Σύνθεση , χαρακτηρισμός και μελέτη νέων σύμπλοκων ενώσεων του αντιμονίου (III) με θειοαμίδια με πιθανή βιολογική δράση

Thirty-one new antimony(III) complexes with the heterocyclic thiones 2-mercapto-1- methylimidazole (C4H6N2S) 2-mercaptothiazolidine (C3H5NS2), 2-mercaptobenzimidazole (C7H6N2S), 2-mercapto-5-methylbenzimidazole (C8H8N2S), 5-ethoxy-2- mercaptobenzimidazole (C9H10N2OS), 3-methyl-2-benzothiazolinthion (C8H7NS2), 2- mercaptopyridine (C5H5NS), 2-mercaptopyrimidine (C4H4N2S), 2-mercapto-3,4,5,6- tetrahydro-pyrimidine (C4H8N2S) of formulae {[SbCl3(TU)2].H2O}, {[SbCl3(MMI)2].H2O}, {[SbCl2(MBZIM)4]+.Cl-.2H2O.(CH3OH)}, {[SbCl2(MBZIM)4]+.Cl-.2H2O.(CH3OH)}, [SbCl3(MBZIM)2], [SbCl3(MMBZIM)2.CH2Cl2], [SbCl3(EtMBZIM)2], [SbCl3(MTZD)2], [SbCl3(MMBZT)2], [SbCl3(tHPMD)2], [SbCl3(PYT)2], [SbCl3(PMT)2], [SbBr3(TU)2], [SbBr3(MMI)2], {[SbBr2(MBZIM)4]+.Br-.2H2O.(CH3OH)}, [SbBr3(MMBZIM)2], [SbBr3(EtMBZIM)2.MeOH], [SbBr3(MTZD)2], [SbBr3(MMBZT)2], [SbBr3(tHPMD)2], [SbBr3(PYT)2], [SbBr3(PMT)2], {[SbI3(MMI)2].MeOH}, [SbI3(MBZIM)2], {[SbI3(MMBZIM)3].MeOH}, [SbI3(EtMBZIM)2.H2O], {[SbI3(MTZD)]}, {[Sb2I6(MMBZT)3]}, {[SbI3(tHPMD)3].MeOH}, {[SbI3(PYT)]}, {[SbI3(PMT)2]} have been synthesized and characterized by elemental analysis, FTIR spectroscopy, FT-Raman spectroscopy, TG-DTA analysis, X-ray powder diffraction, UV spectroscopy, ESI-MS spectroscopy, 1H and 13C NMR spectroscopy, conductivity measurements. The crystal structures of {[SbCl2(MBZIM)4]+.Cl-.2H2O.(CH3OH)}, {[SbCl2(MBZIM)4]+.Cl- .2H2O.(CH3OH)}, [SbCl3(MBZIM)2], [SbCl3(EtMBZIM)2], [SbCl3(MTZD)2], [SbCl3(tHPMD)2], {[SbBr2(MBZIM)4]+.Br-.2H2O.(CH3OH)}, [SbBr3(MMBZIM)2], [SbBr3(EtMBZIM)2.MeOH], [SbBr3(MTZD)2], [SbBr3(MMBZT)2], [SbBr3(tHPMD)2], [SbBr3(PYT)2], {[SbBr5]2-[(PMTH2 +)2]}, [SbI3(EtMBZIM)2.H2O], {[SbI3(MTZD)]}, {[Sb2I6(MMBZT)3]}, {[SbI3(tHPMD)3].MeOH}, {[SbI3(PYT)]} were also determined by Xray diffraction analysis.Στην διατριβή αυτή περιγράφονται τριάντα μια νέες σύμπλοκες ενώσεις του Αντιμονίου (ΙΙΙ) με τις ετεροκυκλικές θειόνες 2-mercapto-1-methylimidazole (C4H6N2S) 2- mercaptothiazolidine (C3H5NS2), 2-mercaptobenzimidazole (C7H6N2S), 2-mercapto-5- methylbenzimidazole (C8H8N2S), 5-ethoxy-2-mercaptobenzimidazole (C9H10N2OS), 3- methyl-2-benzothiazolinthion (C8H7NS2), 2-mercaptopyridine (C5H5NS), 2- mercaptopyrimidine (C4H4N2S), 2-mercapto-3,4,5,6-tetrahydro-pyrimidine (C4H8N2S) και μοριακό τύπο {[SbCl3(TU)2].H2O}, {[SbCl3(MMI)2].H2O}, {[SbCl2(MBZIM)4]+.Cl- .2H2O.(CH3OH)}, {[SbCl2(MBZIM)4]+.Cl-.2H2O.(CH3OH)}, [SbCl3(MBZIM)2], [SbCl3(MMBZIM)2.CH2Cl2], [SbCl3(EtMBZIM)2], [SbCl3(MTZD)2], [SbCl3(MMBZT)2], [SbCl3(tHPMD)2], [SbCl3(PYT)2], [SbCl3(PMT)2], [SbBr3(TU)2], [SbBr3(MMI)2], {[SbBr2(MBZIM)4]+.Br-.2H2O.