Thoorvai novel from the point of view of religious anthropology

The role of the novel in modern Tamil literature is so great that it is possible to convey through the novel a lot of information which neither poetry nor a short story can speak of, because it is possible to write extensively in the form of a novel. Although the novel is valued as a gift of the shoe era, it can be regarded as doing a great job of recording the dynamics of Tamil society. From individual intelligence to society, caste, region, local history, the history of the struggle of the trade unions, the history of the Indian freedom struggle, the life records of the department, urbanization and the economic crises that result from it, etc., have been recorded. In this article, Dharman's novel Thoorvai is examined from the point of view of religious anthropology

Cho. Dharman's Sool novel from the point of view of social anthropology

As a result of the development of the human mind, there are many forms of literature that have emerged. These reflect the change in the development of language from time to time. The novel is one of these forms of reflection. All the anthropological aspects of people's lives are expressed in the novels. In order to learn about the people, there are more sociological elements of novel literature that record the folk life than the classical literature. On that basis, after Ki.Ra. & Poomani, the life philosophies of the people of karisal region, and the novel 'Sool', which records a great deal in terms of the devendrakula Vellalar race known as Pallar, examines and explains the sociocultural and anthropological aspects recorded in them

Segundo Congreso Salesiano de Ciencia, Tecnología e Innovación para la Sociedad

La segunda edición del Congreso Salesiano de Ciencia, Tecnología e Innovación para la Sociedad, CITIS, realizado el 2 y 3 de diciembre de 2015 y organizado por la Universidad Politécnica Salesiana (sede Guayaquil), ofreció un espacio idóneo para la presentación, difusión e intercambio de importantes investigaciones (nacionales e internacionales) a los docentes investigadores y a la comunidad universitaria en general. Los trabajos recogidos en estas Memorias Académicas pertenecen a diferentes líneas de investigación del área de la Ingeniería: Telecomunicaciones, Automatización y Control, Procesos Industriales, Sistemas Eléctricos de Potencia, Telemática e Informática Aplicada, áreas de interés en esta segunda edición del CITIS. Cabe destacar que se evidencia la preocupación por la dimensión humana y social mediante el desarrollo responsable de la ciencia y la tecnología. La realización de este Congreso ha puesto en evidencia la importancia y pertinencia de la actividad investigativa que se genera en las universidades (en proyectos desarrollados por los docentes investigadores e, incluso, por los estudiantes de grado y posgrado), así como los altos niveles de compromiso académico y social

Carbon Farming: A Promising Approach to Climate Mitigation and Adaptation in India

This article addresses India's role in the reduction of GHG emissions, the impact of renewable energy and the application of solar energy. In response to the climatic challenges, India is meticulously stepping towards offsetting or the onset of carbon farming such as organic cultivation and solar energy interventions. Offset carbon farming area of 5. 387 Mha organic farming could sequester carbon annually of 6.567 mt, simultaneously; it has the advantage of reducing synthetic nitrogen fertilizer application doses ranging from a minimum of 0.27 mt and a maximum of 1.08 mt per hectare. Furthermore, solar energy can indirectly be used as SWH suitable for average family households contributing carbon credits of 771 kg-824 kg in addition to saving an annual electricity burden of around 1365 kWh to 1459 kWh and directly utilized for solar PV electricity generation of 1 MW will offset approximately 730 tons of CO2 emissions, which is equivalent to 33, 183 carbon-absorbing trees (22 kg of CO2 absorbed/ tree/year). Carbon farming has challenges encompassing economic, technological, policy, and knowledge-based barriers that require innovative solutions and concerted stakeholder efforts

An unusual clinical presentation of gingival melanoacanthoma

Gingival melanoacanthoma is a rare, benign pigmented lesion characterized clinically by sudden onset and rapid growth of a macular brown black lesion and histologically by acanthosis of superficial epithelium and proliferation of dendritic melanocytes. This article reports a previously undescribed case of pigmented unilateral diffuse gingival enlargement, which on histopathological examination proved to be melanoacanthoma. Intraoral examination revealed pigmented unilateral diffuse gingival enlargement in relation to second and third quadrants buccally, palatally/lingually. Based on these clinical findings, gingivectomy was performed and the excised tissue was sent for biopsy. Microscopic examination revealed acanthotic and parakeratotic surface epithelium with dendritic melanocytes distributed in basal and suprabasal layers of the epithelium. 1 year follow-up recall revealed no recurrence of lesion at the surgical sites. Our patient exhibits an unusual clinical presentation of melanoacanthoma of gingiva. Pigmented gingival overgrowth of recent origin and without any etiologic factors warrants histopathologic examination

