Enhancement of Power Quality in Grid Connected Photovoltaic System Using Predictive Current Control Technique

Now- a days the increased use of power electronic devices has resulted in power quality problems such as voltage sag, swell, harmonics and voltage flicker. Non-linear loads affect system power quality. PV systems are grid connected via an interfacing converter. Single phase shunt active power filter (APF) can be used to develop the power quality in terms of current harmonic mitigation and reactive power compensation. In this paper a PV interfacing inverter which acts as a shunt an APF is controlled using predictive current control (PCC) technique for current harmonics mitigation. The MATLAB Simulink model is used to study the performance of system

Mean platelet volume as a predictor of clinical outcomes in patients of acute myocardial infarction

Background: High levels of mean platelet volume (MPV), as an indicator of larger, more reactive platelets resulting from an increased platelet turnover, may represent a risk factor for overall vascular mortality and other cardiovascular events, including myocardial infarction (MI). The present study was undertaken to see the predictive value of MPV in accessing the clinical outcomes in acute myocardial infarction, (AMI).Methods: Total consecutive 114 cases of AMI admitted to intensive care unit were enrolled in the study and were compared with the equal number of age and gender-matched controls. The clinical evaluation of cases was done at admission and on day 7 in terms of a) Cardiogenic shock, b) Arrhythmia and c) Effect of thrombolysis. Patients were classified according to tertile of baseline MPV.Results: The mean age of cases was 55.56±12.19 years. Males (66.67%) were outnumbering females (33.33%) in cases and controls showing male to female ratio of 2:1. Mean MPV was 10.2±1.27fl in cases and 7.26±0.79fl in controls which was statistically significant. Correlation of MPV with cardiogenic shock, arrhythmia and mortality was significant. Correlation of MPV with risk factor shows that diabetes was the only risk factor significant in AMI. Multiple logistic regression of risk factors with mortality in AMI shows that high MPV and obesity was found to be independently associated with mortality in AMI.Conclusions: Mean platelet volume is simple, easily available and cheap method. Serial estimation of MPV is a predictor of adverse clinical outcome in AMI so treating doctor can be more vigilant

Estudios efectivos de potencial para algunas nuevas moléculas híbridas para su actividad contra el cáncer de próstata

Objective: The present work aimed at developing novel hybrid molecules for targeting the prostate cancer. It is observed that two human shock proteins Hsp70 and Hsp90 are over-expressed in prostate cancer making them one of the important drug targets. We have designed and developed twelve new hybrid molecules 6a-j for targeting these proteins. Methods: The designed molecules were prepared following a four step reaction protocol and characterized on the basis of proton NMR and Mass spectrometry. These were subjected to in vitro studies by means of Oncotest and CCK-8 assays with two cell lines DU145 and 22Rv1. The selected molecules 6b and 6i were subjected to molecular docking and then for SPR based affinity assay. Results: Compounds 6b and 6i were found to be highly active anticancer compounds comparable to standard drug enzalutamide. They have significant IC50 and high dock score for the Hsp70 and Hsp90. These compounds are selective and have good binding affinity for the Hsp70 due to high Kd. Conclusion: Compound 6b and 6i can serve as lead molecules for the development of antiprostate cancer drugs with Hsp70 as target.Objetivo: El presente trabajo tuvo como objetivo desarrollar nuevas moléculas híbridas para atacar el cáncer de próstata. Se observa que dos proteínas de choque humano, Hsp70 y Hsp90, se sobreexpresan en el cáncer de próstata, lo que las convierte en uno de los objetivos farmacológicos importantes. Hemos diseñado y desarrollado doce nuevas moléculas híbridas 6a-j para dirigir estas proteínas. Métodos: Las moléculas diseñadas se prepararon siguiendo un protocolo de reacción de cuatro etapas y se caracterizaron sobre la base de RMN de protón y espectrometría de masas. Estos se sometieron a estudios in vitro por medio de ensayos Oncotest y CCK-8 con dos líneas celulares DU145 y 22Rv1. Las moléculas seleccionadas 6b y 6i se sometieron a acoplamiento molecular y luego a ensayo de afinidad basado en SPR. Resultados: Se descubrió que los Compuestos 6b y 6i son compuestos anticancerígenos muy activos comparables al fármaco estándar enzalutamida. Tienen un IC50 significativo y una puntuación alta para el muelle de Hsp70 y Hsp90. Estos compuestos son selectivos y tienen una buena afinidad de unión por la Hsp70 debido a la alta Kd. Conclusión: Los compuestos 6b y 6i pueden servir como moléculas principales para el desarrollo de fármacos antiprostáticos contra el cáncer con Hsp70 como objetivo

