ANALYSIS OF FISCAL DEFICIT SUSTAINABILITY IN NIGERIAN ECONOMY: AN ERROR CORRECTION APPROACH

ABSTRACT The study investigates the sustainability of fiscal policy in Nigeria over the period of 1980-201

Vitamin D3 Receptor Activation Rescued Corticostriatal Neural Activity and Improved Motor-Cognitive Function in −D2R Parkinsonian Mice Model

Background: fourth generation antipsychotics have been implicated in the blockade of calcium signalling through inhibition of dopamine receptive sites on dopaminergic D2 Receptor (D2R). As a result of the abnormal calcium signalling associated with D2R inhibition, changes occur in the motor and memory neural axis leading to the observed behavioural deficits after prolonged haloperidol. Thus, Vitamin D3 receptor (VD3R), a calcium controlling receptor in the striatum can be targeted to relief the neurological symptoms associated with haloperidol (−D2R) induced PD. Aim: This study sets to investigate the role of VD3R activation in vitro and in vivo after haloperidolinduced Dopaminergic (D2R) blockade. In addition, we examined the associated neural activity and behavioural changes in parkinsonian and VDRA intervention mice. Methods: Dopaminergic D2R inhibition was investigated in vitro using Melanocytes isolated from the scale of a Tilapia. In four separate set ups, the cells were cultured in calcium free Ringer’s solution as follows; 300 μM haloperidol, 100 μM VD3, 100 mM calcium chloride and a combination of 300 μM haloperidol and 100 μM VD3. Subsequently, dopaminergic vesicle accumulation and calcium signalling were observed in bright field microscopy using blue and green fluorescence probes. In the second phase, PD was induced in adult BALB/c mice (−D2; n = 8) after 14 days of intraperitoneal haloperidol treatment (10 mg/Kg). A set of n = 4 mice were untreated (−D2) while the other group (n = 4) received 100 mg/Kg of VD3 for 7 days (−D2/+VDR). The control groups (n = 4 each) were treated with normal saline (NS) and VD3 (+VDR) for 14 days. At the end of the treatment phase, the animals were assessed in Rotarod, parallel bar-, cylinder-, Y-Maze-, one trial place recognition- and novel object recognition-(NOR) tests. Neural activity was measured using chronic electrode implants placed in the M1 (motor cortex), CPu (striatum), CA1 (hippocampus) and PFC (prefrontal cortex). Neural activity was compared with the outcomes of behavioural tests for memory and motor functions and data was expressed as mean ± SEM (analysed using ANOVA with Tukey post-hoc test, significant level was set at 0.05). Results/Discussion: in vitro outcomes show that VDR increase calcium signalling and reverses the effect of haloperidol; specifically by reducing dopaminergic vesicle accumulation in the cell body. Similarly, in vivo neural recordings suggest an increase in calcium hyperpolarization currents in the CPu and PFC of intervention mice (−D2/+VDR) when compared with the parkinsonian mice (−D2). These animals (−D2/+VDR) also recorded an improvement in spatial working memory and motor function versus the Parkinsonian mice (−D2). These outcomes suggest the role of CPu-PFC corticostriatal outputs in the motor-cognitive decline seen in parkinsonian mice. Similarly, VDRA reduced the neural deficits through restoration of calcium currents (burst activities) in the intervention mice (−D2/+VDR). Conclusion: VDRA treatment reduced the motor-cognitive defects observed in haloperidol induced PD. Our findings suggest the role of VDRA in restoration of calcium currents associated with PFC and CPu corticostriatal outputs seen as burst frequencies in in vivo neural recording

Vitamin D 3 Receptor Activation Rescued Corticostriatal Neural Activity and Improved Motor Function in –D 2 R Tardive Dyskinesia Mice Model

Haloperidol-induced dyskinesia has been linked to a reduction in dopamine activity characterized by the inhibition of dopamine receptive sites on D2-receptor (D2R). As a result of D2R inhibition, calcium-linked neural activity is affected and seen as a decline in motor-cognitive function after prolonged haloperidol use in the treatment of psychotic disorders. In this study, we have elucidated the relationship between haloperidol-induced tardive dyskinesia and the neural activity in motor cortex (M1), basal nucleus (CPu), prefrontal cortex (PFC) and hippocampus (CA1). Also, we explored the role of Vitamin D3 receptor (VD3R) activation as a therapeutic target in improving motor-cognitive functions in dyskinetic mice. Dyskinesia was induced in adult BALB/c mice after 28 days of haloperidol treatment (10 mg/Kg; intraperitoneal). We established the presence of abnormal involuntary movements (AIMs) in the haloperidol treated mice (−D2) through assessment of the threshold and amplitude of abnormal involuntary movements (AIMs) for the Limbs (Li) and Orolingual (Ol) area (Li and Ol AIMs). As a confirmatory test, the dyskinetic mice (−D2) showed high global AIMs score when compared with the VD3RA intervention group (−D2/+VDR) for Li and Ol AIMs. Furthermore, in the behavioral tests, the dyskinetic mice exhibited a decrease in latency of fall (LOF; Rotarod-P < 0.05), climbing attempts (Cylinder test; P < 0.05) and latency of Turning (Parallel bar test; LOT-P < 0.05) when compared with the control. The reduced motor function in dyskinetic mice was associated with a decline in CPu-CA1 burst frequencies and an increase in M1-PFC cortical activity. However, after VD3RA intervention (−D2/+VDR), 100 mg/Kg for 7 days, CPu-CA1 burst activity was restored leading to a decrease in abnormal movement, and an increase in motor function. Ultimately, we deduced that VD3RA activation reduced the threshold of abnormal movement in haloperidol induced dyskinesia

