106 research outputs found
Olfactory Neuroblastomas: An Experience of 24 Years
Objective. The aim of this study was to evaluate clinicopathological findings and the efficacy of the treatment modalities used in patients with olfactory neuroblastomas. Study Design. Retrospective record review. Setting. Istanbul University, Cerrahpasa Medical Faculty, medical oncology outpatient clinic. Subjects and Methods. There were 3 stage A tumors, 5 stage B and 11 stage C according to the Kadish staging system. There were 5 grade I/II and 12 grade III/IV according to the Hyams' histopathologic system. Involvement to orbita was detected in eight patients at the time of diagnosis. Results. The median follow-up period was 23.7 months. The 5-year survival rate for the whole group was 26%. The stage A/B groups exhibited a better survival rate than the C group with 2-year survival rates being 25 versus 71% respectively (P = .008). The grade I/II groups exhibited a better survival rate than the grade III/IV groups with 2-year survival rates being 50 versus 16% respectively (P = .001). The group who had orbital involvement exhibited a poor survival rate than the group of patients who had no involvement of the orbital. Conclusion. In our study, tumor stage, histopathologic grading, involvement of the orbita, brain and bone marow metastases were the statistically significant prognostic factors
Treatment of ankylosing spondylitis
Ankylosing spondylitis is a chronic, inflammatory, rheumatic disease
that can reduce the quality of life and increase the risk of disability
and mortality. It also causes direct and indirect economic losses due to
health expenses and as a result of workforce loss. Management of this
disease consists of pharmacological and nonpharmacological modalities.
Until recently, pharmacological treatment options have been very
limited. However, development of novel biological drugs revolutionized
the management of this disease. The aim of this review article is to
present an updated overview of the pharmacologic treatment of ankylosing
spondylitis. Nonpharmacological treatment modalities including
physiotherapy and exercise are only briefly mentioned and surgical
treatment is not discussed
Documentation of Slow Coronary Flow by the Thrombolysis in Myocardial Infarction Frame Count (TIMI) in Patients with Poor Glycemic Control with Angiographically Normal Coronary Arteries
Conclusion TIMI frame count is increased in patients with poor glycemic control. These values might be improved with therapy
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