65 research outputs found
Estación Intermodal Atocongo - Nueva Centralidad Sur
El argumento del presente estudio de investigación radica en el funcionamiento de la Estación Intermodal de Atocongo - Vía Expresa Sur, teniendo como referencia los últimos proyectos de desarrollo urbanístico de Lima Metropolitana, enlazado con los sistemas de transportes actuales y proyectados, de esta forma generando nuevos equipamientos culturales, comerciales, deportivos, recuperando áreas verdes y de uso público que conecten dos bordes y perforen una gran barrera urbana que divide Lima, creando en conjunto un nuevo centro cívico en la zona sur de la ciudad
Measurement of CP violation parameters and polarisation fractions in decays
The first measurement of asymmetries in the decay and an updated measurement of its branching fraction and polarisation fractions are presented. The results are obtained using data corresponding to an integrated luminosity of of proton-proton collisions recorded with the LHCb detector at centre-of-mass energies of and . Together with constraints from , the results are used to constrain additional contributions due to penguin diagrams in the -violating phase , measured through decays to charmonium.The first measurement of CP asymmetries in the decay and an updated measurement of its branching fraction and polarisation fractions are presented. The results are obtained using data corresponding to an integrated luminosity of 3.0 fb^{−}^{1} of proton-proton collisions recorded with the LHCb detector at centre-of-mass energies of 7 and 8 TeV. Together with constraints from B → J/ψ ρ, the results are used to constrain additional contributions due to penguin diagrams in the CP -violating phase ϕ , measured through B decays to charmonium.The first measurement of asymmetries in the decay and an updated measurement of its branching fraction and polarisation fractions are presented. The results are obtained using data corresponding to an integrated luminosity of of proton-proton collisions recorded with the LHCb detector at centre-of-mass energies of and . Together with constraints from , the results are used to constrain additional contributions due to penguin diagrams in the -violating phase , measured through decays to charmonium
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
Summary
Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally.
Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies
have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of
the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income
countries globally, and identified factors associated with mortality.
Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to
hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis,
exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a
minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical
status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary
intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause,
in-hospital mortality for all conditions combined and each condition individually, stratified by country income status.
We did a complete case analysis.
Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital
diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal
malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome
countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male.
Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3).
Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income
countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups).
Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome
countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries;
p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients
combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11],
p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20
[1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention
(ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety
checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed
(ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of
parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65
[0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality.
Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome,
middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will
be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger
than 5 years by 2030
Estación Intermodal Atocongo - Nueva Centralidad Sur