Vitamin D 3 Receptor Activation Rescued Corticostriatal Neural Activity and Improved Motor - Cognitive Function in − D 2 R Parkinsonian Mice Model

fourth generation antipsychotics have been implicated in the blockade of calcium signalling through inhibition of dopamine receptive sites on dopaminergic D 2 Receptor (D 2 R). As a result of the abnormal calcium signalling associated with D 2 R inhibition, changes occur in the m o- tor and memory neural axis leading to the observed behavioural deficits after prolonged halope r- idol. Thus, Vitamin D 3 receptor (VD 3 R), a calcium controlling receptor in the striatum can be ta r- geted to relief the neurological symptoms associated with haloperidol ( − D 2 R) induced PD. Aim: This study sets to investigate the role of VD3R activation in vitro and in vivo after haloperidol - induced Dopaminergic (D 2 R) blockade. In addi tion, we examined the associated neural activity and behavioural changes in parkinsonian and VDRA intervention mice. Methods: Dopaminergic D 2 R inhibition was investigated in vitro using Melanocytes isolated from the scale of a Tilapia. In four separate set ups, the cells were cultured in calcium free Ringer’s solution as follows; 300 μM haloperidol, 100 μM VD 3 , 100 mM calcium chloride and a combination of 300 μM haloperidol and 100 μM VD 3 . Subsequently, dopaminergic vesicle accumulation and calcium signalling were observed in bright field microscopy using blue and green fluorescence probes. In the second phase, PD was induced in adult BALB/c mice ( − D 2 ; n = 8) after 14 days of intraperitoneal haloperidol treatment (10 mg/Kg). A set of n = 4 mice were untreated ( − D 2 ) while the other group (n = 4) r e- ceived 100 mg/Kg of VD 3 for 7 days ( − D 2 /+VDR). The control groups (n = 4 each) were treated with normal saline (NS) and VD 3 (+VDR) fo r 14 days. At the end of the treatment phase, the animals were assessed in Rotarod, parallel bar - , cylinder - , Y - Maze - , one trial place recognition - and novel object recognition - (NOR) tests. Neural activity was measured using chronic electrode implants plac ed in the M1 (motor cortex), CPu (striatum), CA1 (hippocampus) and PFC (prefrontal cortex). Neural activity was compared with the outcomes of behavioural tests for memory and motor fun c- tions and data was expressed as mean ± SEM (analysed using ANOVA with T ukey post - hoc test, significant level was set at 0.05). Results/Discussion: in vitro outcomes show that VDR increase calcium signalling and reverses the effect of haloperidol; specifically by reducing dopaminergic vesicle accumulation in the cell body. Sim ilarly, in vivo neural recordings suggest an increase in calcium hyperpolarization currents in the CPu and PFC of intervention mice ( − D 2 /+VDR) when compared with the parkinsonian mice ( − D 2 ). These animals ( − D 2 /+VDR) also recorded an i m- provement in spatial working memory and motor function versus the Parkinsonian mice ( − D 2 ). These outcomes suggest the role of CPu - PFC corticostriatal outputs in the motor - cognitive decline seen in parkinsonian mice. Similarly, VDRA reduced the neural deficits through restorati on of ca l- cium currents (burst activities) in the intervention mice ( − D 2 /+VDR). Conclusion: VDRA treatment reduced the motor - cognitive defects observed in haloperidol induced PD. Our findings suggest the role of VDRA in restoration of calcium currents assoc iated with PFC and CPu corticostriatal ou t- puts seen as burst frequencies in in vivo neural recording

Number preferences in lotteries

We explore people's preferences for numbers in large proprietary data sets from two different lottery games. We find that choice is far from uniform, and exhibits some familiar and some new tendencies and biases. Players favor personally meaningful and situationally available numbers, and are attracted towards numbers in the center of the choice form. Frequent players avoid winning numbers from recent draws, whereas infrequent players chase these. Combinations of numbers are formed with an eye for aesthetics, and players tend to spread their numbers relatively evenly across the possible range

Rural Community Power Structure: The Influence of Local Leaders on Community Decision Making in Ajaawa Community, Ogo Oluwa Local Government of Oyo State, Nigeria

