Development of a molecular method for the rapid screening and identification of the three functionally relevant polymorphisms in the human TAS2R38 receptor gene in studies of sensitivity to the bitter taste of PROP

The objective of this work was to develop a rapid screening method to identify the three single nucleotide polymorphisms (SNPs) in the TAS2R38 gene, with the aim of providing a significant contribution to studies designed to assess sensitivity to the bitter taste of 6-n-propylthiouracil (PROP). Specifically, the objective of this study was to characterize the TAS2R38 gene haplotypes in a group of 60 subjects with variable sensitivity to PROP and preliminarily genotyped for the rs2274333 allele (A/G) of carbonic anhydrase isoform VI gene (CA6). The molecular characterization of the TAS2R38 gene was conducted using the PCR-restriction fragment length polymorphism technique after creating artificial restriction sites upstream or downstream of the SNPs, as none of the three polymorphisms contributes to the formation of a restriction site for a specific endonuclease. The results indicate that the method described in this paper could be a valid and simple experimental strategy to identify genetic differences related to taste sensitivity to bitter taste, and could be applied as a nutrigenetics test in studies aimed at understanding people’s eating behaviors

The Transcivilisational Perspective and the Universalism of the International Criminal Court

The International Criminal Court (ICC) seems to have finally realized the ending legal globalists have long yearned for: a potentially universal, centralized and permanent court, able to enforce international humanitarian law without the mediation of the state. A legal system of mankind seems now more possible than ever before. The universalistic claim of the ICC, I contend in this article, is nevertheless potentially biased by a West-centric prejudice. Critically drawing on the transcivilizational perspective suggested by Onuma Yasuaki, I propose to overcome the West-centric approach of the ICC by assuming the multiplicity of universalisms, thus relativising each of them

Effects and Effectiveness of Surveillance Technologies: Mapping Perceptions, Reducing Harm

This paper addresses issues regarding perceptions of surveillance technologies in Europe. It analyses existing studies in order to explore how perceptions of surveillance affect and are affected by the negative effects of surveillance and how perceptions and effectiveness of surveillance technologies relate to each other. The paper identifies 12 negative effects of surveillance including, among others, privacy intrusion, the chilling effect and social exclusion, and classifies them into three groups. It further illustrates the different ways in which perceptions and effectiveness of surveillance interact with each other, distinguishing between perceived security and perceived effectiveness. Finally, the paper advances a methodology to take into account perception issues when designing new surveillance technologies. By doing so, it rejects manipulative measures aiming at improving perceptions only and suggests measures that address the background conditions affecting perceptions

Privacy: scepticism, normative approaches and legal protection. A review of the theoretical debate and a discussion of recent developments in the EU

Digitalisation has lent the right to privacy increasing philosophical and legal relevance. However, privacy’s epistemic status and associated normative values are constantly subject to radical criticisms. This article investigates the validity, in theory and practice, of three radical critiques of privacy. A review of the philosophical and interdisciplinary discourse on privacy during the last half century is followed by analyses of recent legal developments within the EU. Privacy emerges as a highly differentiated and powerful tool to protect individuals and social relations and to limit and redistribute power. However, the right to privacy remains far from realising its practical potential

Towards a unified list of ethical principles for emerging technologies. An analysis of four European reports on molecular biotechnology and artificial intelligence

Artificial intelligence (AI) and molecular biotechnologies (MB) are among the most promising, but also ethically hotly debated emerging technologies. In both fields, several ethics reports, which invoke lists of ethics principles, have been put forward. These reports and the principles lists are technology specific. This article aims to contribute to the ongoing debate on ethics of emerging technologies by comparatively analysing four European ethics reports from the two technology fields. Adopting a qualitative and in-depth approach, the article highlights how ethics principles from MB can inform AI ethics and vice versa. By synthesizing the respective ethical cores of the principles included in the analysed reports, the article derives, moreover, a unified list of principles for assessing emerging technologies. The suggested list consists of nine principles: autonomy; individual and social well-being and prevention of harm; reliability, safety and security; informational privacy; transparency; accountability; communication, participation and democracy; justice, fairness, and non-discrimination; sustainability

Self-propagating high-temperature reactions: remarks and recent results

Solid-solid and gas-solid self-propagating high temperature reactions are exploited for interesting and relatively new technological applications based on the so called Self-propagating High-temperature Synthesis (SHS) technique This paper reviews the recent results obtained, also in the framework of national and international collaborations, by Cao and coworkers in the field of self-propagating high-temperature reactions with particular emphasis on SHS fundamentals and applications. In particular, the research activity conducted so far can be divided into three main topics: Macrokinetics studies on SHS using structural statics as well as dynamics approaches; Modeling studies on SHS, with the aim of developing analytical expressions of combustion front velocity and simulating experimental techniques applied for macrokinetics investigations; Technological applications related to the synthesis of centrifugal coatings and environmental protection. The activities outlined above will be described in this review paper in separate sections as discussed next