Gluon chain formation in presence of static charges

We consider the origins of the gluon chain model. The model serves as a realization of the dynamics of the chromoelectric flux between static quark-antiquark sources. The derivation is based on the large-N_C limit of the Coulomb gauge Hamiltonian in the presence of a background field introduced to model magnetic confinement.Comment: 10 pages, 9 figure

Genome-wide signatures of population bottlenecks and diversifying selection in European wolves

Genomic resources developed for domesticated species provide powerful tools for studying the evolutionary history of their wild relatives. Here we use 61K single-nucleotide polymorphisms (SNPs) evenly spaced throughout the canine nuclear genome to analyse evolutionary relationships among the three largest European populations of grey wolves in comparison with other populations worldwide, and investigate genome-wide effects of demographic bottlenecks and signatures of selection. European wolves have a discontinuous range, with large and connected populations in Eastern Europe and relatively smaller, isolated populations in Italy and the Iberian Peninsula. Our results suggest a continuous decline in wolf numbers in Europe since the Late Pleistocene, and long-term isolation and bottlenecks in the Italian and Iberian populations following their divergence from the Eastern European population. The Italian and Iberian populations have low genetic variability and high linkage disequilibrium, but relatively few autozygous segments across the genome. This last characteristic clearly distinguishes them from populations that underwent recent drastic demographic declines or founder events, and implies long-term bottlenecks in these two populations. Although genetic drift due to spatial isolation and bottlenecks seems to be a major evolutionary force diversifying the European populations, we detected 35 loci that are putatively under diversifying selection. Two of these loci flank the canine platelet-derived growth factor gene, which affects bone growth and may influence differences in body size between wolf populations. This study demonstrates the power of population genomics for identifying genetic signals of demographic bottlenecks and detecting signatures of directional selection in bottlenecked populations, despite their low background variability.Heredity advance online publication, 18 December 2013; doi:10.1038/hdy.2013.122

The Serendipitous Discovery of a Group or Cluster of young Galaxies at z=2.40 in Deep Hubble Space Telescope WFPC2 Images

We report the serendipitous discovery of a group or cluster of young galaxies at $z\simeq$2.40 in a 24-orbit HST/WFPC2 exposure of the field around the weak radio galaxy 53W002. Potential cluster members were identified on ground-based narrow-band redshifted Ly$\alpha$ images and confirmed via spectroscopy. In addition to the known weak radio galaxy 53W002 at z=2.390, two other objects were found to have excess narrow-band Ly$\alpha$ emission at $z\simeq$2.40. Both have been spectroscopically confirmed, and one clearly contains a weak AGN. They are located within one arcminute of 53W002, or $\sim0.23h_{100}^{-1}$Mpc ($q_o$=0.5) at $z\simeq$2.40, which is the physical scale of a group or small cluster of galaxies. Profile fitting of the WFPC2 images shows that the objects are very compact, with scale lengths $\simeq$0\farcs 1 ($\simeq0.39h_{100}^{-1}$kpc), and are rather faint (luminosities < L*), implying that they may be sub-galactic sized objects. We discuss these results in the context of galaxy and cluster evolution and the role that weak AGN may play in the formation of young galaxies.Comment: Accepted for publication in The Astrophysical Journal (Letters). 13 pages of gzip compressed and uuencoded PS. Figures are available at http://www.phys.unsw.edu.au/~spd/bib.htm

The Three-Legged Stool of Voter Engagement

Disparities in voter turnout have increased significantly over the past four decades. Members of historically oppressed groups, those who are low-income, and or who have lower levels of education vote at significantly lower rates than white, wealthy and or more educated community members. These disparities correlate directly to political power and the eventual allocation of resources by elected officials. Therefore, eliminating these disparities through targeted voter engagement with client groups is particularly important for the profession of social work. This article describes the conceptualization of voter engagement as a three-legged stool, consisting of voter registration, regular voting, and basing voting decisions on self-interest. Without attention to all three legs, the potential for generating political power collapses, resulting in minimal influence on elected officials

