10492 Abstracts Collection -- Information-Centric Networking

From December 5th to 8th 2010, the Dagstuhl Seminar 10492 on "Information-Centric Networking" was held in Schloss Dagstuhl -- Leibniz Center for Informatics. During the seminar, several participants presented their current research, and ongoing work and open problems were discussed. Abstracts of the presentations given during the seminar as well as abstracts of seminar results and ideas are put together in this paper. The first section describes the seminar topics and goals in general. Links to extended abstracts or full papers are provided, if available

Adaptive Optical Burst Switching

International audienceWe propose a modified version of Optical Burst Switching (OBS) that adapts the size of switched data units to the network load. Specifically, we propose a two-way reservation OBS scheme in which every active source-destination pair attempts to reserve a lightpath and for every successful reservation, transmits an optical burst whose size is proportional to the number of active data flows. We refer to this technique as Adaptive Optical Burst Switching. We prove that the proposed scheme is optimal in the sense that the network is stable for all traffic intensities in the capacity region. We also evaluate the throughput and delay performance of adaptive OBS through both analysis and simulation in order to assess the practical load ranges at which the network may operate

Throughput-Delay Trade-Offs in Slotted WDM Ring Networks

International audienceWe analyse the throughput-delay trade-offs that arise in an optical burst-switched slotted WDM ring, where each node can transmit and receive on a subset of the available wavelengths. Specifically, we compare SWING, an access control scheme that combines opportunistic transmission and dynamic reservations, with a purely opportunistic access scheme. By means of analysis, we highlight the shortcomings of the opportunistic scheme in terms of load balancing and fairness. We then evaluate the performance of both schemes by simulation under several traffic scenarios and show that SWING yields a good throughput-delay trade-off

Targeting Hsp27/eIF4E interaction with phenazine compound: A promising alternative for castration-resistant prostate cancer treatment

The actual strategy to improve current therapies in advanced prostate cancer involves targeting genes activated by androgen withdrawal, either to delay or prevent the emergence of the castration-refractory phenotype. However, these genes are often implicated in several physiological processes, and long-term inhibition of survival proteins might be accompanied with cytotoxic effects. To avoid this problem, an alternative therapeutic strategy relies on the identification and use of compounds that disrupt specific protein-protein interactions involved in androgen withdrawal. Specifically, the interaction of the chaperone protein Hsp27 with the initiation factor eIF4E leads to the protection of protein synthesis initiation process and enhances cell survival during cell stress induced by castration or chemotherapy. Thus, in this work we aimed at i) identifying the interaction site of the Hsp27/eIF4E complex and ii) interfere with the relevant protein/protein association mechanism involved in castration-resistant progression of prostate cancer. By a combination of experimental and modeling techniques, we proved that eIF4E interacts with the C-terminal part of Hsp27, preferentially when Hsp27 is phosphorylated. We also observed that the loss of this interaction increased cell chemo-and hormone-sensitivity. In order to find a potential inhibitor of Hsp27/eIF4E interaction, BRET assays in combination with molecular simulations identified the phenazine derivative 14 as the compound able to efficiently interfere with this protein/protein interaction, thereby inhibiting cell viability and increasing cell death in chemo- and castration-resistant prostate cancer models in vitro and in vivo

10492 Executive Summary -- Information-Centric Networking

This document provides the executive summary of Dagstuhl seminar 10492 on Information-Centric Networking, which took place from December 5th to 8th 2010

Flow-Aware traffic control for a content-centric network,

International audienc

QUALITE DE SERVICE ET ROUTAGE DES FLOTS ELASTIQUES DANS UN RESEAU MULTISERVICE

PARIS-Télécom ParisTech (751132302) / SudocSudocFranceF

Measurement-based admission control for flow-aware implicit service differentiation

International audienceIt has previously been shown that the combined use of fair queuing and admission control would allow the Internet to provide satisfactory quality of service for both streaming and elastic flows without explicitly identifying traffic classes. In this paper we discuss the design of the required measurement based admission control (MBAC) scheme. The context is different to that of previous work on MBAC in that there is no prior knowledge of flow characteristics and there is a twofold objective: to maintain adequate throughput for elastic flows and to ensure low packet latency for any flow whose peak rate is less than a given threshold. In the paper we consider the second objective assuming realistically that most elastic and streaming flows are rate limited. We propose a MBAC algorithm and evaluate its performance by simulation under different stationary traffic mixes and in a flash crowd scenario. The algorithm is shown to offer a satisfactory compromise between flow performance and link utilization