Electron Energy Distributions at Relativistic Shock Sites: Observational Constraints from the Cygnus A Hotspots

We report new detections of the hotspots in Cygnus A at 4.5 and 8.0 microns with the Spitzer Space Telescope. Together with detailed published radio observations and synchrotron self-Compton modeling of previous X-ray detections, we reconstruct the underlying electron energy spectra of the two brightest hotspots (A and D). The low-energy portion of the electron distributions have flat power-law slopes (s~1.5) up to the break energy which corresponds almost exactly to the mass ratio between protons and electrons; we argue that these features are most likely intrinsic rather than due to absorption effects. Beyond the break, the electron spectra continue to higher energies with very steep slopes s>3. Thus, there is no evidence for the `canonical' s=2 slope expected in 1st order Fermi-type shocks within the whole observable electron energy range. We discuss the significance of these observations and the insight offered into high-energy particle acceleration processes in mildly relativistic shocks.Comment: 5 pages, 3 figures, in Extragalactic Jets: Theory and Observation from Radio to Gamma Ray, Eds. T. A. Rector and D. S. De Youn

X-ray Emission Properties of Large Scale Jets, Hotspots and Lobes in Active Galactic Nuclei

We examine a systematic comparison of jet-knots, hotspots and radio lobes recently observed with Chandra and ASCA. This report will discuss the origin of their X-ray emissions and investigate the dynamics of the jets. The data was compiled at well sampled radio (5GHz) and X-ray frequencies (1keV) for more than 40 radio galaxies. We examined three models for the X-ray production: synchrotron (SYN), synchrotron self-Compton (SSC) and external Compton on CMB photons (EC). For the SYN sources -- mostly jet-knots in nearby low-luminosity radio galaxies -- X-ray photons are produced by ultrarelativistic electrons with energies 10-100 TeV that must be accelerated in situ. For the other objects, conservatively classified as SSC or EC sources, a simple formulation of calculating the ``expected'' X-ray fluxes under an equipartition hypothesis is presented. We confirmed that the observed X-ray fluxes are close to the expected ones for non-relativistic emitting plasma velocities in the case of radio lobes and majority of hotspots, whereas considerable fraction of jet-knots is too bright at X-rays to be explained in this way. We examined two possibilities to account for the discrepancy in a framework of the inverse-Compton model: (1) magnetic field is much smaller than the equipartition value, and (2) the jets are highly relativistic on kpc/Mpc scales. We concluded, that if the inverse-Compton model is the case, the X-ray bright jet-knots are most likely far from the minimum-power condition. We also briefly discuss the other possibility, namely that the observed X-ray emission from all of the jet-knots is synchrotron in origin.Comment: 20 pages, 10 figures, accepted for publication in the Astrophysical Journal, vol.62

Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2

The Ras oncogene products regulate the expression of genes in transformed cells, and members of the Ets family of transcription factors have been implicated in this process. To determine which Ets factors are the targets of Ras signaling pathways, the abilities of several Ets factors to activate Ras-responsive enhancer (RRE) reporters in the presence of oncogenic Ras were examined. In transient transfection assay, reporters containing RREs composed of Ets-AP-1 binding sites could be activated 30-fold in NIH 3T3 fibroblasts and 80-fold in the macrophage-like line RAW264 by the combination of Ets1 or Ets2 and Ras but not by several other Ets factors that were tested in the assay. Ets2 and Ras also superactivated an RRE composed of Ets-Ets binding sites, but the Ets-responsive promoter of the c-fms gene was not superactivated. Mutation of a threonine residue to alanine in the conserved amino-terminal regions of Ets1 and Ets2 (threonine 38 and threonine 72, respectively) abrogated the ability of each of these proteins to superactivate reporter gene expression. Phosphoamino acid analysis of radiolabeled Ets2 revealed that Ras induced normally absent threonine-specific phosphorylation of the protein. The Ras-dependent increase in threonine phosphorylation was not observed in Ets2 proteins that had the conserved threonine 72 residue mutated to alanine or serine. These data indicate that Ets1 and Ets2 are specific nuclear targets of Ras signaling events and that phosphorylation of a conserved threonine residue is a necessary molecular component of Ras-mediated activation of these transcription factors

