ON THE USE OF PRODUCTIVITY-INCREASING TECHNOLOGIES IN SUB-SAHARAN AFRICA: THE CASE OF INLAND VALLEY SWAMP RICE FARMING IN SOUTHERN MALI

There is no improved seed-fertilizer technology available that can generate the needed growth in agricultural production in Sub-Saharan Africa to meet food demand by the rapidly increasing population. This paper identifies factors associated with inland valley swamp rice farmers' decisions to adopt "improved" varieties and/or fertilizer. To achieve this objective, input-specific logistic models were estimated using survey-generated data collected from a random sample of 221 rice plots (one per farmer) selected from a purposive sample of 12 Mali-Sud bas-fond villages during the 1995-96 cropping season. The model estimation results show that the farther the village is from the closest market, the lower the probability to adopt the "improved" variety, increasing the size of the rice plot will decrease this probability, and men are more likely to adopt "improved" varieties than women because men have access to credit through CMDT, and more alternative sources of income to finance input purchases than women. For fertilizer, the use of "improved" varieties, the presence of water control infrastructure, and the village experience in cotton production increase the likelihood that a farmer will apply this input. The significance of the village experience in cotton production and women limited access to credit suggests that one of the constrains to a wider use of modern inputs is the absence of a reliable source of these inputs and/or seasonal credits. The significance of village distance to the closest market and the presence of water control the likelihood of using these inputs suggests that there exits some technological payoff associated with well-functioning markets and road improvements because such investments reduce the effective distance between the farm and the market.Crop Production/Industries, Research and Development/Tech Change/Emerging Technologies,

CAN AGRICULTURAL PRODUCTION IN THE MARGINAL LANDS CONTRIBUTE TO IMPROVING FOOD SECURITY IN THE SAHELIAN AFRICAN COUNTRIES: AN EVIDENCE FROM THE BAS-FOND RICE PRODUCTION IN MALI

To improve national food security, successive Mali governments have always focused on expanding and intensifying production in the government-managed irrigation schemes (Office du Niger), which account for about 50% of domestic rice production. Because the cost of expanding and rehabilitating those schemes is high, the government is looking for complementary cost-effective ways to achieve this goal. The government could increase domestic rice supply by investing in improving the farmer-managed inland valley swamps. Although the government has paid little attention to those marginal lands, farmers have been growing rice in these areas using traditional technologies. This paper used data from a survey of 334 bas-fond farmers and secondary data to examine the potential contribution that these undeveloped bas-fonds could make to improve food security and rice exports in Mali. The study found that, if fully developed, the bas-fonds and flooded plains could produce more rice than is currently being supplied by the Office du Niger, or imported through commercial imports or food aid. As expected, rice yields in the bas-fonds are lower than in the Office du Niger. However, bas-fonds rice production is both financially profitable and provides a higher return per day of family labor than the competing upland crops (maize, sorghum/millet and cotton). In addition, the estimated domestic resources cost ratios show that, compared to the Office d u Niger, bas-fond rice production represents a better use of domestic resources, both for producing rice for home consumption and for the market.Crop Production/Industries, Food Security and Poverty, Land Economics/Use,

Potential for agronomical enhancement of millet yield via Jatropha curcas oilcake fertilizer amendment using placed application technique

This study carried out at the ICRISAT research station of Sadoré in Niger aimed at determining the impact of placed application technique of Jatropha oilcake on millet agronomic parameters. The experimental design was a randomised blocs including five treatments and four replicates. Control was plots without fertilizer while J_100 g, J_200 g, and J_300 gwere plots receiving 100 g , 200 g and 300 g of Jatropha oilcake respectively per seed hole and the plots NPK_6 g were receiving 6 g of NPK (15, 15, 15) per seed hole. ANOVA test was used for data analyses. Only the Control had significantly low number of tillers. At the end of the vegetative period J_300 g has the highest plants. J_300 g induced 196% increase of grain yield compared to the Control. The substitution of NPK (15,15,15) by 100 g, 200 g and 300 g of Jatropha oilcake per seed hole induced 79 - 52.93%, 92 – 72.23% and 152 – 100.65% increase of grain yield respectively compared to the Control in 2009 and 2010. With regard to the grain yield in 2009 and 2010, 100 g of Jatropha cake per seed hole can replace the current 6 g (NPK) per seed hole.Keywords: Jatropha oilcake, NPK (15, 15, 15), millet (H.K.P), placed application, fertilizer, Sadoré –Nige

OmpA family proteins and Pmp-like autotransporter: new adhesins of Waddlia chondrophila

Waddlia chondrophila is a obligate intracellular bacterium belonging to the Chlamydiales order, a clade that also includes the well-known classical Chlamydia responsible for a number of severe human and animal diseases. Waddlia is an emerging pathogen associated with adverse pregnancy outcomes in humans and abortion in ruminants. Adhesion to the host cell is an essential prerequisite for survival of every strict intracellular bacteria and, in classical Chlamydia, this step is partially mediated by polymorphic outer membrane proteins (Pmps), a family of highly diverse autotransporters that represent about 15% of the bacterial coding capacity. Waddlia chondrophila genome however only encodes one putative Pmp-like protein. Using a proteomic approach, we identified several bacterial proteins potentially implicated in the adhesion process and we characterized their expression during the replication cycle of the bacteria. In addition, we demonstrated that the Waddlia Pmp-like autotransporter as well as OmpA2 and OmpA3, two members of the extended Waddlia OmpA protein family, exhibit adhesive properties on epithelial cells. We hypothesize that the large diversity of the OmpA protein family is linked to the wide host range of these bacteria that are able to enter and multiply in various host cells ranging from protozoa to mammalian and fish cell

Cross-conservation of T-cell epitopes: Now even more relevant to (H7N9) influenza vaccine design

