12CO and 13CO J=3-2 observations toward N11 in the Large Magellanic Cloud

After 30 Doradus, N11 is the second largest and brightest nebula in the LMC. This large nebula has several OB associations with bright nebulae at its surroundings. N11 was previously mapped at the lowest rotational transitions of $^{12}$CO (J=1--0 and 2--1), and in some particular regions pointings of the $^{13}$CO J=1--0 and 2--1 lines were also performed. Using ASTE we mapped the whole extension of the N11 nebula in the $^{12}$CO J=3--2 line, and three sub-regions in the $^{13}$CO J=3--2 line. The regions mapped in the $^{13}$CO J=3--2 were selected based on that they may be exposed to the radiation at different ways: a region lying over the nebula related to the OB association LH10 (N11B), another one that it is associated with the southern part of the nebula related to the OB association LH13 (N11D), and finally a farther area at the southwest without any embedded OB association (N11I). We found that the morphology of the molecular clouds lying in each region shows some signatures that could be explained by the expansion of the nebulae and the action of the radiation. Fragmentation generated in a molecular shell due to the expansion of the N11 nebula is suggested. The integrated line ratios $^{12}$CO/$^{13}$CO show evidences of selective photodissociation of the $^{13}$CO, and probably other mechanisms such as chemical fractionation. The CO contribution to the continuum at 870 $\mu$m was directly derived. The distribution of the integrated line ratios $^{12}$CO J=3--2/2--1 show hints of stellar feedback in N11B and N11D. The ratio between the virial and LTE mass (M$_{\rm vir}$/M$_{\rm LTE}$) is higher than unity in all analyzed molecular clumps, which suggests that the clumps are not gravitationally bounded and may be supported by external pressure. A non-LTE analysis suggests that we are mapping gas with densities about a few 10$^{3}$ cm$^{-3}$.Comment: Accepted to be published in A&A. Figures were degrade

Planning with Information-Processing Constraints and Model Uncertainty in Markov Decision Processes

Information-theoretic principles for learning and acting have been proposed to solve particular classes of Markov Decision Problems. Mathematically, such approaches are governed by a variational free energy principle and allow solving MDP planning problems with information-processing constraints expressed in terms of a Kullback-Leibler divergence with respect to a reference distribution. Here we consider a generalization of such MDP planners by taking model uncertainty into account. As model uncertainty can also be formalized as an information-processing constraint, we can derive a unified solution from a single generalized variational principle. We provide a generalized value iteration scheme together with a convergence proof. As limit cases, this generalized scheme includes standard value iteration with a known model, Bayesian MDP planning, and robust planning. We demonstrate the benefits of this approach in a grid world simulation.Comment: 16 pages, 3 figure

Hormonal regulation of female reproduction

Reproduction is an event that requires the coordination of peripheral organs with the nervous system to ensure that the internal and external environments are optimal for successful procreation of the species. This is accomplished by the hypothalamic-pituitary-gonadal axis that coordinates reproductive behavior with ovulation. The primary signal from the central nervous system is gonadotropin-releasing hormone (GnRH), which modulates the activity of anterior pituitary gonadotropes regulating follicle stimulating hormone (FSH) and luteinizing hormone (LH) release. As ovarian follicles develop they release estradiol, which negatively regulates further release of GnRH and FSH. As estradiol concentrations peak they trigger the surge release of GnRH, which leads to LH release inducing ovulation. Release of GnRH within the central nervous system helps modulate reproductive behaviors providing a node at which control of reproduction is regulated. To address these issues, this review focuses on several critical questions. How is the HPG axis regulated in species with different reproductive strategies? What internal and external conditions modulate the synthesis and release of GnRH? How does GnRH modulate reproductive behavior within the hypothalamus? How does disease shift the activity of the HPG axis.Fil: Christensen, A.. University of California at Los Angeles; Estados UnidosFil: Bentley, G. E.. University of California at Berkeley; Estados UnidosFil: Cabrera Kreiker, Ricardo Jorge. Universidad de Mendoza; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Litoral; ArgentinaFil: Perfito, N.. University of California at Berkeley; Estados UnidosFil: Wu, T. J.. Uniformed Services University Of The Health Sciences; Estados UnidosFil: Micevych, P.. University of California at Los Angeles; Estados Unido

Solubility of three natural compounds with insecticidal activity in supercritical carbon dioxide: Experimental measurements and predictive modeling with the GC-EoS

