14 research outputs found
Thyr: a volumetric ray-marching tool for simulating microwave emission
Gyrosynchrotron radiation is produced by solar flares, and can be used to infer properties of the accelerated electrons and magnetic field of the flaring region. This microwave emission is highly dependent on many local plasma parameters, and the viewing angle. To correctly interpret observations, detailed simulations of the emission are required. Additionally, gyrosynchrotron emission from the chromosphere has been largely ignored in modelling efforts, and recent studies have shown the importance of thermal emission at millimetric wavelengths. Thyr is a new tool for modelling microwave emission from three-dimensional flaring loops with spatially varying atmosphere and increased resolution in the lower corona and chromosphere. Thyr is modular and open-source, consisting of separate components to compute the thermal and non-thermal microwave emission coefficients and perform three-dimensional radiative transfer (in local thermodynamic equilibrium). The radiative transfer integral is computed by a novel ray-marching technique to efficiently compute the contribution of many volume elements. This technique can also be employed on a variety of astrophysics problems. Herein we present a review of the theory of gyrosynchrotron radiation, and two simulations of identical flare loops in low- and high resolution performed with Thyr, with a spectral imaging analysis of differing regions. The high-resolution simulation presents a spectral hardening at higher frequencies. This hardening originates around the top of the chromosphere due to the strong convergence of the magnetic field, and is not present in previous models due to insufficient resolution. This hardening could be observed with a coordinated flare observation from active radio observatories
Deep learning for the Sun
Abstract John A Armstrong, Christopher M J Osborne and Lyndsay Fletcher examine how neural networks can be used to explore the nature and location of solar activity
Doppler dimming and brightening effects in solar prominences
We explored the impact that Doppler dimming and brightening effects from bulk motions of solar prominences have on the formation of Ly α, H α, and Mg II h line profiles. We compared two schemes in which these effects manifest; when the prominence is moving radially away from the solar surface (radial case), and when the prominence is moving parallel to the solar surface (horizontal case). To do this, we analysed 13,332 model profiles generated through the use of the 1D NLTE (i.e. departures from Local Thermodynamic equilibrium) radiative transfer (RT) code PROMWEAVER, built on the LIGHTWEAVER NLTE RT framework to mimic the behaviour and output of the 1D NLTE RT code PROM. We found that horizontal velocities are just as, or more important than radial velocities. This demonstrates that horizontal velocities need to be accounted for when attempting to do any sort of forward modelling
An impulsive geomagnetic effect from an early-impulsive flare
The geomagnetic “solar flare effect” (SFE) results from excess ionization in the Earth’s ionosphere, famously first detected at the time of the Carrington flare in 1859. This indirect detection of a flare constituted one of the first cases of “multimessenger astronomy,” whereby solar ionizing radiation stimulates ionospheric currents. Well-observed SFEs have few-minute time scales and perturbations of >10 nT, with the greatest events reaching above 100 nT. In previously reported cases the SFE time profiles tend to resemble those of solar soft X-ray emission, which ionizes the D-region; there is also a less-well-studied contribution from Lyman α. We report here a specific case, from flare SOL2024-03-10 (M7.4), in which an impulsive SFE deviated from this pattern. This flare contained an “early impulsive” component of exceptionally hard radiation, extending up to γ-ray energies above 1 MeV, distinctly before the bulk of the flare soft X-ray emission. We can characterize the spectral distribution of this early-impulsive component in detail, thanks to the modern extensive wavelength coverage. A more typical gradual SFE occurred during the flare’s main phase. We suggest that events of this type warrant exploration of the solar physics in the “impulse response” limit of very short time scales
The Lightweaver framework for nonlocal thermal equlibrum radiative transfer in Python
Tools for computing detailed optically thick spectral line profiles out of local thermodynamic equilibrium have always been focused on speed, due to the large computational effort involved. With the Lightweaver framework, we have produced a more flexible, modular toolkit for building custom tools in a high-level language, Python, without sacrificing speed against the current state of the art. The goal of providing a more flexible method for constructing these complex simulations is to decrease the barrier to entry and allow more rapid exploration of the field. In this paper we present an overview of the theory of optically thick nonlocal thermodynamic equilibrium radiative transfer, the numerical methods implemented in Lightweaver including the problems of time-dependent populations and charge-conservation, as well as an overview of the components most users will interact with, to demonstrate their flexibility
The Role of the 3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase Cytosolic Domain in Karmellae Biogenesis
Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort studyResearch in context
Summary: Background: The scale of COVID-19 and its well documented long-term sequelae support a need to understand long-term outcomes including frailty. Methods: This prospective cohort study recruited adults who had survived hospitalisation with clinically diagnosed COVID-19 across 35 sites in the UK (PHOSP-COVID). The burden of frailty was objectively measured using Fried's Frailty Phenotype (FFP). The primary outcome was the prevalence of each FFP group—robust (no FFP criteria), pre-frail (one or two FFP criteria) and frail (three or more FFP criteria)—at 5 months and 1 year after discharge from hospital. For inclusion in the primary analysis, participants required complete outcome data for three of the five FFP criteria. Longitudinal changes across frailty domains are reported at 5 months and 1 year post-hospitalisation, along with risk factors for frailty status. Patient-perceived recovery and health-related quality of life (HRQoL) were retrospectively rated for pre-COVID-19 and prospectively rated at the 5 month and 1 year visits. This study is registered with ISRCTN, number ISRCTN10980107. Findings: Between March 5, 2020, and March 31, 2021, 2419 participants were enrolled with FFP data. Mean age was 57.9 (SD 12.6) years, 933 (38.6%) were female, and 429 (17.7%) had received invasive mechanical ventilation. 1785 had measures at both timepoints, of which 240 (13.4%), 1138 (63.8%) and 407 (22.8%) were frail, pre-frail and robust, respectively, at 5 months compared with 123 (6.9%), 1046 (58.6%) and 616 (34.5%) at 1 year. Factors associated with pre-frailty or frailty were invasive mechanical ventilation, older age, female sex, and greater social deprivation. Frail participants had a larger reduction in HRQoL compared with before their COVID-19 illness and were less likely to describe themselves as recovered. Interpretation: Physical frailty and pre-frailty are common following hospitalisation with COVID-19. Improvement in frailty was seen between 5 and 12 months although two-thirds of the population remained pre-frail or frail. This suggests comprehensive assessment and interventions targeting pre-frailty and frailty beyond the initial illness are required. Funding: UK Research and Innovation and National Institute for Health Research
Guidelines for the use and interpretation of assays for monitoring autophagy
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field