A novel avian-origin H7N9 influenza strain emerged in China in April 2013. Since its re-emergence in October–November 2013, the number of reported cases has accelerated; more than 220 laboratory-confirmed cases and 112 deaths (case fatality rate of 20–30%) have been reported. The resurgence of H7N9 has re-emphasized the importance of making faster and more effective influenza vaccines than those that are currently available. Recombinant H7 hemagglutinin (H7-HA) vaccines have been produced, addressing the first problem. Unfortunately, these recombinant subunit vaccine products appear to have failed to address the second problem, influenza vaccine efficacy. Reported unadjuvanted H7N9 vaccine seroconversion rates were between 6% and 16%, nearly 10-fold lower than rates for unadjuvanted vaccine seroconversion to standard H1N1 monovalent (recombinant) vaccine (89% to pandemic H1N1). Could this state of affairs have been predicted? As it turns out, yes, and it was. In that previous analysis of available H7-HA sequences, we found fewer T-cell epitopes per protein than expected, and predicted that H7-HA-based vaccines would be much less antigenic than recent seasonal vaccines. Novel approaches to developing a more immunogenic HA were offered for consideration at the time, and now, as the low immunogenicity of H7N9 vaccines appears to indicate, they appear to be even more relevant. More effective H7N9 influenza vaccines can be produced, provided that the role of T-cell epitopes is carefully considered, and accumulated knowledge about the importance of cross-conserved epitopes between viral subtypes is applied to the design of those vaccines

Manuel de formation sur la récupération biologique des terres dégradées

Dans le cadre du projet d’appui à la sécurité alimentaire des ménages (PASAM-TAI) au Niger, l’ONG CRS et ICRISAT ont conçu ce manuel de formation destiné aux femmes engagées dans la restauration biologique de terres dégradées. Cette approche intégrée combine techniques traditionnelles de conservation de l’eau (zaï, demi-lunes) avec la culture de légumes et arbres à haute valeur nutritive et commerciale. La technique BDL permet de produire entre autres okra, oseille, senne, pomme de Sahel, moringa sur des sols latéritiques en cours de désertification. L’impact sur les revenus, la nutrition familiale et l’indépendance économique des femmes est significatif

Surgical intervention on uterine fibromyoma in a country with limited resources: case of the gynaecology-obstetrics department of the Communal Medical Centre of Ratoma Conakry - Guinea

Background: In developing countries, treatment of uterine fibromyoma is confronted with numerous problems, namely: financial inaccessibility to the proposed treatments, fear of surgery and the weakness of the technical platform. The objectives of the study were to calculate the frequency of uterine fibromyomas, describe the socio-demographic characteristics of patients, identify the main clinical data and to describe the modalities of surgical management.Methods: It was a mixed descriptive study, cumulative over a period of 5 years (60 months) with data collection in two phases: a 4-year retrospective study from January 1, 2015 to December 31, 2018 and a 1-year prospective study from January 1, 2019 to December 31, 2019.Results: Authors collected 135 cases of uterine fibromyomas operated on out of a total of 260 cases of gynaecological pathologies, i.e. a frequency of 51.92%. Nulliparous women were the most concerned (45.18%), and women who attended school (60%) and those who did not attend school (40%). Women at home and housewives accounted for 42.20% and 54.07% respectively. Clinically, the circumstances of discovery were dominated by menometrorrhagia and menorrhagia respectively 77.77% and 68.14%. The large uterus was the most frequent physical sign found in 96.29% of cases. Uterine fibromyomas were recorded in 86.6% of cases in women with genital activity. The operative indications were dominated by the large polymyomatous uterus (64.44%), followed by hemorrhagic fibroma (18.52%) The surgical treatment was conservative in 92.60%. The total hysterectomy was performed in 7.40. Lethality was 1.4%.Conclusions: The surgical management of fibroids contrasts conservative treatment (myomectomy) with radical treatment (hysterectomy) with multiple possible approaches (hysteroscopy, vaginal surgery, laparoscopy or laparotomy). In this context, only laparotomy was possible due to lack of equipment. Laparoscopy and hysteroscopy equipment are necessary for less invasive surgery

Inhibitory humoral responses to the Plasmodium falciparum vaccine candidate EBA-175 are independent of the erythrocyte invasion pathway

Plasmodium falciparum utilizes multiple ligand-receptor interactions for invasion. The invasion ligand EBA-175 is being developed as a major blood-stage vaccine candidate. EBA-175 mediates parasite invasion of host erythrocytes in a sialic acid-dependent manner through its binding to the erythrocyte receptor glycophorin A. In this study, we addressed the ability of naturally acquired human antibodies against the EBA-175 RII erythrocyte-binding domain to inhibit parasite invasion of ex vivo isolates, in relationship to the sialic acid dependence of these parasites. We have determined the presence of antibodies to the EBA-175 RII domain by enzyme-linked immunosorbent assay (ELISA) in individuals from areas of Senegal where malaria is endemic with high and low transmission. Using affinity-purified human antibodies to the EBA-175 RII domain from pooled patient plasma, we have measured the invasion pathway as well as the invasion inhibition of clinical isolates from Senegalese patients in ex vivo assays. Our results suggest that naturally acquired anti-EBA-175 RII antibodies significantly inhibit invasion of Senegalese parasites and that these responses can be significantly enhanced through limiting other ligand-receptor interactions. However, the extent of this functional inhibition by EBA-175 antibodies is not associated with the sialic acid dependence of the parasite strain, suggesting that erythrocyte invasion pathway usage by parasite strains is not driven by antibodies targeting the EBA-175/glycophorin A interaction. This work has implications for vaccine design based on the RII domain of EBA-175 in the context of alternative invasion pathways