In this work, the solubility of thymoquinone, R-(+)-pulegone and 1-octen-3-ol in supercritical CO2 is determined in a range of conditions typical of supercritical fluid processes such as extraction, fractionation and impregnation. These compounds were selected based in their insecticidal activity which may enable to apply them as biopesticides. Solubility was measured using a semicontinuos method in the temperature range of 45–65 °C and pressure of 8–12 MPa, at a CO2 flowrate of 0.05–0.10 g/min, which was verified to be low enough to ensure saturation. Solubilities were predicted using the Group Contribution Equation of State (GC-EoS) and compared to the experimental results, with a good agreement. Consistency of the data was tested using the density-based Chrastil equation

Looking for evidence of high-mass star formation at core scale in a massive molecular clump

We present a comprehensive physical and chemical study of the fragmentation and star formation activity towards the massive clump AGAL G338.9188+0.5494 harbouring the extended green object EGO 338.92+0.55(b). The presence of an EGO embedded in a massive clump, suggests, at clump scale, that high-mass star formation is occurring. The main goal of this work is to find evidence of such high-mass star formation, but at core scale. Using mm observations of continuum and lines obtained from the ALMA database at Bands 6 and 7, we study the substructure of the massive clump. The angular resolution of the data is about 0.5'', which allow us to resolve structures of about 0.01pc ($\sim$ 2000 au) at the distance of 4.4 kpc. The continuum emission at 340 GHz reveals that the molecular clump is fragmented in five cores, labeled from C1 to C5. The $^{12}$CO J=3--2 emission shows the presence of molecular outflows related to three of them. The analysis of the CH$_3$CN and CH$_3$CCH emissions suggests temperatures of about 340 and 72~K, respectively, for C1, showing that the methyl cyanide would trace a gas layer closer to the protostar than the methyl acetylene. The obtained mass of core C1 ranges from 3 to 10 M$_{\odot}$. We found that the discovered molecular outflow arising from core C1 should be the main responsible for the 4.5 $\mu$m extended emission. The average mass and energy of such a molecular outflow is about 0.5 M$_{\odot}$~and $10^{46}$~erg, respectively, which suggest that 10 M$_{\odot}$ is the most likely mass value for core C1. Additionally we found that the region is chemically very rich with several complex molecular species. Particularly, from the analysis of the CN emission we found strong evidence that such a radical is indirectly tracing the molecular outflows, more precisely the border of the cavity walls carved out by such outflows.Comment: Accepted for publication in A&A (July 5, 2023

Detection of pediatric upper extremity motor activity and deficits with accelerometry

Importance: Affordable, quantitative methods to screen children for developmental delays are needed. Motor milestones can be an indicator of developmental delay and may be used to track developmental progress. Accelerometry offers a way to gather real-world information about pediatric motor behavior. Objective: To develop a referent cohort of pediatric accelerometry from bilateral upper extremities (UEs) and determine whether movement can accurately distinguish those with and without motor deficits. Design, Setting, and Participants: Children aged 0 to 17 years participated in a prospective cohort from December 8, 2014, to December 29, 2017. Children were recruited from Ranken Jordan Pediatric Bridge Hospital, Maryland Heights, Missouri, and Washington University School of Medicine in St Louis, St Louis, Missouri. Typically developing children were included as a referent cohort if they had no history of motor or neurological deficit; consecutive sampling and matching ensured equal representation of sex and age. Children with diagnosed asymmetric motor deficits were included in the motor impaired cohort. Exposures: Bilateral UE motor activity was measured using wrist-worn accelerometers for a total of 100 hours in 25-hour increments. Main Outcomes and Measures: To characterize bilateral UE motor activity in a referent cohort for the purpose of detecting irregularities in the future, total activity and the use ratio between UEs were used to describe typically developing children. Asymmetric impairment was classified using the mono-arm use index (MAUI) and bilateral-arm use index (BAUI) to quantify the acceleration of unilateral movements. Results: A total of 216 children enrolled, and 185 children were included in analysis. Of these, 156 were typically developing, with mean (SD) age 9.1 (5.1) years and 81 boys (52.0%). There were 29 children in the motor impaired cohort, with mean (SD) age 7.4 (4.4) years and 16 boys (55.2%). The combined MAUI and BAUI (mean [SD], 0.86 [0.005] and use ratio (mean [SD], 0.90 [0.008]) had similar F1 values. The area under the curve was also similar between the combined MAUI and BAUI (mean [SD], 0.98 [0.004]) and the use ratio (mean [SD], 0.98 [0.004]). Conclusions and Relevance: Bilateral UE movement as measured with accelerometry may provide a meaningful metric of real-world motor behavior across childhood. Screening in early childhood remains a challenge; MAUI may provide an effective method for clinicians to measure and visualize real-world motor behavior in children at risk for asymmetrical deficits