Human Nature and Social Order: A Comparative Critique of Hobbes and Locke

Central to most intellectual debates on political organization is the issue of human nature, for one’s understanding of it influences one’s prescriptions on how best society can be governed. This paper examines the contractarian theories of Hobbes and Locke in their attempts to identify the conditions for social order. Deploying a critical and comparative method, the paper identifies the failure of the two theories to recognize the complexity of human nature, a complexity which forecloses the plausibility of a descriptive straitjacket. The paper further argues that contrary to Hobbes’ pessimism and Locke’s optimism towards human nature, the individual has qualities which point to a delicate balance of both. Consequently, the paper highlights the imperatives of social order in a manner that accommodates the complexity of human nature. It concludes that it is on the basis of the appreciation of these dimensions of human nature that we can hope to evolve an enduring social order

Genetics of food intake, body weight and obesity - role of leptin

No Abstract. Nigerian Medical Practitioner Vol. 47(6) 2005: 108-11

Role of the heme oxygenases in abnormalities of the mesenteric circulation in cirrhotic rats

Carbon monoxide (CO), a product of heme metabolism by heme-oxygenase (HO), has biological actions similar to those of nitric oxide (NO). The role of CO in decreasing vascular responses to constrictor agents produced by experimental cirrhosis induced by carbon tetrachloride was evaluated before and after inhibition of HO with tin-mesoporphyrin (SnMP) in the perfused superior mesenteric vasculature (SMV) of cirrhotic and normal rats and in normal rats transfected with the human HO-1 (HHO-1) gene. Perfusion pressure and vasoconstrictor responses of the SMV to KCl, phenylephrine (PE), and endothelin-1 (ET-1) were decreased in cirrhotic rats. SnMP increased SMV perfusion pressure and restored the constrictor responses of the SMV to KCl, PE, and ET-1 in cirrhotic rats. The relative roles of NO and CO in producing hyporeactivity of the SMV to PE in cirrhotic rats were examined. Vasoconstrictor responses to PE were successively augmented by stepwise inhibition of CO and NO production, suggesting a complementary role for these gases in the regulation of reactivity of the SMV. Expression of constitutive but not of inducible HO (HO-1) was increased in the SMV of cirrhotic rats as was HO activity. Administration of adenovirus containing HHO-1 gene produced detection of HHO-1 RNA and increased HO activity in the SMV within 7 days. Rats transfected with HO-1 demonstrated reduction in both perfusion pressure and vasoconstrictor responses to PE in the SMV. We propose that HO is an essential component in mechanisms that modulate reactivity of the mesenteric circulation in experimental hepatic cirrhosis in rats