On the Interaction of the PKS B1358-113 Radio Galaxy with the Abell 1836 Cluster

[abridged] Here we present the analysis of multifrequency data gathered for the FRII radio galaxy PKS B1358-113, hosted in the brightest cluster galaxy of Abell 1836. The galaxy harbors one of the most massive black holes known to date and our analysis of the optical data reveals that this black hole is only weakly active. Based on new Chandra and XMM-Newton X-ray observations and archival radio data we derive the preferred range for the jet kinetic luminosity $\sim (0.5-3) \times 10^{45}$ erg s$^{-1}$. This is above the values implied by various scaling relations proposed for radio sources in galaxy clusters, being instead very close to the maximum jet power allowed for the given accretion rate. We constrain the radio source lifetime as $\sim 40-70$ Myrs, and the total amount of deposited jet energy $\sim (2-8) \times 10^{60}$\,ergs. The detailed analysis of the X-ray data provides indication for the presence of a bow-shock driven by the expanding radio lobes into the Abell 1836 cluster environment, with the corresponding Mach number $\sim 2-4$. This, together with the recently growing evidence that powerful FRII radio galaxies may not be uncommon in the centers of clusters at higher redshifts, supports the idea that jet-induced shock heating may indeed play an important role in shaping the properties of clusters, galaxy groups, and galaxies in formation. We speculate on a possible bias against detecting jet-driven shocks in poorer environments, resulting from an inefficient electron heating at the shock front, combined with a relatively long electron-ion equilibration timescale.Comment: Version accepted to Ap

Cosmic ray diffusive acceleration at shock waves with finite upstream and downstream escape boundaries

In the present paper we discuss the modifications introduced into the first-order Fermi shock acceleration process due to a finite extent of diffusive regions near the shock or due to boundary conditions leading to an increased particle escape upstream and/or downstream the shock. In the considered simple example of the planar shock wave we idealize the escape phenomenon by imposing a particle escape boundary at some distance from the shock. Presence of such a boundary (or boundaries) leads to coupled steepening of the accelerated particle spectrum and decreasing of the acceleration time scale. It allows for a semi-quantitative evaluation and, in some specific cases, also for modelling of the observed steep particle spectra as a result of the first-order Fermi shock acceleration. We also note that the particles close to the upper energy cut-off are younger than the estimate based on the respective acceleration time scale. In Appendix A we present a new time-dependent solution for infinite diffusive regions near the shock allowing for different constant diffusion coefficients upstream and downstream the shock.Comment: LaTeX, 14 pages, 4 postscript figures; Solar Physics (accepted

Ets-2 and Components of Mammalian SWI/SNF Form a Repressor Complex That Negatively Regulates the BRCA1Promoter

Ets-2 is a transcriptional activator that can be modulated by ras-dependent phosphorylation. Evidence is presented indicating that ets-2 can also act as a transcriptional repressor. In the breast cancer cell line MCF-7, exogenous ets-2 repressed the activity of a BRCA1promoter-luciferase reporter dependent on a conserved ets-2-binding site in this promoter. Conditional overproduction of ets-2 in MCF-7 cells resulted in repression of endogenousBRCA1 mRNA expression. To address the mechanism by which ets-2 could act as a repressor, a biochemical approach was used to identify proteins that interacted with the ets-2 pointed domain. From this analysis, components of the mammalian SWI/SNF chromatin remodeling complex were found to interact with ets-2. Brg-1, the ATP-hydrolyzing component of the SWI/SNF complex, along with the BAF57/p50 and Ini1 subunits could be co-immunoprecipitated from cells with ets-2. The pointed domain of ets-2 directly interacted in vitro with the C-terminal region of Brg-1 in a phosphorylation-dependent manner. The combination ofBrg-1 and ets-2 could repress theBRCA1 promoter reporter in transfection assays. These results support a role for ets-2 as a repressor and indicate that components of the mammalian SNF/SWI complex are required as co-repressors

High Energy gamma-rays From FR I Jets

Thanks to Hubble and Chandra telescopes, some of the large scale jets in extragalactic radio sources are now being observed at optical and X-ray frequencies. For the FR I objects the synchrotron nature of this emission is surely established, although a lot of uncertainties - connected for example with the particle acceleration processes involved - remain. In this paper we study production of high energy gamma-rays in FR I kiloparsec-scale jets by inverse-Compton emission of the synchrotron-emitting electrons. We consider different origin of seed photons contributing to the inverse-Compton scattering, including nuclear jet radiation as well as ambient, stellar and circumstellar emission of the host galaxies. We discuss how future detections or non-detections of the evaluated gamma-ray fluxes can provide constraints on the unknown large scale jet parameters, i.e. the magnetic field intensity and the jet Doppler factor. For the nearby sources Centaurus A and M 87, we find measurable fluxes of TeV photons resulting from synchrotron self-Compton process and from comptonisation of the galactic photon fields, respectively. In the case of Centaurus A, we also find a relatively strong emission component due to comptonisation of the nuclear blazar photons, which could be easily observed by GLAST at energy ~10 GeV, providing important test for the unification of FR I sources with BL Lac objects.Comment: 39 pages, 6 figures included. Modified version, accepted for publication in Astrophysical Journa