicamente, produce luteína en una cantidad de al menos 4 mg por gramo de materia seca. Esta cepa es muy adecuada para la producción de carotenoides de aplicación en el tratamiento de desordenes de la macular ocular.Universidad de Almerí

Diseño de fármacos inhibidores de enzimas o sistemas de transporte en la diabetes mellitus tipo II

La diabetes mellitus tipo II (DM2) es un complejo síndrome metabólico que se caracteriza por una hiperglucemia duradera, debida a la escasez en la secreción de insulina y/o a la resistencia a la misma. Respecto al diseño de fármacos inhibidores de enzimas o sistemas de transporte de DM2, las incretinas, hormonas peptídicas segregadas en el intestino como respuesta a la ingesta de alimentos y que presentan un papel crucial en el mantenimiento de la homeostasia de la glucosa, se convirtieron en una posible vía de desarrollo de nuevos fármacos para la DM2. La estrecha relación entre estas hormonas y la dipeptidil dipeptidasa (DPP-4), permitió el desarrollo de diferentes inhibidores de la enzima para la síntesis de nuevos tratamientos. Las cianopirrolidinas como inhibidor peptidomimético, fueron las precursoras en el desarrollo de síntesis de nuevos medicamentos en el arsenal terapéutico, que presentaban ventajas terapéuticas respecto a la incidencia de hipoglucemias, y a la supervivencia de células β-pancreáticas que no trataba ninguna familia terapéutica del momento. Otra familia empleada dentro de los inhibidores no peptidomiméticos, fue los derivados de la β-homofenilalanina como la sitagliptina (Januvia®), que presentó buen perfil farmacocinético y buena selectividad, redujo significativamente la glucosa en sangre y presentó una eficacia superior en la antihiperglucemia y una buena tolerabilidad, siendo la molécula precursora de numerosos estudios para desarrollar análogos

Patients with periodontitis and erectile dysfunction suffer a greater incidence of major adverse cardiovascular events: A prospective study in a Spanish population

DATA AVAILABILITY STATEMENT The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available because of privacy or ethical restrictions.Background Periodontitis and erectile dysfunction (ED) have been linked with cardiovascular disease. The association of periodontitis and ED with the occurrence of major adverse cardiovascular events has not been previously assessed. The aim of this study was to determine if the presence of periodontitis and ED has any effect on the incidence of major adverse cardiovascular events. Methods Male patients that attended the Urology service were enrolled in a prospective study. Erectile dysfunction was diagnosed according to the International Index of Erectile Function. Sociodemographic data and periodontal clinical parameters were gathered (pocket probing depth, clinical attachment loss, bleeding on probing (BoP), plaque index and number of teeth) at baseline. Major adverse cardiovascular events occurred both before and during the follow-up time were registered. Bivariate analyses, as well as a multivariate analysis were performed, adjusting for potential confounders. Results A total of 158 patients were included, with a mean follow-up of 4.2 years. A greater number of major adverse cardiovascular events occurred in the group that presented periodontitis and ED (P = 0.038). After adjusting by age and previous cardiovascular disease in the multivariate analysis, the annual major adverse cardiovascular event rate was estimated to be 3.7 times higher in the same group (P = 0.049). Other periodontal clinical variables together with ED supported these results and were close to statistical significance. Conclusions Patients with periodontitis and ED, adjusted by age and a cardiovascular disease, showed 3.7 times more risk of suffering major adverse cardiovascular events after mean follow-up of 4.2 years.Research Group #CTS-583 (Junta de Andalucía, Granada, Spain

First tests of the applicability of γ-ray imaging for background discrimination in time-of-flight neutron capture measurements

In this work we explore for the first time the applicability of using γ-ray imaging in neutron capture measurements to identify and suppress spatially localized background. For this aim, a pinhole gamma camera is assembled, tested and characterized in terms of energy and spatial performance. It consists of a monolithic CeBr3 scintillating crystal coupled to a position-sensitive photomultiplier and readout through an integrated circuit AMIC2GR. The pinhole collimator is a massive carven block of lead. A series of dedicated measurements with calibrated sources and with a neutron beam incident on a 197Au sample have been carried out at n_TOF, achieving an enhancement of a factor of two in the signal-to-background ratio when selecting only those events coming from the direction of the sample.España, Ministerio de Economía y Competitivdad FPA2011-24553España, Ministerio de Economía y Competitivdad FPA2013-45083-PEspaña, Ministerio de Economía y Competitivdad SEV-2014-039