8 research outputs found
The Norm Estimates of Pre-Schwarzian Derivatives of Spirallike Functions and Uniformly Convex -spirallike Functions
For a constant , we definea subclass of the spirallike functions, , the setof all functions [releft{e^{-ialpha}frac{zf'(z)}{f(z)}right}geqleft|frac{zf'(z)}{f(z)}-1right|.]In the present paper, we shall give the estimate of the norm of the pre-Schwarzian derivative where for the functions in
Treatment of Hypertrophic Scar in Human with Autologous Transplantation of Cultured Keratinocytes and Fibroblasts along with Fibrin Glue
Objective: Hypertrophic scar involves excessive amounts of collagen in dermal layer and
may be painful. Nowadays, we can’t be sure about effectiveness of procedure for hypertrophic
scar management. The application of stem cells with natural scaffold has been the
best option for treatment of burn wounds and skin defect, in recent decades. Fibrin glue
(FG) was among the first of the natural biomaterials applied to enhance skin deformity in
burn patients. This study aimed to identify an efficient, minimally invasive and economical
transplantation procedure using novel FG from human cord blood for treatment of hypertrophic
scar and regulation collagen synthesis.
Materials and Methods: In this case series study, eight patients were selected with hypertrophic
scar due to full-thickness burns. Human keratinocytes and fibroblasts derived
from adult skin donors were isolated and cultured. They were tested for the expression of
cytokeratin 14 and vimentin using immunocytochemistry. FG was prepared from pooled
cord blood. Hypertrophic scars were extensively excised then grafted by simply placing
the sheet of FG containing autologous fibroblast and keratinocytes. Histological analyses
were performed using Hematoxylin and eosin (H&E) and Masson’s Trichrome (MT) staining
of the biopsies after 8 weeks.
Results: Cultured keratinocytes showed a high level of cytokeratin 14 expression and
also fibroblasts showed a high level of vimentin. Histological analyses of skin biopsies
after 8 weeks of transplantation revealed re-epithelialization with reduction of hypertrophic
scars in 2 patients.
Conclusion: These results suggest may be the use of FG from cord blood, which is not
more efficient than previous biological transporters and increasing hypertrophic scar
relapse, but could lead to decrease pain rate
Long-Term Follow-up of Autologous Fibroblast Transplantation for Facial Contour Deformities, A Non-Randomized Phase IIa Clinical Trial
Objective: Recently, the promising potential of fibroblast transplantation has become a novel modality for skin
rejuvenation. We investigated the long-term safety and efficacy of autologous fibroblast transplantation for participants
with mild to severe facial contour deformities.
Materials and Methods: In this open-label, single-arm phase IIa clinical trial, a total of 57 participants with wrinkles
(n=37, 132 treatment sites) or acne scars (n=20, 36 treatment sites) who had an evaluator’s assessment score of
at least 2 out 7 (based on a standard photo-guide scoring) received 3 injections of autologous cultured fibroblasts
administered at 4-6 week intervals. Efficacy evaluations were performed at 2, 6, 12, and 24 months after the final
injection based on evaluator and patient’s assessment scores.
Results: Our study showed a mean improvement of 2 scores in the wrinkle and acne scar treatment sites. At sixth
months after transplantation, 90.1% of the wrinkle sites and 86.1% of the acne scar sites showed at least a one grade
improvement on evaluator assessments. We also observed at least a 2-grade improvement in 56.1% of the wrinkle
sites and 63.9% of the acne scar sites. A total of 70.5% of wrinkle sites and 72.2% of acne scar sites were scored as
good or excellent on patient assessments. The efficacy outcomes remained stable up to 24-month. We did not observe
any serious adverse events during the study.
Conclusion: These results have shown that autologous fibroblast transplantation could be a promising remodeling
modality with long-term corrective ability and minimal adverse events (Registration Number: NCT01115634)
On the Strong Starlikeness of the Bernardi Transform
Many papers concern both the starlikeness and the convexity of Bernardi integral operator. Using the Nunokawa’s Lemma, we want to determine conditions for the strong starlikeness of the Bernardi transform of normalized analytic functions g, such that |arg{g′(z)}| <απ2 in the open unit disk Δ where 0<α<2. Our results include the results of Mocanu, Nunokawa and others on the Libera transform
Neighborhood Properties for k-Uniformly Starlike Functions
In this note, we define the class Sp(; k) and introduce and investigatecoefficient estimates, neighborhood property for functions in theclass Sp(; k). In addition we provide conditions such that the confluenthypergeometric function, belongs to Sp(; k
On the Strong Starlikeness of the Bernardi Transform
Many papers concern both the starlikeness and the convexity of Bernardi integral operator. Using the Nunokawa’s Lemma, we want to determine conditions for the strong starlikeness of the Bernardi transform of normalized analytic functions g, such that |arg{g′(z)}| απ2 in the open unit disk Δ where 0α2. Our results include the results of Mocanu, Nunokawa and others on the Libera transform
The Effect of Educational Intervention based on BASNEF Model on Decreasing the Cesarean Section Rate among Pregnant Women in Khomain County
Objective:Over the past two decades, the incidence of cesarean section in most countries has increased. Cesarean section increases the risk of death and complications in the mother and fetus. Educational interventions based on behavior change models can play an important role in reduce the rate of cesarean section. The aim of our study is investigation the effect of educational intervention based on BASNEF Model on decreasing of cesarean section rate among pregnant women in Khomain County, from June to November 2013.
Materials and methods:In this interventional study, 140 nulliparous women who were in their last trimester of pregnancy were randomly allocated to case and control groups. Data gathering instrument was a questionnaire based on BASNEF framework. Data were analyzed by SPSS14 software.
Results:The scores of knowledge, attitudes, subjective norms, and enabling factors in the intervention group than the control group showed a significant difference (p <0.001). After the study, it was found that 18 women (25.7%) in case group and 42 women (60%) in the control group underwent cesarean section. By Chi-square test showed that the difference in the type of delivery between the two groups was statistically significant (p<0.001).
Conclusion:Design and implement curriculum based on BASNEF can be effective in reducing elective cesarean section