Ultrasonicated synthesis of some potent antimicrobial aryl sulphonamides

1373-1377Nine N-(2,4-difluorophenyl) substituted benzene sulphonamides have been synthesized by ultrasonication method within short reaction time having more than 90% yield. These sulphonamides have been analyzed by spectral and analytical techniques. The higher yields of sulphonamides have been found to be in case of ultrasonication process as compared to microwave and conventional heating methods. The antimicrobial activities of these sulphonamides have been evaluated using Bauer-Kirby disc diffusion method by means of measurement of mm of zone of inhibition

SiO₂-H₃PO₄ catalyzed condensation of amines and aldehydes: Solvent-free synthesis of some <i>E</i>-imines, spectral correlations of (<i>E</i>)-<i>N</i>-(substituted benzylidene)-1-benzylpiperidin-4-amines and XRD structure of (<i>E</i>)-<i>N</i>-(4-nitrobenzylidene)-1-benzylpiperidin-4-amine<span style="mso-ansi-language:EN-GB" lang="EN-GB"> </span>

779-790A series of Schiff bases (aryl E-imines) including (E)-N-(substituted benzylidene)-1-benzylpiperidin-4-amines have been derived from the SiO2-H3PO4 catalyzed solvent-free condensation of aryl amines including 1-benzylpiperidin amines and substituted benzaldehydes under microwave irradiation. The yields of the imines are more than 85%. The synthesized imines are characterized by their physical constants, analytical and spectroscopic data earlier reported in literature. The group frequencies of imines such as infrared (<span style="font-family:Symbol;mso-ascii-font-family: " times="" new="" roman";mso-hansi-font-family:"times="" roman";mso-char-type:symbol;="" mso-symbol-font-family:symbol"="" lang="EN-GB">v, cm-1), NMR both 1H and 13C chemical shifts (<span style="font-family: Symbol;mso-ascii-font-family:" times="" new="" roman";mso-hansi-font-family:"times="" roman";="" mso-char-type:symbol;mso-symbol-font-family:symbol"="" lang="EN-GB">, ppm) have been correlated with Hammett substituent constants, F and R parameters. The XRD structure of the (E)-N-(4-nitrobenzylidene)-1-benzylpiperidin-4-amine have been established. </span

SOCl2 catalyzed cyclization of chalcones: Synthesis and spectral studies of some bio-potent 1H pyrazoles

Some aryl-aryl 1H pyrazoles have been synthesised by cyclization of aryl chalcones and hydrazine hydrate in the presence of SOCl2. The yields of the pyrazoles are more than 85%. These pyrazoles are characterized by their physical constants and spectral data. The infrared, NMR spectral group frequencies of these pyrazolines have been correlated with Hammett substituent constants, F and R parameters. From the results of statistical analyses the effects of substituent on the spectral frequencies have been studied. The antimicrobial activities of all synthesised pyrazolines have been studied using Bauer-Kirby method. DOI: http://dx.doi.org/10.4314/bcse.v28i2.1

Ultrasonicated synthesis of some potent antimicrobial aryl sulphonamides

Nine N-(2,4-difluorophenyl) substituted benzene sulphonamides have been synthesized by ultrasonication method within short reaction time having more than 90% yield. These sulphonamides have been analyzed by spectral and analytical techniques. The higher yields of sulphonamides have been found to be in case of ultrasonication process as compared to microwave and conventional heating methods. The antimicrobial activities of these sulphonamides have been evaluated using Bauer-Kirby disc diffusion method by means of measurement of mm of zone of inhibition.