Impact of Ranch and Market Factors on an Index of Agricultural Holding Period Returns

This study develops nominal and real holding period return indices for operating ranches. The indices contain two components, monthly ranch operating profit and capital appreciation. A regression model that determines the effect of various attributes on total market value is used to estimate capital appreciation, and a second model determines operating profit. The two different ranch data series are compared with United States Long Term Government Bonds, the S&P 500 Index and Small Capitalization Stocks. Both ranch indices show very low correlation with the S&P 500 Index and very low or negative betas. Further, both ranch series have excess actual nominal and real returns when compared to expected returns determined from the Capital Asset Pricing Model.

The subpulse modulation properties of pulsars at 92 cm and the frequency dependence of subpulse modulation

A large sample of pulsars has been observed to study their subpulse modulation at an observing wavelength (when achievable) of both 21 and 92 cm using the Westerbork Synthesis Radio Telescope. In this paper we present the 92-cm data and a comparison is made with the already published 21-cm results. We analysed 191 pulsars at 92 cm using fluctuation spectra. The sample of pulsars is as unbiased as possible towards any particular pulsar characteristics. For 15 pulsars drifting subpulses are discovered for the first time and 26 of the new drifters found in the 21-cm data are confirmed. We discovered nulling for 8 sources and 8 pulsars are found to intermittently emit single pulses that have pulse energies similar to giant pulses. It is estimated that at least half of the total population of pulsars have drifting subpulses when observations with a high enough signal-to-noise ratio would be available. It could well be that the drifting subpulse mechanism is an intrinsic property of the emission mechanism itself, although for some pulsars it is difficult or impossible to detect. Drifting subpulses are in general found at both frequencies, although the chance of detecting drifting subpulses is possibly slightly higher at 92 cm. It appears that the youngest pulsars have the most disordered subpulses and the subpulses become more and more organized into drifting subpulses as the pulsar ages. The correlations with the modulation indices are argued to be consistent with the picture in which the radio emission can be divided in a drifting subpulse signal plus a quasi-steady signal which becomes, on average, stronger at high observing frequencies. The measured values of P3 at the two frequencies are highly correlated, but there is no evidence for a correlation with other pulsar parameters.Comment: 30 pages, 10 figures, accepted for publication in A&A, astro-ph version is missing 191 figures due to file size restrictions. Please download the appendix from http://www.astron.nl/~stappers/wiki/doku.php?id=resources:publication

Statistical competencies for medical research learners: What is fundamental?

IntroductionIt is increasingly essential for medical researchers to be literate in statistics, but the requisite degree of literacy is not the same for every statistical competency in translational research. Statistical competency can range from 'fundamental' (necessary for all) to 'specialized' (necessary for only some). In this study, we determine the degree to which each competency is fundamental or specialized.MethodsWe surveyed members of 4 professional organizations, targeting doctorally trained biostatisticians and epidemiologists who taught statistics to medical research learners in the past 5 years. Respondents rated 24 educational competencies on a 5-point Likert scale anchored by 'fundamental' and 'specialized.'ResultsThere were 112 responses. Nineteen of 24 competencies were fundamental. The competencies considered most fundamental were assessing sources of bias and variation (95%), recognizing one's own limits with regard to statistics (93%), identifying the strengths, and limitations of study designs (93%). The least endorsed items were meta-analysis (34%) and stopping rules (18%).ConclusionWe have identified the statistical competencies needed by all medical researchers. These competencies should be considered when designing statistical curricula for medical researchers and should inform which topics are taught in graduate programs and evidence-based medicine courses where learners need to read and understand the medical research literature

NF kappa B induces overexpression of bovine FcRn: a novel mechanism that further contributes to the enhanced immune response in genetically modified animals carrying extra copies of FcRn

Among the many functions of the neonatal Fc receptor (FcRn) for IgG, it binds to IgG-opsonized antigen complexes and propagates their traffic into lysosomes where antigen processing occurs. We previously reported that transgenic (Tg) mice and rabbits that carry multiple copies and overexpress FcRn have augmented humoral immune responses. Nuclear factor-kappa B (NFκB) is a critical molecule in the signaling cascade in the immune response. NFκB induces human FcRn expression and our previous in silico analysis suggested NFκB binding sites in the promoter region of the bovine (b) FcRn α-chain gene (FCGRT). Here, we report the identification of three NFκB transcription binding sites in the promoter region of this gene using luciferase reporter gene technology, electromobility shift assay and supershift analysis. Stimulation of primary bovine endothelial cells with the Toll like receptor-4 ligand lipopolysaccharide (LPS), which mediates its effect via NFκB, resulted in rapid upregulation of the bFcRn expression and a control gene, bovine E-selectin. This rapid bFcRn gene induction was also observed in the spleen of bFcRn Tg mice treated with intraperitoneally injected LPS, analyzed by northern blot analysis. Finally, NFκB- mediated bFcRn upregulation was confirmed at the protein level in macrophages isolated from the bFcRn Tg mice using flow cytometry with a newly developed FcRn specific monoclonal antibody that does not cross-react with the mouse FcRn. We conclude that NFκB regulates bFcRn expression and thus optimizes its functions, e.g., in the professional antigen presenting cells, and contributes to the much augmented humoral immune response in the bFcRn Tg mice