443 research outputs found
Alien Registration- Owens, Catherine (Greenville, Piscataquis County)
https://digitalmaine.com/alien_docs/8428/thumbnail.jp
Blended Learning Outcomes in Academic and Professional Writing
Much has been written about the potential of online learning. Advantages discussed in the literature include practical considerations such as career preparation, convenience, and savings in time and money, the ethical benefit of open access and the environmental one of reduced paper and printing; learning benefits such as improved creativity and support for a more learner centered environment, learner autonomy, and the establishment of standards. This study documents the learning outcomes of 28 undergraduate students studying Professional and Academic Writing in a blended learning environment. Outcomes reflect gains in academic English writing skills, with specific reference to the use of the process approach to writing. Evidence from students’e-portfolios provides a rich source of learners' engagement in the planning, drafting, revising and presenting steps of paper completion. Further evidence shows how students develop information literacy through the use of the online learning materials. The instructional design features of particular tasks along with the e-portfolio used for formative evaluation are also analyzed for their contributions to the learning outcomes
The effect of a unit in symbolic logic on the high school student's ability to grasp geometry concepts
Thesis (M.A.)--Boston UniversityThis study proposed to determine by experiment the effect of the study of symbolic logic on the student's achievement in geometry. Its secondary purpose was to test the influence of the study of logic on the student's ability to solve non-mathematical problems. As a means of teaching the nature and value of proof, the study presented a unit on symbolic logic taught in conjunction with geometry.
Current stress on concept as well as content, sustained interest in "the nature of proof," emphasis on the "foundations" in mathematics, and experiments with symbolic and Aristotelian logic all served to suggest the vitality of the problem and to set the direction for the experiment [TRUNCATED
Decorin-evoked paternally expressed gene 3 (PEG3) is an upstream regulator of the transcription factor EB (TFEB) in endothelial cell autophagy.
Macroautophagy is a fundamental and evolutionarily conserved catabolic process that eradicates damaged and aging macromolecules and organelles in eukaryotic cells. Decorin, an archetypical small leucine-rich proteoglycan, initiates a protracted autophagic program downstream of VEGF receptor 2 (VEGFR2) signaling that requires paternally expressed gene 3 (PEG3). We have discovered that PEG3 is an upstream transcriptional regulator of transcription factor EB (TFEB), a master transcription factor of lysosomal biogenesis, for decorin-evoked endothelial cell autophagy. We found a functional requirement of PEG3 for TFEB transcriptional induction and nuclear translocation in human umbilical vein endothelial and PAER2 cells. Mechanistically, inhibiting VEGFR2 or AMP-activated protein kinase (AMPK), a major decorin-activated energy sensor kinase, prevented decorin-evoked TFEB induction and nuclear localization. In conclusion, our findings indicate a non-canonical (nutrient- and energy-independent) mechanism underlying the pro-autophagic bioactivity of decorin via PEG3 and TFEB
Pre-purchase satisfaction of work shirts worn by women in agriculture.
As part of a larger comprehensive study on clothing preferences in women\u27s outdoor apparel, the purpose of this study is to assess the pre-purchase satisfaction of women participating in agriculture and to compare with functional, expressive, and aesthetic attributes, specific to shirts. From preliminary data analysis, shirts were identified as a major concern of the participants
European Society of Paediatric Radiology Computed Tomography and Dose Task Force : European guidelines on diagnostic reference levels for paediatric imaging
The recent European Council Directive 2013/59/EURATOM requires the establishment of diagnostic reference levels (DRLs) to optimise radiation dose in diagnostic and interventional radiology procedures. At the time this directive was enacted, just a few European countries had already set paediatric DRLs and many of these were outdated. For this reason, the European Commission launched a project addressing European Guidelines on Diagnostic Reference Levels for Paediatric Imaging that was awarded to a consortium led by the European Society of Radiology with the collaboration of the European Society of Paediatric Radiology and other European stakeholders involved in the radiation protection of children. The main aims of this project were to establish European DRLs to be used by countries without their own national paediatric DRLs and to provide a consistent method to establish new DRLs in the future. These European guidelines have been very recently endorsed by the European Commission and published in issue N degrees 185 of the Radiation Protection series. The purpose of this article is to introduce these guidelines to the wide community of paediatric radiologists.Peer reviewe
Defective Chylomicron Synthesis as a Cause of Delayed Particle Clearance in Diabetes?
Chylomicron metabolism is abnormal in diabetes and the chylomicron
particle may play a very important role in atherosclerosis.
