709 research outputs found

    Covering Kids & Families Evaluation: Public Coverage Versus No Coverage for Children: Perceptions and Experiences of Parents in Four Cities

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    Based on interviews, examines the perceptions and experiences that shape parents' decisions on enrolling their children in Medicaid and State Children's Health Insurance Programs. Considers remaining challenges, including language barriers

    Present state of knowledge of the upper atmosphere 1990: An assessment report

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    NASA is charged with the responsibility to report on the state of the knowledge of the Earth's upper atmosphere, particularly the stratosphere. Part 1 of this report, issued earlier this year, summarized the objectives, status, and accomplishments of the research tasks supported under NASA's Upper Atmosphere Research Program during the last two years. New findings since the last report to Congress was issued in 1988 are presented. Several scientific assessments of the current understanding of the chemical composition and physical structure of the stratosphere are included, in particular how the abundance and distribution of ozone is predicted to change in the future. These reviews include: a summary of the most recent international assessment of stratospheric ozone; a study of future chlorine and bromine loading of the atmosphere; a review of the photochemical and chemical kinetics data that are used as input parameters for the atmospheric models; a new assessment of the impact of Space Shuttle launches on the stratosphere; a summary of the environmental issues and needed research to evaluate the impact of the newly re-proposed fleet of stratospheric supersonic civil aircraft; and a list of the contributors to this report and the science assessments which have formed our present state of knowledge of the upper atmosphere and ozone depletion

    Three-Dimensional Structure of Conotoxin tx3a: A m-1 Branch Peptide of the M-Superfamily

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    The M-superfamily, one of eight major conotoxin superfamilies found in the venom of the cone snail, contains a Cys framework with disulfide-linked loops labeled 1, 2, and 3 (- CC1C2C3CC-). M-superfamily conotoxins can be divided into the m-1, -2, -3 and -4 branches, based upon the number of residues located in the third Cys loop between the fourth and fifth Cys residues. Here we provide a three-dimensional solution structure for the m-1 conotoxin tx3a found in the venom of Conus textile. The 15 amino acid peptide, CCSWDVCDHPSCTCC, has disulfide bonds between Cys1 and Cys14, Cys2 and Cys12, and Cys7 and Cys15 typical of the C1- C5, C2-C4, and C3-C6 connectivity pattern seen in m-1 branch peptides. The tertiary structure of tx3a was determined by 2D 1H NMR in combination with the combined assignment and dynamics algorithm for nuclear magnetic resonance (NMR) applications CYANA program. Input for structure calculations consisted of 62 inter- and intraproton, 5 phi angle, and 4 hydrogen bond constraints. The root-mean-square deviation values for the 20 final structures are 0.32 +/- 0.07 Å and 0.84 +/- 0.11 Å for the backbone and heavy atoms, respectively. Surprisingly, the structure of tx3a has a “triple-turn” motif seen in the m-2 branch conotoxin mr3a, which is absent in mr3e, the only other member of the m-1 branch of the M-superfamily whose structure is known. Interestingly, injection of tx3a into mice elicits an excitatory response similar to that of the m-2 branch peptide mr3a, even though the conotoxins have different disulfide connectivity patterns

    Health and Quality of Life among People with Intellectual and Developmental Disabilities and Direct Support Professionals during the early United States COVID-19 Pandemic

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    People with intellectual and developmental disabilities (IDD) and the direct support professionals (DSPs) who support them have faced unique risks to their health and quality of life (QoL) throughout the COVID-19 pandemic. We sought to understand how COVID-19 has influenced QoL and overall well-being among these populations. We conducted a Rapid Qualitative Inquiry study with a sample of people with IDD and DSPs (n = 18) to gain deeper perspectives about QoL and well-being during the pandemic. Participants described that changes in QoL were typically negative and influenced primarily by reduced socialization and impacts on health and independence; however, participants also described the ways their interactions and mutual support for each other helped to preserve some aspects of QoL. Participants described how racism and publicized acts of racial violence contributed to their COVID-19 experiences, and offered descriptions of resources they benefited from, and those they lacked, during this time. Study findings have the potential to inform the development of policies and best practices that support people with IDD and DSPs during and following similar infectious disease emergencies

    Experiments with a Malkus-Lorenz water wheel: Chaos and Synchronization

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    We describe a simple experimental implementation of the Malkus-Lorenz water wheel. We demonstrate that both chaotic and periodic behavior is found as wheel parameters are changed in agreement with predictions from the Lorenz model. We furthermore show that when the measured angular velocity of our water wheel is used as an input signal to a computer model implementing the Lorenz equations, high quality chaos synchronization of the model and the water wheel is achieved. This indicates that the Lorenz equations provide a good description of the water wheel dynamics.Comment: 12 pages, 7 figures. The following article has been accepted by the American Journal of Physics. After it is published, it will be found at http://scitation.aip.org/ajp

    Identification and implementation of potential energy efficiency programs in Indian Country: Working paper series--04-03

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    The strongest recommendation stemming from the Air Pollution Prevention forum of the Western Regional Air Partnership (WRAP) was for tribes to develop and implement energy plans. This paper provides a discussion of the benefits of any such plan and itemized a variety of components of any said plan. A brief discussion of the WRAP is presented is the framework of improving air quality. Based on the background of Jacobs (2000) and Smith (2000), the primary and secondary benefits of energy efficiency plans are then discussed. Then a series of specific recommendations are itemized. These include tribally sponsored programs, collaborative opportunities, and tribal leadership programs
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