23 research outputs found
The European monetary system - achievements and prospects. Address by F.-X. Ortoli, Vice-President of the Commission of the European Communities, at "The City and Europe - A ten-year appraisal," a conference organized by the Financial Times. London, 27-28 February 1984
Get PDFLes problems de l'identite monetaire et de l'integration financiere europeennes. Intervention de M. F.-X. Ortoli, Vice-President de la Commission des Communautes europeennes, congres du parti socialiste Italien sur l'ECU. Rome, 24 janvier 1984 = Problems of European monetary identity and financial integration. Speech by Mr. F.-X. Ortoli, Vice-President of the Commission, at the Congress of the Italian Socialist Party on the ECU. Rome, 24 January 1984
Get PDFCloning and evaluation of the role of rat GALR-2, a novel subtype of galanin receptor, in the control of pain perception
No full textUI - 99127125NRC publication: Ye
The first Lomé Convention between the EEC and ACP group revisited: bringing geopolitics back in
No full textCloning and Evaluation of the Role of Rat GALR-2, a Novel Subtype of Galanin Receptor, in the Control of Pain Perception
No full textPhospholipase Cβ3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain
No full textTreatment of neuropathic pain is a major clinical problem. This study shows expression of phospholipase ß3 (PLCß3) in mouse and human DRG neurons, mainly in small ones and mostly with a nonpeptidergic phenotype. After spared nerve injury, the pain threshold was strongly reduced, and systemic treatment of such animals with the unselective PLC inhibitor U73122 caused a rapid and long-lasting (48-h) increase in pain threshold. Thus, inhibition of PLC may provide a way to treat neuropathic pain
Binding of Chimeric Peptides M617 and M871 to Galanin Receptor Type 3 Reveals Characteristics of Galanin Receptor–Ligand Interaction
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Postendocytotic traffic of the galanin R1 receptor: A lysosomal signal motif on the cytoplasmic terminus
No full textThe neuropeptide galanin R1 receptor (GalR1) was tagged at its C terminus with EGFP (GalR1–EGFP) to study receptor localization and trafficking. In PC12 and HEK293 cells, functional GalR1–EGFP was expressed on the plasma membrane and internalized into cytoplasmic vesicles after galanin stimulation. The internalization was blocked by 0.4 M sucrose and by silencing of clathrin with siRNA methodology. Internalized GalR1–EGFP and LysoTracker, a lysosomal marker, overlapped in intracellular vesicles after prolonged galanin stimulation. This colocalization was strongly reduced after site-directed mutagenesis of the motif YXXØ on the C terminus of GalR1 (where Ø is a bulky hydrophobic residue and X any amino acid). Taken together, these data suggest that GalR1 is internalized via the clathrin-dependent, endocytic pathway and then, to a large extent, delivered to lysosomes for degradation through the lysosome-targeting signal YXXØ
