Chromosome Numbers In Compositae Vii: Astereae Iii

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142139/1/ajb207543.pd

Partisan Profiles in Presidential Policies: an Extension of Presidential Preferences for Inflation versus Unemployment

In a recent article, Zaleski does not find any clear difference between the political preferences of Republican and Democratic administrations with respect to the choice between unemployment and inflation. This paper provides empirical support for the opposite conclusion in a generalization of Zaleski's approach allowing for instrument costs

Lensed or not lensed: Determining lensing magnifications for binary neutron star mergers from a single detection

Advanced LIGO and Advanced Virgo could observe the first lensed gravitational wave sources in the coming years, while the future Einstein Telescope could observe hundreds of lensed events. It is, therefore, crucial to develop methodologies to distinguish between lensed from unlensed gravitational-wave observations. A lensed signal not identified as such will lead to biases during the interpretation of the source. In particular, sources will appear to have intrinsically higher masses. No robust method currently exists to distinguish between the magnification bias caused by lensing and intrinsically high-mass sources. In this work, we show how to recognize lensed and unlensed binary neutron star systems through the measurement of their tidal effects for highly magnified sources as a proof-of-principle. The proposed method could be used to identify lensed binary neutron stars, which are the chief candidate for lensing cosmography studies. We apply our method on GW190425, finding no evidence in favor of lensing, mainly due to the poor measurement of the event's tidal effects. However, we expect that future detections with better tidal measurements can yield better constraints.Comment: 12 pages, 7 figure

Global surfaces of section in the planar restricted 3-body problem

The restricted planar three-body problem has a rich history, yet many unanswered questions still remain. In the present paper we prove the existence of a global surface of section near the smaller body in a new range of energies and mass ratios for which the Hill's region still has three connected components. The approach relies on recent global methods in symplectic geometry and contrasts sharply with the perturbative methods used until now.Comment: 11 pages, 1 figur

Comparison of Two Methods for Measurement of Horn Input Impedance

Two methods to measure the acoustic input impedance of a horn are compared. First method measures standing wave patterns in a tube which is loaded by the horn. The input impedance is calculated from the position of the first minimum in the standing wave pattern, and the ratio of maximum and minimum sound pressure level in the tube. Secondly we applied a direct method. A novel flow sensor, the microflown, is used together with a pressure microphone, which are mounted in the throat of the horn. Results from both measurements are compared with simulated models

Human Vault Nanoparticle Targeted Delivery of Antiretroviral Drugs to Inhibit Human Immunodeficiency Virus Type 1 Infection.

"Vaults" are ubiquitously expressed endogenous ribonucleoprotein nanoparticles with potential utility for targeted drug delivery. Here, we show that recombinant human vault nanoparticles are readily engulfed by certain key human peripheral blood mononuclear cells (PBMC), predominately dendritic cells, monocytes/macrophages, and activated T cells. As these cell types are the primary targets for human immunodeficiency virus type 1 (HIV-1) infection, we examined the utility of recombinant human vaults for targeted delivery of antiretroviral drugs. We chemically modified three different antiretroviral drugs, zidovudine, tenofovir, and elvitegravir, for direct conjugation to vaults. Tested in infection assays, drug-conjugated vaults inhibited HIV-1 infection of PBMC with equivalent activity to free drugs, indicating vault delivery and drug release in the cytoplasm of HIV-1-susceptible cells. The ability to deliver functional drugs via vault nanoparticle conjugates suggests their potential utility for targeted drug delivery against HIV-1