Choice of antihypertensive therapy in hypertensive patients with critical coronary artery stenosis

Sixty patients with stages II-III AH were studied. ABPM was performed in all the patients. DBPP was assessed by the degree of nocturnal BP lowering. Patients were randomized into groups receiving perindopril or losartan potassium. Perindopril was prescribed at a dose of 4 mg/day with subsequent rising up to 8 mg/day during 7 days. The initial dose of losartan potassium was 25 mg with subsequent rising up to 50 mg 2 times a day. The duration of observation was 8 weeks. Thus, perindopril therapy in hypertensive patients in the preoperative CABG period increased the number of people with normal BP profileyesБелгородский госуниверсите

Influence mechanisms of mineralocorticoid receptor antagonist (spironolactone) among elderly patients with chronic heartfailure against ischemic disease

It was determined that a significant positive dynamics of TNF-synthesis suppression by 67.0% (p 0.0001) was established in the 4th group of patients taking combined therapy with the blocker of mineralocorticoid receptors with spironolacton

Twenty-four-hour profile of peripheral and central blood pressure in young patients with high-normal blood pressure and hypertension

Aim. To evaluate indicators of daily monitoring of peripheral and central blood pressure in young patients with high-normal blood pressure (HNBP) and essential hypertension (HTN).Material and methods. One hundred twelve patients with HNBP or untreated hypertension aged 25-44 years were included. General clinical investigations were performed. An office blood pressure (BP) were assessed using an automatic BP monitor OMRON M2 Basic. Twenty-four-hour ambulotary BP monitoring (ABPM) on the brachial artery and aorta was carried out for 24 hours using the BpLAB system (OOO Petr Telegin) with an integrated Vasotens system. Depending on BP, patients were divided into groups: with HNBP and hypertension. Statistical processing and comparative analysis of the obtained data were carried out.Results. HNBP group consisted of 47 patients, while the HTN group consisted of 65 patients. The mean age of patients was 34,7±3,2 years. The parameters of daytime and nighttime peripheral BP had significant differences between the HNBP and HTN groups. Aortic BP monitoring revealed following differences: in patients with HTN, central BP values during the day and at night reflected higher values compared to patients from the HNBP group. The number of dippers for peripheral systolic blood pressure (SBP) was more by a quarter (p=0,038) in the HNBP group than in the HTN group. There were no differences in the reduction of diastolic blood pressure (DBP). The reduction in aortic SBP between the groups of HNBP and HTN were comparable. Among hypertensive patients, DBP dippers on the aorta were 20% higher (p=0,04) than in the HNBP group. According to the augmentation and the amplification index reduced to heart rate, there were no significant differences between the groups.Conclusion. Intergroup and intragroup differences were revealed depending on the types of 24-hour profile depending on peripheral and central BP. Reference values and predictive value of central BP require further research

Development of structural components of future technicians’ professional competencies during their studies of general disciplines in college

The relevance of the problem stems from the necessity to develop and implement the formation model for structural components of future technicians’ professional competencies during their studies of general professional disciplines. The purpose of the article is to carry out a theoretical study, to develop and approbate a model that forms the structural components of future maintenance and repair of automobile technicians’ professional competencies during their studies of general professional discipline “Materials science”. The leading method towards studies of this problem is technologies and methods of educational process modeling; works on educational research methodology. The article theoretically proves, develops and approbates a formation model for future maintenance and repair of automobiles technicians’ professional competencies during their studies of general professional discipline “Materials science”. This article may be useful for developing the competence-oriented content for training courses aimed at the formation of structural components of professional competencies. © 2016 Kopilov et al

Testing of chickens experimentally infected with A/H9N2 avian influenza virus isolates for their immune responses

Data on tests of chickens for their immune responses to infection with low pathogenic А/Н9N2 avian influenza virus isolates belonging to Y-280 and G1 genetic lines are presented in the paper. CD4⁺/CD8⁺ ratios were determined with flow cytometry for initial immune status examination and for detection of apparent immune system disorders. Quantitative analysis of peripheral blood lymphocyte subpopulations in chickens revealed changes characteristic of the immune suppression. Analysis of dynamics of T- and B-lymphocyte levels in blood of the infected chickens revealed decrease in relative T-lymphocyte counts and increase in relative B-lymphocyte counts. T-lymphocyte subpopulation composition expressed as CD4⁺/CD8⁺ ratio (%) changed after the infection: CD4⁺ cell proportion was found to decrease whereas CD8⁺ cell proportion increased. According to literature data, immune response activated by vaccination induces the reverse dynamics towards to increase in CD4⁺/CD8⁺ ratio. Both cell-mediated immunity and humoral immunity play role in development of the immune response in chickens infected with avian influenza viruses. Apparent humoral immune response was detected by serological tests of sera taken from chickens on day 14 after infection. Mean specific anti-A/H9N2 AIV antibody titre in all groups of test chickens infected with low pathogenic avian influenza virus isolates was higher than 6 log₂ . High level of specific antibodies to avian influenza virus was indicative of postvaccinal humoral immune response development

The Lake Baikal neutrino experiment: selected results

We review the present status of the lake Baikal Neutrino Experiment and present selected physical results gained with the consequetive stages of the stepwise increasing detector: from NT-36 to NT-96. Results cover atmospheric muons, neutrino events, very high energy neutrinos, search for neutrino events from WIMP annihilation, search for magnetic monopoles and environmental studies. We also describe an air Cherenkov array developed for the study of angular resolution of NT-200.Comment: 25 pages, 12 figures. To appear in the Procrrdings of International Conference on Non-Accelerator New Physics, June 28 - July 3, 1999, Dubna, Russi

The influence of agrotechnologies of organic farming on the content of humus, phosphorus and potassium in the soil

Abstract Organic agriculture is becoming an increasingly popular direction in modern agriculture. At the same time, some researchers and practitioners still have doubts about the ability of this technology to maintain the balance of nutrients in the soil. The article is a contribution to the study of the influence of long-term organic farming on agrochemical soil parameters. The aim of the study was to study the influence of organic farming technology on the content of humus, mobile forms of potassium and mobile forms of phosphorus in the soil of the most important components for fertility – humus, mobile forms of potassium and mobile forms of phosphorus in the non-carbonate chernozems of Western Siberia. The chernozems of Western Siberia are characterized by a high content of humus and nutrients, have optimal properties for agricultural crops. A statistically processed comparison of the quantitative content of humus, mobile forms of potassium and mobile forms of phosphorus in fields with long-term use of organic farming technology, and in similar fields where this technology was not used, was carried out. The article includes a brief geographical, geological, climatic characteristics of the place of the experiment, a description of the applied agricultural technologies and fertilizers. As a result, it was found that the use of organic farming technology has a positive effect on the state of soils, which is confirmed by an increase in the content of humus, mobile forms of potassium and mobile forms of phosphorus

Information Potential of the Collection of Documents «Professional-Pedagogical and Professional-Technical Education in Russia (1920-2020)»

В статье рассматривается информационный потенциал трехтомного сборника архивных документов по истории профессионально-технического и профессионально-педагогического образования, подготовленного преподавателями РГППУ.The article examines the information potential of a three-volume collection of archival documents on the history of vocational and vocational pedagogical education, prepared by the teachers of the Russian State Pedagogical University