ASSESS THE KNOWLEDGE AND ATTITUDE ON PREVENTION OF DENGUE AMONG THE PATIENTS ATTENDANTS

Objectives: Dengue infection is increasingly recognized as one of the worlds emerging infection disease. Lack of knowledge and unfavourable attitude regarding preventive measure of dengue among public is leading to outbreak of dengue in many parts of India. The aim of the study was to assess the level of knowledge and attitude on prevention of dengue among the patients attendants in Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry. Settings and Design: Descriptive cross-sectional study design. The study setting was Medical Record Department, JIPMER where patients came for the registration for the purpose of seeking treatment. Methods: The sample size was 176. The sampling technique used for the study was consecutive sampling who were satisfied with inclusion technique. The data collected with the help of questionnaire by face to face interview method. Statistical analysis used: All the categorical data were presented on frequencies, percentages, mean standard deviation, chi-square and correlation coefficient used to find the correlation of knowledge and attitude on dengue fever. Results: The study finding reported that 117(66.5%) of the participants had moderately adequate knowledge and 93 (52.8) moderately favorable attitude on prevention of dengue fever, at the same time adequate knowledge and most favorable attitude was not satisfactory level. Conclusions: It shows that public needs more educational intervention to improve their health practice against dengue by the health care provider

The calcium ATPase SERCA2 regulates desmoplakin dynamics and intercellular adhesive strength through modulation of PKCα signaling

Darier's disease (DD) is an inherited autosomal-dominant skin disorder characterized histologically by loss of adhesion between keratinocytes. DD is typically caused by mutations in sarcoendoplasmic reticulum Ca2+-ATPase isoform 2 (SERCA2), a major regulator of intracellular Ca2+ homeostasis in the skin. However, a defined role for SERCA2 in regulating intercellular adhesion remains poorly understood. We found that diminution of SERCA2 function by pharmacological inhibition or siRNA silencing in multiple human epidermal-derived cell lines was sufficient to disrupt desmosome assembly and weaken intercellular adhesive strength. Specifically, SERCA2-deficient cells exhibited up to a 60% reduction in border translocation of desmoplakin (DP), the desmosomal cytolinker protein necessary for intermediate filament (IF) anchorage to sites of robust cell-cell adhesion. In addition, loss of SERCA2 impaired the membrane translocation of protein kinase C α (PKCα), a known regulator of DP-IF association and desmosome assembly, to the plasma membrane by up to 70%. Exogenous activation of PKCα in SERCA2-deficient cells was sufficient to rescue the defective DP localization, desmosome assembly, and intercellular adhesive strength to levels comparable to controls. Our findings indicate that SERCA2-deficiency is sufficient to impede desmosome assembly and weaken intercellular adhesive strength via a PKCα-dependent mechanism, implicating SERCA2 as a novel regulator of PKCα signaling.—Hobbs, R. P., Amargo, E. V., Somasundaram, A., Simpson, C. L., Prakriya, M., Denning, M. F., Green, K. J. The calcium ATPase SERCA2 regulates desmoplakin dynamics and intercellular adhesive strength through modulation of PKCα signaling

Treosulfan Exposure Predicts Thalassemia-free Survival In Patients With Beta Thalassemia Major (TM) Undergoing Allogeneic Hematopoietic Cell Transplantation

A toxicity-reduced conditioning regimen with Treosulfan, Fludarabine, and Thiotepa in patients with high-risk β- thalassemia major has significantly improved HCT outcomes. However, complications resulting from regimen-related toxicities (RRTs), mixed chimerism, and graft rejection remain a challenge. We evaluated the dose-exposure-response relationship of Treosulfan and its active metabolite S, S-EBDM, in a uniform cohort of patients with β-thalassemia major to identify whether therapeutic drug monitoring (TDM) and dose adjustment of Treosulfan is feasible. Plasma Treosulfan/S, S-EBDM levels were measured in seventy-seven patients using a validated LC-MS/MS method, and the PK parameters were estimated using nlmixr2. The influence of Treosulfan & S, S-EBDM exposure, and GSTA1/NQO1 polymorphisms on graft rejection, RRTs, chimerism status, and 1-year Overall Survival (OS), and Thalassemia Free Survival (TFS) were assessed. We observed that Treosulfan exposure was lower in patients with graft rejection than those without (1655 vs. 2037 mg*h/L, p=0.07). Pharmacodynamic modeling analysis to identify therapeutic cut-off revealed that Treosulfan exposure ≥1660 mg*hr/L was significantly associated with better 1-year TFS (97% vs. 81%, p=0.02) and a trend to better 1-year OS (90% vs. 69%, p=0.07). Further, multivariate analysis adjusting for known PreHCT risk factors also revealed Treosulfan exposure <1660mg*h/L (HR=3.23; 95% CI=1.12-9.34; p=0.03) and GSTA1*B variant genotype (HR=3.75; 95% CI=1.04-13.47; p=0.04) to be independent predictors for inferior 1-year TFS. We conclude that lower Treosulfan exposure increases the risk of graft rejection and early transplant-related mortality affecting TFS. As no RRTs were observed with increasing Treosulfan exposure, TDM-based dose adjustment could be feasible and beneficial