Estudios efectivos de potencial para algunas nuevas moléculas híbridas para su actividad contra el cáncer de próstata

Objective: The present work aimed at developing novel hybrid molecules for targeting the prostate cancer. It is observed that two human shock proteins Hsp70 and Hsp90 are over-expressed in prostate cancer making them one of the important drug targets. We have designed and developed twelve new hybrid molecules 6a-j for targeting these proteins. Methods: The designed molecules were prepared following a four step reaction protocol and characterized on the basis of proton NMR and Mass spectrometry. These were subjected to in vitro studies by means of Oncotest and CCK-8 assays with two cell lines DU145 and 22Rv1. The selected molecules 6b and 6i were subjected to molecular docking and then for SPR based affinity assay. Results: Compounds 6b and 6i were found to be highly active anticancer compounds comparable to standard drug enzalutamide. They have significant IC50 and high dock score for the Hsp70 and Hsp90. These compounds are selective and have good binding affinity for the Hsp70 due to high Kd. Conclusion: Compound 6b and 6i can serve as lead molecules for the development of antiprostate cancer drugs with Hsp70 as target.Objetivo: El presente trabajo tuvo como objetivo desarrollar nuevas moléculas híbridas para atacar el cáncer de próstata. Se observa que dos proteínas de choque humano, Hsp70 y Hsp90, se sobreexpresan en el cáncer de próstata, lo que las convierte en uno de los objetivos farmacológicos importantes. Hemos diseñado y desarrollado doce nuevas moléculas híbridas 6a-j para dirigir estas proteínas. Métodos: Las moléculas diseñadas se prepararon siguiendo un protocolo de reacción de cuatro etapas y se caracterizaron sobre la base de RMN de protón y espectrometría de masas. Estos se sometieron a estudios in vitro por medio de ensayos Oncotest y CCK-8 con dos líneas celulares DU145 y 22Rv1. Las moléculas seleccionadas 6b y 6i se sometieron a acoplamiento molecular y luego a ensayo de afinidad basado en SPR. Resultados: Se descubrió que los Compuestos 6b y 6i son compuestos anticancerígenos muy activos comparables al fármaco estándar enzalutamida. Tienen un IC50 significativo y una puntuación alta para el muelle de Hsp70 y Hsp90. Estos compuestos son selectivos y tienen una buena afinidad de unión por la Hsp70 debido a la alta Kd. Conclusión: Los compuestos 6b y 6i pueden servir como moléculas principales para el desarrollo de fármacos antiprostáticos contra el cáncer con Hsp70 como objetivo

Machine Learning Algorithm for Early Detection and Analysis of Brain Tumors Using MRI Images

Among the human body's organs, the brain is the most delicate and specialized. It is proven that after the heart stops then also brain death occurs within 3 to 5 minutes of death or within 3 to 5 minutes of loss of oxygen supply. A brain tumor is a life-threatening disease that can be detected at any age from an infant to an old person. Though a lot of people did research in the detection and analysis of a tumor, but then also detecting tumors at the early phase is still a much more arduous field in the biomedical study. This paper focuses on the comparative study of various existing algorithms in this field. This paper addresses the challenges and some issues in MRI brain tumor detection which are also addressed in this research

An open-label, multicenter, randomized, parallel, single-dose, comparative bioavailability study of two triamcinolone hexacetonide injectable suspensions in patients with knee osteoarthritis