Trabajo de suficiencia profesionalEl argumento del presente estudio de investigación radica en el funcionamiento de la Estación Intermodal de Atocongo - Vía Expresa Sur, teniendo como referencia los últimos proyectos de desarrollo urbanístico de Lima Metropolitana, enlazado con los sistemas de transportes actuales y proyectados, de esta forma generando nuevos equipamientos culturales, comerciales, deportivos, recuperando áreas verdes y de uso público que conecten dos bordes y perforen una gran barrera urbana que divide Lima, creando en conjunto un nuevo centro cívico en la zona sur de la ciudad
Servicios ecosistémicos: un enfoque introductorio con experiencias del occidente colombiano
Con el interés de transmitir y apropiar diversas comunidades en temáticas asociadas a los servicios ecosistémicos, el presente libro entrega 15 capítulos que aproximarán al lector hacia la conceptualización y apropiación de conocimientos básicos, asociados a los diversos servicios ecosistémicos brindados generosamente por la naturaleza. El capítulo 1, Introducción al estado del arte de los servicios ecosistémicos en la región occidental colombiana, introduce al lector hacia la apropiación conceptual de los servicios ecosistémicos, contando experiencias relevantes del contexto colombiano. Los 14 capítulos posteriores también tendrán una fase introductoria, estudios de caso basados en experiencias del occidente colombiano y resultados de investigaciones realizadas por los autores. En estos capítulos, el lector encontrará información relevante sobre cuatro grupos de servicios ecosistémicos: abastecimiento, regulación, apoyo y culturales. Este libro es el resultado del arduo trabajo consolidado por un equipo interdisciplinario que, a partir de la integración de saberes y resultados de investigación, logró construir un material de lenguaje sencillo que se espera sea de gran utilidad para diversos lectores interesados en apropiarse del conocimiento básico, orientado hacia la familiarización y el compromiso con la protección de los ecosistemas y sus servicios
Measurement of the mass and lifetime of the baryon
A proton-proton collision data sample, corresponding to an integrated luminosity of 3 fb collected by LHCb at and 8 TeV, is used to reconstruct , decays. Using the , decay mode for calibration, the lifetime ratio and absolute lifetime of the baryon are measured to be \begin{align*} \frac{\tau_{\Omega_b^-}}{\tau_{\Xi_b^-}} &= 1.11\pm0.16\pm0.03, \\ \tau_{\Omega_b^-} &= 1.78\pm0.26\pm0.04\pm0.05~{\rm ps}, \end{align*} where the uncertainties are statistical, systematic and from the calibration mode (for only). A measurement is also made of the mass difference, , and the corresponding mass, which yields \begin{align*} m_{\Omega_b^-}-m_{\Xi_b^-} &= 247.4\pm3.2\pm0.5~{\rm MeV}/c^2, \\ m_{\Omega_b^-} &= 6045.1\pm3.2\pm 0.5\pm0.6~{\rm MeV}/c^2. \end{align*} These results are consistent with previous measurements.A proton-proton collision data sample, corresponding to an integrated luminosity of 3 fb-1 collected by LHCb at s=7 and 8 TeV, is used to reconstruct 63±9 Ωb-→Ωc0π-, Ωc0→pK-K-π+ decays. Using the Ξb-→Ξc0π-, Ξc0→pK-K-π+ decay mode for calibration, the lifetime ratio and the absolute lifetime of the Ωb- baryon are measured to be τΩb-/τΞb-=1.11±0.16±0.03, τΩb-=1.78±0.26±0.05±0.06 ps, where the uncertainties are statistical, systematic and from the calibration mode (for τΩb- only). A measurement is also made of the mass difference, mΩb--mΞb-, and the corresponding Ωb- mass, which yields mΩb--mΞb-=247.4±3.2±0.5 MeV/c2, mΩb-=6045.1±3.2±0.5±0.6 MeV/c2. These results are consistent with previous measurements.A proton-proton collision data sample, corresponding to an integrated luminosity of 3 fb collected by LHCb at and 8 TeV, is used to reconstruct , decays. Using the , decay mode for calibration, the lifetime ratio and absolute lifetime of the baryon are measured to be \begin{align*} \frac{\tau_{\Omega_b^-}}{\tau_{\Xi_b^-}} &= 1.11\pm0.16\pm0.03, \\ \tau_{\Omega_b^-} &= 1.78\pm0.26\pm0.05\pm0.06~{\rm ps}, \end{align*} where the uncertainties are statistical, systematic and from the calibration mode (for only). A measurement is also made of the mass difference, , and the corresponding mass, which yields \begin{align*} m_{\Omega_b^-}-m_{\Xi_b^-} &= 247.4\pm3.2\pm0.5~{\rm MeV}/c^2, \\ m_{\Omega_b^-} &= 6045.1\pm3.2\pm 0.5\pm0.6~{\rm MeV}/c^2. \end{align*} These results are consistent with previous measurements
Observation of and decays and a measurement of the baryon mass
