Topological contribution to magnetism in the Kane-Mele model: An explicit wave function approach

In our previous publication [S. Ozaki and M. Ogata, Phys. Rev. Research 3, 013058], the quantization of the orbital-Zeeman (OZ) cross term in the magnetic susceptibility, or the cross term of spin Zeeman and orbital effect, was shown for the Kane-Mele model using the expansion around the Dirac points. In the present study, we accurately evaluate the orbital, spin-Zeeman, and OZ cross term of the Kane-Mele model using a recently developed formulation. This formula is written in terms of the explicit Bloch wave functions, and enables us to evaluate each contribution taking account of the integration over the whole Brillouin zone and the summation over all the bands. As a result, additional contributions such as core-electron diamagnetism are found. Furthermore, our evaluation confirms the quantization of the OZ cross term and reveals its behavior including the metallic case. The possibility of experimental detection of the quantization is discussed

Evaluation of the region 1 field-aligned current from the low-latitude boundary layer using the 1989 Tsyganenko model

On the basis of the 1989 Tsyganenko magnetic field model, the field-aligned current (FAC) density distribution in the low-latitude boundary layer (LLBL) is numerically evaluated by assuming the entry of magnetosheath particles into the LLBL. The calculated FAC density/intensity profiles are consistent with observations. This FAC generation arises from the divergence of the magnetic drift current density carried by LLBL particles, and the current intensity is then increased with their kinetic energy density. The FAC generation occurs at the inner edge of the LLBL whenever sheath particles penetrate into the magnetosphere, regardless of the entry process. It is also emphasized that the LLBL FAC production is an inevitable consequence of the formation of the magnetopause, because the magnetopause currents act to shield the magnetic field originating from the currents inside the closed region of the magnetosphere, causing the LLBL inner edge to intersect the magnetic drift paths. This simple situation can be illustrated by calculating the distribution of the flux tube volume in the Tsyganenko model

Distortion of the nightside boundary of the "firmly-closed" region in the 1996 Tsyganenko magnetic field model

This paper proposes that the outer boundary of the "firmly-closed" region should be represented by field lines with the adiabaticity parameter, K, equal to unity at the equator, where K^2 is the ratio between the radius of the field-line curvature and the Larmor radius of an ion with 1 keV of energy. Just outside the boundary where K = 1, plasma particles (primarily ions) can be nonadiabatically accelerated in the presence of the dawn-to-dusk electric field. An inwardly convecting flux tube will attain the maximum content of nonadiabatically accelerated particles when it passes the K - 1 boundary. Thus, the K = 1 boundary outlines the region of the plasma population with a maximum content of nonadiabatically accelerated particles. In addition, the field lines with K = 1 are shown to have a minimum field strength of roughly 1 nT at the equator. From this fact, a field line with k < 1 may not be considered as being "firmly-closed" in the sense that such a field line may easily merge with an interplanetary field line. The outer boundary of the nightside firmly-closed region in the Tsyganenko model has an IMF Bz dependence that is consistent with observations. Moreover, this boundary is found to be "distorted", favoring the generation of region 1 field-aligned currents

Latitudinal structure of the nightside region 1 field-aligned current observed from the EXOS-D satellite

The average pattern of region 1 field-aligned current (FAC) of IIJIMA and POTEMRA (J. Geophys. Res., 81, 2165, 1976a; J. Geophys. Res., 83, 599, 1978) spans 2-3° in magnetic latitude. Using the magnetic field data acquired with the EXOS-D satellite, we notice that sharp variations of magnetic field perturbation, showing the high current densities of several micro-amperes per squared meter at the ionospheric height, are included in the region 1 current zone. In this paper, we focus our analysis on a sharp gradient of magnetic field change within 1° in latitude. In the 20-04 MLT sector, the thin current sheet as an important part of the region 1 FAC system is often found to be just equatorward of the boundary FAC system (FuKUNism et al, J. Geophys. Res., 98, 11235, 1993). A statistical survey of more than 200 satellite\u27s crossings of the region 1 zone (in the 17-05 MLT range) shows that about 60% of the identified region 1 current systems have the latitudinal structure of a thin (on average, 0.5°) current sheet with current intensity greater than one third of the total FAC intensity of the region 1 system