Abstract: This study examines the influence of local leaders on community decision making in Ajaawa community in Ogo-Oluwa Local government of Oyo state. Data were collected from sixty respondents who are male and female leaders using structuredinterview schedule which was validated and pre-tested. Finding reveals that the mean age of respondent is 53 years; 80% are male while 20% are female. About 58% influence decisions made on some community project like town hall, postal agency, palace and market. Overall, their influence was either for (87.1%) or against (12.9%) these projects. About 67.5% encourage people to support the decision to embark on such projects; about 10.9% discourage people while 21.7% only gave their consent but made no direct contribution to influence members of the community. The main strategy employed for executing the projects were through launching, self labour and levies.Chi square analysis revealed a significant relationship between involvement/support for the project and gender (town hall, market), level of education (postal agencies, market), occupation (postal agencies), and marital status (palace)

Nutritional, Antinutritional Compositions And Organoleptic Analyses Of Raw And Blanched Cocoyam (Colocasia esculenta) Leaves

Abstract: This paper highlights the nutritional and antinutritional compositions of raw and blanched cocoyam leaves (Colocasia esculent

Determination of Sulphur Content in the Combustion Products from Artisanal Refineries in the Niger-Delta Region of Nigeria

This study investigated the air pollutants that are associated with combustion of refined petroleum products from artisanal refineries in Nigeria. It characterized refined petroleum products of petrol, diesel and kerosene from randomly selected artisanal refineries in the Niger Delta Region for quality and then characterized their combustion products for air pollutants. The air quality implication of the air pollutants associated with the combustion products of the refined petroleum products were then determined and the treatment methods that might be required to bring the quality of products from these refineries to the level where they can be air quality friendly were then identified. In this study, samples (Premium Motor Spirit (PMS), Automotive Gas Oil (AGO), and Household Kerosene (HHK)) were collected from thirty (30) local refinery in the Niger delta region of Nigeria and their sulphur content were examined to ascertain their conformity with the minimum requirements of the Standard Organisation of Nigeria (SON) and Department of Petroleum Refinery (DPR) on fuel quality. Gravimetric method using Eschka's mixture was used for sulphur content determination. The results showed that sulphur met the SON and DPR standards

Internet-based psychological interventions to improve mental health: Preference for and willingness to use among students in a Nigerian university

Objective: To assess the willingness and preference for Internet-Based Mental Health interventions among university students using a validated self-administered questionnaire, the Mental Health Literacy Questionnaire (MHLq) and the General Health Questionnaire (GHQ-12).Design: A cross-sectional multi-staged randomized study.Setting: The setting was the University of Ilorin, NigeriaSubjects: A total of 3,300 undergraduate students were assessed.Main Outcome Measures: The Statistical Package for Social Sciences (SPSS) software was used for data analysis. Descriptive and inferential statistics, and regression analysis to predict factors associated with willingness and preference was done. Level of significance was set at p-value of 0.05 and confidence interval at 95%.Results: Preference for Internet-Based Mental Health intervention compared to Face-to-Face intervention was 27.7% amongst the 3,179 analyzable questionnaires, while 48.6% respondents were willing to use Internet-Based Mental Intervention. Predictors of willingness to use internet-based support were monogamous family setting (aOR= 1.486), help seeking behaviour (aOR= 2.683) and probable mental illness (aOR= 0.333) while predictors of preference for Internet-Based Intervention over Face-to-Face therapy were younger age (aOR= 1.377), female gender (aOR =1.342), satisfactory relationship with mother and father (aOR = 1.607. 1. 466 respectively), self-help strategies (aOR= 0.713) and good knowledge of mental health (aOR =1.610).Conclusion: Internet-Based Interventions is a viable choice for improving university students’ mental health. Further studies may explore acceptability and use of different aspects of internet-based intervention

Understanding university community’s mental health needs and the determinants of wellbeing sequala: a qualitative study

Mental health among university students is on the increase every day, therefore this study investigates mental health needs and determinants of psychological well-being of the university community. This explanatory qualitative research design used a purposive sampling technique to sample 13-participant (with age-ranged between 21 to 57years; age mean=30.7years) at the University of Ilorin, Nigeria. Data was gathered using a key informant interview. Themes emerged from the data analysis, and excerpts from the participant interviews were used to illustrate the themes. Following data analysis, the research study found that the age of adolescents with emotional dysregulation, poor lecturers/students relationships, study life imbalance, and inaccessibility to counseling services were shown as the determinants of mental health among university students. Results revealed that there is a need for internet-based mental health services with substance abuse screening and audio/visual display facilities. Furthermore, empowerment of counseling staff, students, and the university community with periodic workshops/seminars on mental health awareness and integration of mental health modules into the General Studies (GNS) curriculum was found as the needs of the university community to boost their mental healthiness. We conclude that adolescence age, poor lecturer-student relationships, study life imbalance, and inaccessible counseling services are determinants of psychological distress. Therefore, insightful and rebranded interventions like e-mental health services and awareness programs are required to restore psychological wellbeing on the university campus