Continuous and Simultaneous Measurement of Micro Multiphase Flow Using confocal Micro-Particle Image Velocimetry (Micro-PIV)

This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community, www.nanopaprika.eu.The objective of the paper is to present a “Multicolor Confocal Micro Particle Image Velocimetry (Micro-PIV)” technique to visualize and measure dynamic behavior of each phase of micro multiphase flow separately and simultaneously. The technique is applied to two types of micro two-phase flow. The first case is to investigate a mechanism of micro droplet formation at a micro T-shaped junction. The measurement data are compared to the numerical simulation using the CIP method. The second case is to investigate the tank-tread motion of red blood cell induced by the surrounding plasma flow

Shintani functions, real spherical manifolds, and symmetry breaking operators

For a pair of reductive groups $G \supset G'$, we prove a geometric criterion for the space $Sh(\lambda, \nu)$ of Shintani functions to be finite-dimensional in the Archimedean case. This criterion leads us to a complete classification of the symmetric pairs $(G,G')$ having finite-dimensional Shintani spaces. A geometric criterion for uniform boundedness of $dim Sh(\lambda, \nu)$ is also obtained. Furthermore, we prove that symmetry breaking operators of the restriction of smooth admissible representations yield Shintani functions of moderate growth, of which the dimension is determined for $(G, G') = (O(n+1,1), O(n,1))$.Comment: to appear in Progress in Mathematics, Birkhause

Accelerated epigenetic aging in Werner syndrome.

Individuals suffering from Werner syndrome (WS) exhibit many clinical signs of accelerated aging. While the underlying constitutional mutation leads to accelerated rates of DNA damage, it is not yet known whether WS is also associated with an increased epigenetic age according to a DNA methylation based biomarker of aging (the "Epigenetic Clock"). Using whole blood methylation data from 18 WS cases and 18 age matched controls, we find that WS is associated with increased extrinsic epigenetic age acceleration (p=0.0072) and intrinsic epigenetic age acceleration (p=0.04), the latter of which is independent of age-related changes in the composition of peripheral blood cells. A multivariate model analysis reveals that WS is associated with an increase in DNA methylation age (on average 6.4 years, p=0.011) even after adjusting for chronological age, gender, and blood cell counts. Further, WS might be associated with a reduction in naïve CD8+ T cells (p=0.025) according to imputed measures of blood cell counts. Overall, this study shows that WS is associated with an increased epigenetic age of blood cells which is independent of changes in blood cell composition. The extent to which this alteration is a cause or effect of WS disease phenotypes remains unknown