The decays and are observed in a data sample corresponding to an integrated luminosity of 3fb, collected in proton-proton collisions at 7 and 8TeV centre-of-mass energies by the LHCb detector. The mesons are reconstructed through the decay modes and . The branching fractions relative to that of are measured to be \begin{eqnarray*} \frac{\mathcal{B}(\Lambda_b^0 \to \psi(2S) pK^-)} {\mathcal{B}(\Lambda_b^0 \to J/\psi pK^-)} & = & (20.70\pm 0.76\pm 0.46\pm 0.37)\times10^{-2} \,, \frac{\mathcal{B}(\Lambda_b^0 \to J/\psi \pi^+ \pi^- pK^-)} {\mathcal{B}(\Lambda_b^0 \to J/\psi pK^-)} & = & (20.86\pm 0.96\pm 1.34)\times10^{-2} \,, \end{eqnarray*} where the first uncertainties are statistical, the second are systematic and the third is related to the knowledge of and branching fractions. The mass of the baryon is measured to beThe decays Λ → ψ(2S)pK and Λ → J/ψπ πpK are observed in a data sample corresponding to an integrated luminosity of 3 fb, collected in proton-proton collisions at 7 and 8 TeV centre-of-mass energies by the LHCb detector. The ψ(2S) mesons are reconstructed through the decay modes ψ(2S) → μμ and ψ(2S) → J/ψπ π.The decays and are observed in a data sample corresponding to an integrated luminosity of 3fb, collected in proton-proton collisions at 7 and 8TeV centre-of-mass energies by the LHCb detector. The mesons are reconstructed through the decay modes and . The branching fractions relative to that of are measured to be \begin{eqnarray*} \frac{\mathcal{B}(\Lambda_b^0 \to \psi(2S) pK^-)} {\mathcal{B}(\Lambda_b^0 \to J/\psi pK^-)} & = & (20.70\pm 0.76\pm 0.46\pm 0.37)\times10^{-2} \,, \frac{\mathcal{B}(\Lambda_b^0 \to J/\psi \pi^+ \pi^- pK^-)} {\mathcal{B}(\Lambda_b^0 \to J/\psi pK^-)} & = & (20.86\pm 0.96\pm 1.34)\times10^{-2} \,, \end{eqnarray*} where the first uncertainties are statistical, the second are systematic and the third is related to the knowledge of and branching fractions. The mass of the baryon is measured to be where the uncertainties are statistical and systematic
First observation of oscillations in decays and measurement of the associated coherence parameters
Charm meson oscillations are observed in a time-dependent analysis of the ratio of to decay rates, using data corresponding to an integrated luminosity of recorded by the LHCb experiment. The measurements presented are sensitive to the phase-space averaged ratio of doubly Cabibbo-suppressed to Cabibbo-favoured amplitudes and the product of the coherence factor and a charm mixing parameter . The constraints measured are , which is the most precise determination to date, and , which provides useful input for determinations of the CP-violating phase in decays. The analysis also gives the most precise measurement of the branching fraction, and the first observation of oscillations in this decay mode, with a significance of 8.2 standard deviations.Charm meson oscillations are observed in a time-dependent analysis of the ratio of D0→K+π-π+π- to D0→K-π+π-π+ decay rates, using data corresponding to an integrated luminosity of 3.0 fb-1 recorded by the LHCb experiment. The measurements presented are sensitive to the phase-space averaged ratio of doubly Cabibbo-suppressed to Cabibbo-favored amplitudes rDK3π and the product of the coherence factor RDK3π and a charm mixing parameter yK3π′. The constraints measured are rDK3π=(5.67±0.12)×10-2, which is the most precise determination to date, and RDK3πyK3π′=(0.3±1.8)×10-3, which provides useful input for determinations of the CP-violating phase γ in B±→DK±, D→K∓π±π∓π± decays. The analysis also gives the most precise measurement of the D0→K+π-π+π- branching fraction, and the first observation of D0–D¯0 oscillations in this decay mode, with a significance of 8.2 standard deviations.Charm meson oscillations are observed in a time-dependent analysis of the ratio of to decay rates, using data corresponding to an integrated luminosity of recorded by the LHCb experiment. The measurements presented are sensitive to the phase-space averaged ratio of doubly Cabibbo-suppressed to Cabibbo-favoured amplitudes and the product of the coherence factor and a charm mixing parameter . The constraints measured are , which is the most precise determination to date, and , which provides useful input for determinations of the CP-violating phase in decays. The analysis also gives the most precise measurement of the branching fraction, and the first observation of oscillations in this decay mode, with a significance of 8.2 standard deviations
- …