Pulse wave velocity and lipids between GDM and non-GDM based on IADPSG and WHO criteria.

<p>^<b>1</b> Adjusted for age, BMI, and frequency of current and previous smokers.</p><p>Data are given as median (25^th, 75^th).</p><p>Comparison between women with GDM and non-GDM were performed using univariate general linear model on log transformed data.</p><p>Pulse wave velocity and lipids between GDM and non-GDM based on IADPSG and WHO criteria.</p

Predictors of PWV and TG/HDL ratio at 5-year follow-up based on GDM status in the index pregnancy using the WHO diagnostic criteria.

<p>^<b>1</b> Defined as primiparous (for the purposes of the 5-year follow-up)</p><p>^<b>2</b> Refers to both current and previous smokers</p><p>Predictors of PWV and TG/HDL ratio at 5-year follow-up based on GDM status in the index pregnancy using the WHO diagnostic criteria.</p

Relationship between measurements of glycemic control and vascular stiffness at 5-year follow-up in patients with (red circles) and without GDM (green circles) in the index pregnancy.

<p>(A) Associations between PWV, TG/HDL-C ratio and glucose levels during OGTT, HOMA-IR, insulin sensitivity and beta-cell function in the whole cohort at follow-up. (B) Interaction analysis between GDM (red) and indices of glucose metabolism on the TG/HDL ratio. (C) Interaction analysis between BMI and SBP and indices of glucose metabolism on the TG/HDL ratio.</p

MOESM1 of Low circulating pentraxin 3 levels in pregnancy is associated with gestational diabetes and increased apoB/apoA ratio: a 5-year follow-up study

Additional file 1: Table S1. Plasma levels of PTX-3 and CRP during and after pregnancy in normal and GDM pregnancy according to IADSPSG criteria. Table S2. Univariate associations for increased CV risk as reflected by the apoB/apoA, LDL and TG/HDL-C ratios by PTX3, CRP and other CV risk factors at 5 years follow-up. Table S3. Multivariable adjusted models for increased CV risk as reflected by the apoB/apoA, LDL and TG/HDL-C ratios by PTX3 during pregnancy. The adjusted analysis included BMI and systolic BP acquired at the same time as the PTX3 measurement. Figure S1.  ROC curves of  ApoB/apoA and LDL/HDL-C during various time-points in pregnancy and CV risk at 5 years after pregnancy as reflected by the apoB/apoA ratio at 5 years follow-up

Comparison of the effects of substances (VN 004 and VN 009) from derivative of vasicin on model of isolated trachea.

Charles University in Prague Faculty of Pharmacy in Hradec Kralove Department of Pharmacology and Toxicology Candidate: Mgr. Sandra Vrátná Supervisor: PharmDr. Marie Vopršalová, Csc. Name thesis: Comparison of the effects of substances (VN 004 and VN 009) from derivative of vasicin on model of isolated trachea The aim of the thesis was to determine the in vitro activity of relaxing two structural modifications quinazoline alkaloids VN 004 (4- dimetylaminoetylsulfanylchinazolin) and VN 009 (N- [2- (piperidin-1-yl) ethyl] quinazolin-4-amine) on smooth muscle isolated rat trachea. They tested synthetic materials were derived from alkaloids vasicin and vasicinone contained in bushes Adhatoda vasica. On isolated rat trachea we were observed cumulative relaxation effect of single doses of the aforementioned compounds. From the measured values it was clearly evident that these synthetic quinazoline derivatives demonstrated on isolated rat trachea relaxing effect. Derivates with ethylaminfragment VN 009 was less effective derivative, but even so, demonstrated a greater activity than the standard theophylline. Conversely, stronger relaxation effect reported from the second derivatives with ethylsulfanyl fragment VN 004, the value of ED50 was 32.5 times lower than the ED50 of theophylline

Causes of death by 1-year intervals following hospitalization for an episode community-acquired pneumonia.

<p>Abbreviations: COPD, chronic obstructive pulmonary disease. ^a Polyarteritis with lung involvement (Churg-Strauss), sepsis, unspecified infectious disease, urinary tract infection, hypoglycemia, diabetes mellitus with renal complication, tubulo-interstitial nephritis, kidney failure, other non-thrombocytopenic purpura, alcohol dependence syndrome, esophageal ulcer, ileus, cholecystitis, fistula of vagina to large intestine, gastrointestinal hemorrhage, cerebral palsy, motor neuron disease (2 cases), instantaneous or unattended death (2 cases), dementia (3 cases), accident (3 cases).</p

Multivariable analysis of factors associated with long-term mortality after hospitalization for CAP.

<p>Multivariable analysis of factors associated with long-term mortality after hospitalization for CAP.</p

Kaplan-Meier plot of long-term survival for 259 patients discharged from hospital after treatment of community-acquired pneumonia.

<p>One patient was lost to follow-up (censored) at day 1.</p

DataSheet_1_Circulating T Cell Activation and Exhaustion Markers Are Associated With Radiation Pneumonitis and Poor Survival in Non-Small-Cell Lung Cancer.docx

IntroductionPersistent inflammation and immune activation in the lungs are associated with adverse outcomes such as radiation pneumonitis (RP) and poor survival in non-small-cell lung cancer (NSCLC) patients. However, it is unknown how this is reflected by leukocyte activation markers in serum.ObjectiveThe aim was to evaluate the serum levels of activation of different leukocyte subsets and to examine those in relation to the pathogenesis of RP and survival in NSCLC.MethodsWe analyzed the serum levels of MPO, sCD25, sTIM-3, sPD-L1, sCD14, sCD163, CCL19 and CCL21 in 66 inoperable NSCLC patients with stage IA-IIIA disease. The patients were treated with stereotactic body radiation therapy (SBRT) or concurrent chemoradiation therapy (CCRT), followed by regular blood sampling for 12 months after treatment and for 5 years for survival.ResultsNineteen (29%) patients developed RP, which occurred more frequently and earlier in patients receiving CCRT than in those receiving SBRT. Increases in sCD25, sTIM-3 and CCL21 levels were observed at the last 6 months of follow-up in patients who had RP after SBRT. Patients who had RP after CCRT had higher sTIM-3 levels during the first 3 months of follow-up. Baseline sCD25 was independently associated with both 2- and 5-year mortality outcomes, while baseline sTIM-3 was independently associated with 2-year mortality.ConclusionWe showed that T cell activation and exhaustion markers such as sCD25 and sTIM-3 are enhanced in patients developing RP and are associated with poor survival in NSCLC.</p

Risk factors for fatal outcome in malaria patients.

<p>Boldface type indicates statistical significance.</p>1<p>Deaths/number at risk in percentage and proportion.</p>2<p>OR  =  odds ratio.</p>3<p>The p-values are from Mann-Whitney tests.</p>4<p>CI  =  confidence interval.</p>5<p>The adjusted OR and p-values are from binary logistic regression.</p