8 research outputs found

    Synthesis of γ-, Ύ-, and Δ-Lactams by Asymmetric Transfer Hydrogenation of N-(tert-Butylsulfinyl)iminoesters

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    Highly enantiomerically enriched Îł- and ÎŽ-lactams have been prepared by a simple and very efficient procedure that involves the asymmetric transfer hydrogenation of N-(tert-butylsulfinyl)iminoesters followed by desulfinylation of the nitrogen atom and spontaneous cyclization to the desired lactams during the basic workup procedure. Five- and six-membered ring lactams bearing aromatic, heteroaromatic, and aliphatic substituents have been obtained in very high yields and ee’s up to >99%. A slight modification of the procedure also allowed the preparation of Δ-lactams in good yields and very high enantioselectivities. Both enantiomers of the final lactams could be prepared with equal efficiency by changing the absolute configuration of the sulfinyl chiral auxiliary

    Catalytic, One-Pot Synthesis of ÎČ-Amino Acids from α-Amino Acids. Preparation of α,ÎČ-Peptide Derivatives

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    Novel Syntheses of Azetidines and Azetidinones

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