Distortion of the outer boundary of the closed region in the Tsyganenko magnetic field model

Using the Tsyganenko magnetic field model (TSYGANENKO, Planet. Space Sci., 37, 5, 1989) we make an attempt to determine the outer boundary of the closed region when the interplanetary magnetic field (IMF) is southward. As a simple magnetic field model including the effect of IMF B_z<0, the B_z component of a constant value of minus a few nanoTeslas is added to the magnetic field in the Tsyganenko model with low K_p values. In this paper, if the magnetic field strength, B, is not less than 2 nT in the whole range of a field line (namely the minimum B along a field line is greater than 2 nT), this field line is judged to be "firmly" closed. The firmly closed field lines are thought to be definitely closed as long as the fluctuation amplitude of B_z (around its average level) in the interplanetary (solar wind) magnetic field is less than 2 nT. The outer boundary of the firmly closed region is then constituted by field lines with the minimum B of 2 nT. This boundary is found to be close to (just inside of) the open-closed boundary, which can be determined with accuracy of 0.01° in latitude of the foot point of a field line. It is found that a circle with the center at a latitude of about 85° on the midnight meridian can be fitted to the outer boundary of the firmly closed region, as it is projected to the ionosphere. Interestingly this circle coincides with a typical auroral circle; the auroral circles are those delineating the poleward boundary of the quiet auroral belt, which were earlier identified from the statistical analysis of satellites\u27 auroral images by MENG et al. (J. Geophys. Res., 82, 164, 1977). Importantly we find that the outer boundary of the firmly closed region is "distorted" on the nightside in the sense that the ionospheric projection of the average magnetic drift velocity of a plasma with isotropic pressure is not parallel to the boundary; more specifically, that of an isotropic ion fluid has an equatorward component on the duskside boundary and a poleward one on the dawnside boundary, respectively. This kind of the boundary distortion may be one of the possible causes of the generation of the nightside region 1 field-aligned current, which has been first suggested by HRUSKA (J. Geophys. Res., 91, 371, 1986) and recently, further studied by YAMAMOTO and INOUE (Proc. NIPR Symp. Upper Atmos. Phys., 11, 106, 1998)

The Effect of Insulin Administration and Antibacterial Irrigation with Chlorhexidine Gluconate on the Disturbance of Periodontal Tissue Caused by Food Impaction in Streptozotocin-Induced Diabetic Rats

福岡歯科大学2015年

Cyclophosphamide Promotes Arrested Development of the Dental Root in Mice

Cyclophosphamide (CPA) is a commonly used chemotherapeutic agent to treat cancer. Among its many side effects is the well-known consequence on tooth development when administered at early ages. This study elucidated the effects of CPA on development of the mandibular molar in mice. Mice received a single intraperitoneal injection of CPA at different doses and development times. CPA treatment led to weight loss and alopecia but had no effect on disturbances in tooth eruption or crown shape. However, at higher doses, there was arrested root development and early apical foramen closure histologically related to the formation of the cervical loop structure in the apical portion of the root. In cell culture experiments, the Hertwig\u27s epithelial root sheath cell line (HERS01a) was cultured with or without CPA. At high doses of CPA, HERS01a cells showed decreases in E-cadherin expression, while N-cadherin expression was upregulated, indicating that this cadherin switch may promote an epithelial-to-mesenchymal transition (EMT)-like phenomenon. These findings suggest that administration of high doses of CPA can lead to arrested root development of the molars and an EMT-like phenomenon.福岡歯科大学2019年

Recovery of Motor Function in Patients with Subaxial Cervical Spine Injury Relevant to the Fracture Pattern