The aim of this study was to examine the effect of diabetes
on the metabolism of chylomicrons in cholesterol-fed alloxan diabetic
and nondiabetic rabbits. Five diabetic rabbits and 5 control
rabbits were given [14C]linoleic acid and [3H]cholesterol by
gavage. Lymph was collected following cannulation of the lymph
duct and radiolabelled chylomicrons were isolated by ultracentrifugation.
The chylomicrons from each animal were injected into
paired control and diabetic recipients. Lymph apolipoprotein (apo)
B48, apo B100, and apo E were measured using sodium dodecyl
sulfate–polyacrylamide gradient gel electrophoresis. Mean blood
sugar of the diabetic donors and diabetic recipients were 19.7 ± 2.3
and 17.2 ± 3.2 mmol/L. Diabetic rabbits had significantly
raised plasma triglyceride (10.8 ± 13.9 versus 0.8 ± 0.5 mmol/L,
P < 0.02). There was a large increase in apo B48 in lymph chylomicrons
in the diabetic donor animals (0.19 ± 0.10 versus 0.04 ± 0.02
mg/h, P < 0.01) and apo B100 (0.22 ± 0.15 versus 0.07 ± 0.07 mg/h,
P < 0.05) and a reduction in apo E on the lymph chylomicron
particle (0.27 ± 0.01 versus 0.62 ± 0.07 mg/mg apo B, P < 0.001).
Diabetic recipients cleared both control and diabetic chylomicron
triglyceride significantly more slowly than control recipients
(P < 0.05). Clearance of control chylomicron cholesterol was delayed
when injected into diabetic recipients compared to when these
chylomicrons were injected into control recipients (P < 0.005).
Clearance of diabetic chylomicron cholesterol was significantly
slower when injected into control animals compared to control chylomicron injected into control animals (P < 0.02). In this animal
model of atherosclerosis, we have demonstrated that diabetes
leads to the production of an increased number of lipid and apo
E–deficient chylomicron particles. Chylomicron particles from the
control animals were cleared more slowly by the diabetic recipient
(both triglyceride and cholesterol). The chylomicron particles
obtained from the diabetic animals were cleared even more slowly
when injected into the diabetic recipient. Although there was an initial
delay in clearance of chylomicron triglyceride from the diabetic
particle when injected into the control animals, the clearance over
the first 15 minutes was not significantly different when compared
to the control chylomicron injected into the control animal. On the
other hand, the cholesterol clearance was significantly delayed.
Thus, diabetes resulted in the production of an increased number of
lipid- and apo E–deficient chylomicron particles. These alterations
account, in part, for the delay in clearance of these particles
Identifying the plant‐associated microbiome across aquatic and terrestrial environments: the effects of amplification method on taxa discovery
Plants in terrestrial and aquatic environments contain a diverse microbiome. Yet, the chloroplast and mitochondria organelles of the plant eukaryotic cell originate from free‐living cyanobacteria and Rickettsiales. This represents a challenge for sequencing the plant microbiome with universal primers, as ~99% of 16S rRNA sequences may consist of chloroplast and mitochondrial sequences. Peptide nucleic acid clamps offer a potential solution by blocking amplification of host‐associated sequences. We assessed the efficacy of chloroplast and mitochondria‐blocking clamps against a range of microbial taxa from soil, freshwater and marine environments. While we found that the mitochondrial blocking clamps appear to be a robust method for assessing animal‐associated microbiota, Proteobacterial 16S rRNA binds to the chloroplast‐blocking clamp, resulting in a strong sequencing bias against this group. We attribute this bias to a conserved 14‐bp sequence in the Proteobacteria that matches the 17‐bp chloroplast‐blocking clamp sequence. By scanning the Greengenes database, we provide a reference list of nearly 1500 taxa that contain this 14‐bp sequence, including 48 families such as the Rhodobacteraceae, Phyllobacteriaceae, Rhizobiaceae, Kiloniellaceae and Caulobacteraceae. To determine where these taxa are found in nature, we mapped this taxa reference list against the Earth Microbiome Project database. These taxa are abundant in a variety of environments, particularly aquatic and semiaquatic freshwater and marine habitats. To facilitate informed decisions on effective use of organelle‐blocking clamps, we provide a searchable database of microbial taxa in the Greengenes and Silva databases matching various n‐mer oligonucleotides of each PNA sequence.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138887/1/men12645.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138887/2/men12645_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138887/3/men12645-sup-0001-SupInfo.pd
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