The Top Ten List of Gravitational Lens Candidates from the HST Medium Deep Survey

A total of 10 good candidates for gravitational lensing have been discovered in the WFPC2 images from the HST Medium Deep Survey (MDS) and archival primary observations. These candidate lenses are unique HST discoveries, i.e. they are faint systems with sub-arcsecond separations between the lensing objects and the lensed source images. Most of them are difficult objects for ground-based spectroscopic confirmation or for measurement of the lens and source redshifts. Seven are ``strong lens'' candidates which appear to have multiple images of the source. Three are cases where the single image of the source galaxy has been significantly distorted into an arc. The first two quadruply lensed candidates were reported in Ratnatunga et al 1995 (ApJL, 453, L5) We report on the subsequent eight candidates and describe them with simple models based on the assumption of singular isothermal potentials. Residuals from the simple models for some of the candidates indicate that a more complex model for the potential will probably be required to explain the full structural detail of the observations once they are confirmed to be lenses. We also discuss the effective survey area which was searched for these candidate lens objects.Comment: 26 pages including 12 figures and 10 tables. AJ Vol. 117, No.

Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer.

Suppression of androgen receptor (AR) activity in prostate cancer by androgen depletion or direct AR antagonist treatment, although initially effective, leads to incurable castration-resistant prostate cancer (CRPC) via compensatory mechanisms including resurgence of AR and AR splice variant (ARV) signaling. Emerging evidence suggests that Sigma1 (also known as sigma-1 receptor) is a unique chaperone or scaffolding protein that contributes to cellular protein homeostasis. We reported previously that some Sigma1-selective small molecules can be used to pharmacologically modulate protein homeostasis pathways. We hypothesized that these Sigma1-mediated responses could be exploited to suppress AR protein levels and activity. Here we demonstrate that treatment with a small-molecule Sigma1 inhibitor prevented 5α- dihydrotestosterone-mediated nuclear translocation of AR and induced proteasomal degradation of AR and ARV, suppressing the transcriptional activity and protein levels of both full-length and splice-variant AR. Consistent with these data, RNAi knockdown of Sigma1 resulted in decreased AR levels and transcriptional activity. Furthermore, Sigma1 physically associated with ARV7 and A

New "Einstein Cross" Gravitational Lens Candidates in HST WFPC2 Survey Images

We report the serendipitous discovery of ``Einstein cross'' gravitational lens candidates using the Hubble Space Telescope. We have so far discovered two good examples of such lenses, each in the form of four faint blue images located in a symmetric configuration around a red elliptical galaxy. The high resolution of HST has facilitated the discovery of this optically selected sample of faint lenses with small (~1 arcsec) separations between the (I ~ 25-27) lensed components and the much brighter (I ~ 19-22) lensing galaxies. The sample has been discovered in the routine processing of HST fields through the Medium Deep Survey pipeline, which fits simple galaxy models to broad band filter images of all objects detected in random survey fields using WFPC2. We show that the lens configuration can be modeled using the gravitational field potential of a singular isothermal ellipsoidal mass distribution. With this model the lensing potential is very similar, both in ellipticity and orientation, to the observed light distribution of the elliptical galaxy, as would occur when stars are a tracer population. The model parameters and associated errors have been derived by 2-dimensional analysis of the observed images. The maximum likelihood procedure iteratively converges simultaneously on the model for the lensing elliptical galaxy and the source of the lensed components. A systematic search is in progress for other gravitational lens candidates in the HST Medium Deep Survey. This should eventually lead to a good statistical estimate for lensing probabilities, and enable us to probe the cosmological component of the observed faint blue galaxy population.Comment: Accepted for Astrophysical Journal Letters, 1995 November 1 LaTex, 10 pages, includes 2 figures 1 table, tarred gzip uuencoded using uufiles scrip