6 research outputs found

    Contextual philosophy: Leopoldo Zea´s latin American history of philosophy as a starting-point and basis of latin American philosophy.

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    Die in drei strukturierte Teile gegliederte Dissertation ist insgesamt dem anspruchsvollen Projekt einer emanzipatorischen lateinamerikanischen Philosophie gewidmet. Ihre Struktur ergibt sich aus den drei Perspektiven, die vor allem im dritten Teil erkenntnisleitend sind: Bewusstseinsbildung, Erinnerung und Identität. This dissertation is dedicated to a highly demanded emancipated latin American philosophy. It is structurally divided into three parts. This structure dereves from three perspectives which are knowledge especially in the third part: formation of conscience, memory and identity

    Kontextuelle Philosophie: Die lateinamerikanische Geschichtsphilosophie des Leopoldo Zeas als Ausganspunkt und Grundlage einer lateinamerikanischen Philosophie.

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    Die in drei strukturierte Teile gegliederte Dissertation ist insgesamt dem anspruchsvollen Projekt einer emanzipatorischen lateinamerikanischen Philosophie gewidmet. Ihre Struktur ergibt sich aus den drei Perspektiven, die vor allem im dritten Teil erkenntnisleitend sind: Bewusstseinsbildung, Erinnerung und Identität. This dissertation is dedicated to a highly demanded emancipated latin American philosophy. It is structurally divided into three parts. This structure dereves from three perspectives which are knowledge especially in the third part: formation of conscience, memory and identity

    Prediction of Road Surface Quality during Cycling Using Smartphone Accelerometer Data

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    Many cyclists use online-maps for planning their routes, however, only little information is known about the road surface of different cycling paths, farm or public roads. Cyclists prefer road surfaces fitting the type of bike they are using for a specific ride (e.g., time trial, road, MTB, cyclocross, gravel bike). Often riders upload their ride data including GPS, heart rate (HR) or power (P) on platforms like Strava or Garmin Connect. In this research we tried to evaluate whether it is possible to (1) evaluate the road surface quality using a 3D accelerometer mounted on the bicycle’s fork (f = 500 Hz) and whether (2) results of similar quality can be achieved using the accelerometer of a smartphone (f = 100 Hz) placed in the cyclist’s pocket. For data acquisition a cyclist rode on a cyclocross bicycle on three different road surfaces (cobblestones, gravel and tarmac) with three different speeds (10, 20 and 30 km/h) and three different tire pressures (3, 4 and 5 bar). Data of both measuring systems were analyzed using machine learning algorithms. Results showed that road surfaces could be predicted with more than 99% accuracy with the accelerometer and with more than 97% with the smartphone-data

    MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation

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    The histone acetyl reader bromodomain-containing protein 4 (BRD4) is an important regulator of chromatin structure and transcription, yet factors modulating its activity have remained elusive. Here we describe two complementary screens for genetic and physical interactors of BRD4, which converge on the folate pathway enzyme MTHFD1 (methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1). We show that a fraction of MTHFD1 resides in the nucleus, where it is recruited to distinct genomic loci by direct interaction with BRD4. Inhibition of either BRD4 or MTHFD1 results in similar changes in nuclear metabolite composition and gene expression; pharmacological inhibitors of the two pathways synergize to impair cancer cell viability in vitro and in vivo. Our finding that MTHFD1 and other metabolic enzymes are chromatin associated suggests a direct role for nuclear metabolism in the control of gene expression

    B. Sprachwissenschaft.

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