Equilibrium and dynamics of a trapped superfluid Fermi gas with unequal masses

Interacting Fermi gases with equal populations but unequal masses are investigated at zero temperature using local density approximation and the hydrodynamic theory of superfluids in the presence of harmonic trapping. We derive the conditions of energetic stability of the superfluid configuration with respect to phase separation and the frequencies of the collective oscillations in terms of the mass ratio and the trapping frequencies of the two components. We discuss the behavior of the gas after the trapping potential of a single component is switched off and show that, near a Feshbach resonance, the released component can still remain trapped due to many-body interaction effects. Explicit predictions are presented for a mixture of $^6$Li and $^{40}$K with resonant interaction.Comment: 4 pages, 2 figure

Umklapp collisions and center of mass oscillation of a trapped Fermi gas

Starting from the the Boltzmann equation, we study the center of mass oscillation of a harmonically trapped normal Fermi gas in the presence of a one-dimensional periodic potential. We show that for values of the the Fermi energy above the first Bloch band the center of mass motion is strongly damped in the collisional regime due to umklapp processes. This should be contrasted with the behaviour of a superfluid where one instead expects the occurrence of persistent Josephson-like oscillations.Comment: 11 pages, 3 figures, corrected typo

Sound propagation and oscillations of a superfluid Fermi gas in the presence of a 1D optical lattice

We develop the hydrodynamic theory of Fermi superfluids in the presence of a periodic potential. The relevant parameters governing the propagation of sound (compressibility and effective mass) are calculated in the weakly interacting BCS limit. The conditions of stability of the superfluid motion with respect to creation of elementary excitations are discussed. We also evaluate the frequency of the center of mass oscillation when the superfluid gas is additionally confined by a harmonic trap.Comment: Version accepted in Phys. Rev. A. It contains a discussion on the dynamical instability of Fermi superfluids in optical lattice

Landau-Zener sweeps and sudden quenches in coupled Bose-Hubbard chains

We simulate numerically the dynamics of strongly correlated bosons in a two-leg ladder subject to a time-dependent energy bias between the two chains. When all atoms are initially in the leg with higher energy, we find a drastic reduction of the inter-chain particle transfer for slow linear sweeps, in quantitative agreement with recent experiments. This effect is preceded by a rapid broadening of the quasi-momentum distribution of atoms, signaling the presence of a bath of low-energy excitations in the chains. We further investigate the scenario of quantum quenches to fixed values of the energy bias. We find that for large enough density the momentum distribution relaxes to that of an equilibrium thermal state with the same energy.Comment: 6 pages, 4 figure

Endotracheal intubation to reduce aspiration events in acutely comatose patients: a systematic review

Background: It is customary to believe that a patient with a Glasgow Coma Scale (GCS) score less than or equal to 8 should be intubated to avoid aspiration. We conducted a systematic review to establish if patients with GCS 64 8 for trauma or non-traumatic emergencies and treated in the acute care setting (e.g., Emergency Department or Pre-hospital environment) should be intubated to avoid aspiration or aspiration pneumonia/pneumonitis, and consequently, reduce mortality. Methods: We searched six databases, Pubmed, Embase, Scopus, SpringerLink, Cochrane Library, and Ovid Emcare, from April 15th to October 14th, 2020, for studies involving low GCS score patients of whom the risk of aspiration and related complications was assessed. Results: Thirteen studies were included in the final analysis (7 on non-traumatic population, 4 on trauma population, 1 pediatric and 1 adult mixed case studies). For the non-traumatic cases, two prospective studies and one retrospective study found no difference in aspiration risk between intubated and non-intubated patients. Two retrospective studies reported a reduction in the risk of aspiration in the intubated patient group. For traumatic cases, the study that considered the risk of aspiration did not show any differences between the two groups. A study on adult mixed cases found no difference in the incidence of aspiration among intubated and non-intubated patients. A study on pediatric patients found increased mortality for intubated versus non-intubated non-traumatic patients with a low GCS score. Conclusion: Whether intubation results in a reduction in the incidence of aspiration events and whether these are more frequent in patients with low GCS scores are not yet established. The paucity of evidence on this topic makes clinical trials justifiable and necessary. Trial registration: Prospero registration number: CRD42020136987

miR-214 coordinates melanoma progression by upregulating ALCAM through TFAP2 and miR-148b downmodulation.

Malignant melanoma is one of the most aggressive human cancers, but the mechanisms governing its metastatic dissemination are not fully understood. Upregulation of miR-214 and ALCAM and the loss of TFAP2 expression have been implicated in this process, with TFAP2 a direct target of miR-214. Here, we link miR-214 and ALCAM as well as identify a core role for miR-214 in organizing melanoma metastasis. miR- 214 upregulated ALCAM, acting transcriptionally through TFAP2 and also posttranscriptionally through miR-148b (itself controlled by TFAP2), both negative regulators of ALCAM. We also identified several miR-214–mediated prometastatic functions directly promoted by ALCAM. Silencing ALCAM in miR-214–overexpressing melanoma cells reduced cell migration and invasion without affecting growth or anoikisin vitro, and it also impaired extravasation and metastasis formation in vivo. Conversely, cell migration and extravasation was reduced in miR-214–overexpressing cells by upregulation of either miR 148b or TFAP2. These findings were consistent with patterns of expression of miR-214, ALCAM, and miR-148b in human melanoma specimens. Overall, our results define a pathway involving miR-214, miR-148b, TFAP2, and ALCAM that is critical for establishing distant metastases in melanoma

Learning from the italian experience during covid-19 pandemic waves: Be prepared and mind some crucial aspects

COVID-19 pandemic has rapidly spread worldwide causing a serious challenge to the global medical community. Italy was struck hard during the first wave earlier this year and several weaknesses as well as general unpreparedness of the national healthcare system were acknowledged. Learning essential lessons from the past, we realized how implementing contingency response measures, human resources and social dynamics could have changed the outcome if promptly adopted. This review translates the previous experience into strategic actions that has to be considered when developing appropriate national and regional operational plans to respond to a pandemic