(CH3OH)}, [SbBr3(MMBZIM)2], [SbBr3(EtMBZIM)2.MeOH], [SbBr3(MTZD)2], [SbBr3(MMBZT)2], [SbBr3(tHPMD)2], [SbBr3(PYT)2], [SbBr3(PMT)2], {[SbI3(MMI)2].MeOH}, [SbI3(MBZIM)2], {[SbI3(MMBZIM)3].MeOH}, [SbI3(EtMBZIM)2.H2O], {[SbI3(MTZD)]}, {[Sb2I6(MMBZT)3]}, {[SbI3(tHPMD)3].MeOH}, {[SbI3(PYT)]}, {[SbI3(PMT)2]}. Οι ενώσεις έχουν χαρακτηριστεί με στοιχειακή ανάλυση, φασματοσκοπία FT-IR, FT-Raman, ανάλυση TG-DTA, ακτίνες-Χ κώνεος, φασματοσκοπία UV-Vis, ESI-MS, 1H και 13C NMR και με αγωγημομετρικές τιτλοδοτήσεις. Επίσης υπολογίστηκαν οι μοριακές και κρυσταλλικές δομές των ενώσεων {[SbCl2(MBZIM)4]+.Cl-.2H2O.(CH3OH)}, {[SbCl2(MBZIM)4]+.Cl- .2H2O.(CH3OH)}, [SbCl3(MBZIM)2], [SbCl3(EtMBZIM)2], [SbCl3(MTZD)2], [SbCl3(tHPMD)2], {[SbBr2(MBZIM)4]+.Br-.2H2O.(CH3OH)}, [SbBr3(MMBZIM)2], [SbBr3(EtMBZIM)2.MeOH], [SbBr3(MTZD)2], [SbBr3(MMBZT)2], [SbBr3(tHPMD)2], Ph.D Thesis Ibrahim Ismet Ozturk VII [SbBr3(PYT)2], {[SbBr5]2-[(PMTH2 +)2]}, [SbI3(EtMBZIM)2.H2O], {[SbI3(MTZD)]}, {[Sb2I6(MMBZT)3]}, {[SbI3(tHPMD)3].MeOH}, {[SbI3(PYT)]} με ανάλυση περίθλασης ακτίνων-Χ. Στα σύμπλοκα {[SbCl2(MBZIM)4]+.Cl-.2H2O.(CH3OH)}, {[SbCl2(MBZIM)4]+.Cl- .2H2O.(CH3OH)} και {[SbBr2(MBZIM)4]+.Br-.2H2O.(CH3OH)}, τέσσερα άτομα θείου από τις θειόνες και δύο άτομα αλογόνου σχηματίζουν ένα κατιονικό σωματίδιο [SbS4X2]+ με οκταεδρική γεωμετρία (Oh) στο οποίο δύο άτομα αλογόνου βρίσκονται στις αξονικές θέσεις.. Ένα ανιόν αλογόνου αντισταθμίζει το φορτίο του κατιόντος. Στο σύμπλοκο {[SbI3(tHPMT)3].MeOH}, τρία άτομα θείου από τις θειόνες και τρία άτομα ιωδίου σχηματίζουν ένα ουδέτερο σύμπλοκο με οκταεδρική γεωμετρία Oh με δύο άτομα ιωδίου σε αξονικές θέσεις ενώ τρία άτομα θείου και ένα ιωδίου καταλαμβάνουν τις ισημερινές και meridional διαμόρφωση. Το σύμπλοκο [SbBr3(MMBZT)2] είναι μονομερές

BURDEN OF CARE AND QUALITY OF LIFE IN RELATIVES OF OPIOID DEPENDENT MALE SUBJECTS

Background: The aim of this study was to compare the quality of life (QoL) and family burden in relatives of patients with heroin dependence with that of healthy controls. Subjects and methods: A total of 50 heroin dependent patients and 50 of their relatives and 50 healthy subjects and 50 of their relatives were included in the study. The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders (SCID-I) was used to determine the heroin dependence and other Axis I psychiatric disorders. Family burden and QoL levels in the relatives were assessed with the Zarit Burden Interview (ZBI) protocol and the World Health Organization Quality of Life Assessment-Brief (WHOQOL-BREF), respectively. Results: There were no significant differences in demographic characteristics between the groups. When compared with healthy controls, family members of heroin dependence patients had significantly higher ZBI scores and significantly lower all subscale scores of the WHOQOL-BREF. ZBI score was positively correlated with duration of the illness. All WHOQOL-BREF subscale scores were negatively correlated with duration of the illness. Conclusions: The study suggests that heroin dependence not only affects the lives of patients but also the lives of their family members. Heroin dependence leads to high burden on the family and also impairs the QoL of relatives