In this study, we studied the relationship between fracture patterns and motor function recovery in 70 consecutive patients with cervical spinal cord injury. Fractures were categorized into 6 fracture types and subdivided into stages according to the Allen-Ferguson classification system:compressive flexion (CF), distractive flexion (DF), compressive extension (CE), distractive extension (DE), vertical compression (VC) and lateral flexion (LF). Paralysis was evaluated using the American Spinal Injury Association (ASIA) impairment scale at the time of injury and 3 months afterwards. The residual rate of complete motor palsy (ASIA grade A or B) at the final examination was higher in those patients with DE fractures than those with CF, DF or CE. The final outcomes were as follows. Of the 14 patients who were classified with CF fractures, residual palsy was frequently seen in patients who had stage 5 injury. Of the 27 patients with DF fractures, residual palsy occurred in about half of the patients who had stage 4 or 5 injury. Of the 18 patients with CE fractures, residual palsy occurred in half of the patients with stage 3 injury or higher. Finally, of the 7 patients with DE fractures, the rate of residual palsy was high even for the stage 1 and 2 cases;indeed, all DE patients who had complete motor palsy at the first examination had residual palsy at the final examination. Accordingly, we conclude that motor recovery may be related to fracture pattern

Osteogenic potential for replacing cells in rat cranial defects implanted with a DNA/protamine complex paste.

Osteoinductive scaffolds are required for bone tissue engineering. The aim of the present study was to assess the osteoinductive capacity of deoxyribonucleic acid (DNA)/protamine complexes in a rat model of critical-size calvarial defects. In addition, we investigated whether cultured mesenchymal-like cells (DP-cells) outgrown from DNA/protamine complex engrafted defects could differentiate to become osteogenic cells in vitro. DNA/protamine complexes were prepared by reactions between DNA and protamine sulfate solutions with stirring. Critical-sized (8mm) calvarial defects were created in the central parietal bones of adult rats. Defects were either left empty or treated with DNA/protamine complex scaffolds. Subsequently, micro-computed tomography (micro-CT), histological, and immunohistochemical analyses were performed. Micro-CT and histological assays showed that DNA/protamine complex engrafted defects had enhanced bone regeneration. DP-cells were expanded from explants of DNA/protamine complex engrafted defects using an explant outgrowth culture system. Osteogenesis-related factors were assessed in DP-cells after treatment with an osteoblast-inducing reagent (OIR). After 3months, nearly complete healing was observed for DNA/protamine complex engrafted calvarial defects. Increased alkaline phosphatase (ALP) activity and Alizarin red staining were found for cultured DP-cells. These cells had high expression levels of osteogenic genes, including those for RUNX-2, ALP, osteopontin, and osteocalcin. These results indicated that DNA/protamine complexes could facilitate bone regeneration in calvarial defects. Moreover, in vitro osteogenic induction experiments showed that DP-cells outgrown from DNA/protamine engrafted defects had an osteogenic potential. Based on these results, we suggest that DNA/protamine complexes may recruit osteocompetent cells in these defects, where they differentiate to osteogenic cells.福岡歯科大学2015年

MLH1-mediated recruitment of FAN1 to chromatin for the induction of apoptosis triggered by O6-methylguanine

O6 -Methylguanines (O6 -meG), which are produced in DNA by the action of alkylating agents, are mutagenic and cytotoxic, and induce apoptosis in a mismatch repair (MMR) protein-dependent manner. To understand the molecular mechanism of O6 -meG-induced apoptosis, we performed functional analyses of FANCD2 and FANCI-associated nuclease 1 (FAN1), which was identified as an interacting partner of MLH1. Immunoprecipitation analyses showed that FAN1 interacted with both MLH1 and MSH2 after treatment with N-methyl-N-nitrosourea (MNU), indicating the formation of a FAN1-MMR complex. In comparison with control cells, FAN1-knockdown cells were more resistant to MNU, and the appearances of a sub-G1 population and caspase-9 activation were suppressed. FAN1 formed nuclear foci in an MLH1-dependent manner after MNU treatment, and some were colocalized with both MLH1 foci and single-stranded DNA (ssDNA) created at damaged sites. Under the same condition, FANCD2 also formed nuclear foci, although it was dispensable for the formation of FAN1 foci and ssDNA. MNU-induced formation of ssDNA was dramatically suppressed in FAN1-knockdown cells. We therefore propose that FAN1 is loaded on chromatin through the interaction with MLH1 and produces ssDNA by its exonuclease activity, which contributes to the activation of the DNA damage response followed by the induction of apoptosis triggered by O6 -meG.福岡歯科大