Take Me Back to the Garden of Love

[Verse 1] Sweet thoughts of first love are filling me,With joy but once we feel;While thoughts of fear are thrilling me,Its joy may prove unreal.Often ‘twould seem love is luring me,To find that you’re untrue;To have, you reassure me,In hope I long for you. [Chorus]Take me back to your Garden of Love, dear,Once again let me bloom in your heart,Take me back to the beautiful spring time,Where sunshine and love never part.To the rose in my heart that is dying,You are just like the dew from above,I need you, I want you, I love you,Take me back to your Garden of Love. [Verse 2] If in your heart you regret me not,Renew each vow to me;Just like a sweet forget-me-not,Once more each word will be.If in your dreams you could understand,Your love’s a fragrant bow’r;Your heart’s my key to wonderland,Come claim this fading flow’r. [Chorus]

Unfrustrated Qudit Chains and their Ground States

We investigate chains of 'd' dimensional quantum spins (qudits) on a line with generic nearest neighbor interactions without translational invariance. We find the conditions under which these systems are not frustrated, i.e. when the ground states are also the common ground states of all the local terms in the Hamiltonians. The states of a quantum spin chain are naturally represented in the Matrix Product States (MPS) framework. Using imaginary time evolution in the MPS ansatz, we numerically investigate the range of parameters in which we expect the ground states to be highly entangled and find them hard to approximate using our MPS method.Comment: 5 pages, 5 figures. Typos correcte

Keepers of the Metaphorical Gate: The Role of Journal Editors

Academic journals are central to a discipline’s professionalism and are the principal means of communication. The purpose of this symposium is explore the nature academic journals, their purposes and what they reveal about the field from the perspective of nine editors whose primary mission is to cover the broad field of adult education

Calcium-sensing receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

The calcium-sensing receptor (CaS, provisional nomenclature as recommended by NC-IUPHAR [44]) responds to multiple endogenous ligands, including extracellular calcium and other divalent/trivalent cations, polyamines and polycationic peptides, L-amino acids (particularly L-Trp and L-Phe), glutathione and various peptide analogues, ionic strength and extracellular pH (reviewed in [74]). While divalent/trivalent cations, polyamines and polycations are CaS receptor agonists [14, 106], L-amino acids, glutamyl peptides, ionic strength and pH are allosteric modulators of agonist function [34, 44, 58, 104, 105]. Indeed, L-amino acids have been identified as "co-agonists", with both concomitant calcium and L-amino acid binding required for full receptor activation [143, 51]. The sensitivity of the CaS receptor to primary agonists is increased by elevated extracellular pH [17] or decreased extracellular ionic strength [105]. This receptor bears no sequence or structural relation to the plant calcium receptor, also called CaS

Safety of Atrovent® CFC-free inhaler:respiratory events reported from an observational cohort study in England

ObjectivesThe aim of the study was to identify any unexpected clinical events associated with starting the new CFC‐free formulation of Atrovent® MDI in general practice in England.MethodsAn active surveillance cohort study was conducted with a focus on selected clinical events, including respiratory symptoms, in past users of Atrovent® CFC MDI (‘switchers’) and Atrovent® naïve users. Incidence density rate ratios (with 99% confidence intervals) for events occurring in the first 3 months of exposure (risk period‐ID1‐3) compared to 3 months prior to starting treatment (reference period‐IDR) were calculated.ResultsThe cohort consisted of 13 211 patients (median age 70 years, 50.1% female; 63.5% prior users of Atrovent® CFC MDI (‘switchers’)). Common respiratory events occurred at higher rates after starting treatment than before for switchers, for example lower respiratory tract infection (LRTI) [ID1/IDR = 1.45 (99% CI: 1.17, 1.81)] and worsening asthma [ID1/IDR = 1.58 (99% CI: 1.00, 2.51)]. Of these events only LRTI was significant for Atrovent® naïve patients [ID1/IDR = 1.42 (99% CI: 1.04, 1.95)].ConclusionsThe results of this study suggest effect modification of risk as a result of prior Atrovent® CFC MDI use. Overall, Atrovent® CFC‐free MDI appeared to be reasonably well tolerated in the immediate postmarketing period and the safety profile appeared similar to that of the CFC formulation

Calcium-sensing receptor in GtoPdb v.2023.1

The calcium-sensing receptor (CaS, provisional nomenclature as recommended by NC-IUPHAR [47] and subsequently updated [77]) responds to multiple endogenous ligands, including extracellular calcium and other divalent/trivalent cations, polyamines and polycationic peptides, L-amino acids (particularly L-Trp and L-Phe), glutathione and various peptide analogues, ionic strength and extracellular pH (reviewed in [78]). While divalent/trivalent cations, polyamines and polycations are CaS receptor agonists [14, 110], L-amino acids, glutamyl peptides, ionic strength and pH are allosteric modulators of agonist function [36, 47, 61, 108, 109]. Indeed, L-amino acids have been identified as "co-agonists", with both concomitant calcium and L-amino acid binding required for full receptor activation [149, 54]. The sensitivity of the CaS receptor to primary agonists is increased by elevated extracellular pH [18] or decreased extracellular ionic strength [109] while sensitivity is decreased by pathophysiological phosphate concentrations [20]. This receptor bears no sequence or structural relation to the plant calcium receptor, also called CaS