Background: Triamcinolone hexacetonide (THA), a synthetic glucocorticoid with low solubility, can provide sustained pain relief and less systemic side effects in patients with knee osteoarthritis. This study aimed to characterize pharmacokinetic profile of THA-test product containing 20 mg/ml injectable suspension and compare its bioavailability with the standard reference in Indian patients with knee osteoarthritis. Methods: In this open-label, randomized, multicenter study, 44 adult patients were randomized (1:1; test n=23, reference n=21) to receive a single dose of test or reference products. The primary objective was to characterize the pharmacokinetic profile and compare bioavailability of both products via serum triamcinolone acetonide (TCA) concentration. Secondary objectives included safety and tolerability evaluation, impact on hypothalamic-pituitary-adrenal axis, and efficacy of test and reference products in reducing index knee pain. Results: Both products were absorbed with a median Tmax of 23.9 hours. Comparative bioavailability analysis demonstrated no statistically significant formulation effect for ln-transformed Cmax (1098.052 pg/ml for test, 1333.850 pg/ml for reference) and AUC0-t (159112.561 pg×h/ml for test, 211531.035 pg×h/ml for reference) for TCA. T/R ratio for Cmax was 82.3% and T/R ratio for AUC0-t was 75.2%, with >100% inter-subject variability for both Cmax and AUC0-t. Additionally, recovery time of cortisol levels of test and reference arms was 96 hours and 456 hours, respectively. Both products significantly reduced knee pain (p<0.0001). Conclusions: The test product provided lower systemic exposure and faster recovery of serum cortisol levels than the reference, while still providing similar beneficial effect in sustained index knee pain reduction

On Improving Pseudo-Relevance Feedback Using Pseudo-Irrelevant Documents

Pseudo-Relevance Feedback (PRF) assumes that the top-ranking n documents of the initial retrieval are relevant and extracts expansion terms from them. In this work, we introduce the notion of pseudo-irrelevant documents, i.e. high-scoring documents outside a top n that, are highly unlikely to be relevant. We show how pseudo-irrelevant documents can be used to extract; better expansion terms from the top-ranking n documents: good expansion terms are those which discriminate the top-ranking n documents from the pseudo-irrelevant documents. Our approach gives substantial improvements in retrieval performance over Model-based Feedback on several test collections

Economics of ginger (Zingiber officinale Rose.) production in Amravati District (Maharashtra, India)

The economics of production of ginger (Zingiber officinale) in Anjangaon Surji Taluka of Amravati District (Maharashtra, India) was studied during 1995-96. The study indicated that cost of cultivation and gross returns were positively related with size of the holding. The overall cost of cultivation was Rs. 1,32,415.63 per ha and Rs. 1012.04 per qtl. The overall net returns at cost C (which included all costs) was Rs. 50,399.23 per ha. However, net returns decreased with.size of holdings. The overall input-output ratio at cost C was 1.38. &nbsp

An Empirical Analysis of the Relationship between Land Size, Ownership, and Soybean Productivity - New Evidence from the Semi-Arid Tropical Region in Madhya Pradesh, India

The intervention of the International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) at the benchmark site in Madhya Pradesh, India is part of a larger project – “Improving Management of Natural Resources for Sustainable Rainfed Agriculture” funded by the Asian Development Bank (ADB). The main aim of the project is to increase the productivity and sustainability of the medium and high water-holding capacity soils in the intermediate rainfall ecoregions in India, Vietnam, and Thailand. This study examines the relationship between land size and various variables including the soybean productivity relationship among owner-operated and share cropper-operated farms. Primary data was collected using an interview schedule from the villages of Jaoti, Kundhankhedi, Kherkhedi, and Lalatora in Vidisha district, Madhya Pradesh for the 1999 rainy season crop. The productivity of evaluated owner-operated farms is marginally higher at 0.72 t ha-1 compared to 0.68 t ha-1 in case of share cropped farms. The productivity of evaluated trial farms in Lalatora micro-watershed which is used as a demonstration micro-watershed for evaluating improved management practice has been higher at 1.1 t ha-1. The inverse-relationship between land size and productivity is found for both owner-operated (r = 0.27) and share cropper-operated farms (r = 0.30). The average profit is higher among owner-operated farms at Rs. 2045 ha-1 compared to Rs. 1773 ha-1 among share cropped farms. The profitability for the landlords and share croppers is documented and evidence is presented on the exploitative nature of the emerging 20:80 crop sharing contract. The low productivity has been due to waterlogging which occurred due to heavy rains during the sowing period