The East German Wage Structure after Transition

We extend the literature on transition economies' wage structures by investigating the returns to tenure and experience. This study applies recent panel data and estimation approaches that control for hitherto neglected biases. We compare the life cycle structure of East and West German wages for fulltime employed men in the private sector. The patterns in the returns to seniority are similar for the two regional labor markets. The returns to experience lag behind in the East German labor market, even almost 20 years after unification with significant differences particularly for high skill workers. The results are robust when only individuals are considered who started their labor market career in the market economy. We expect that the different returns are related to the heterogeneity of work experience gathered in East versus West Germany.wage structure, life cycle earnings, returns to tenure, returns to experience

The East German Wage Structure after Transition

We extend the literature on transition economies' wage structures by investigating the returns to tenure and experience. This study applies recent panel data and estimation approaches that control for hitherto neglected biases. We compare the life cycle structure in East and West German wages for fulltime employed men in the private sector. The patterns in the returns to seniority are similar for the two regional labor markets. The returns to experience lag behind in the East German labor market, even almost 20 years after unification. The results are robust when only individuals are considered who started their labor market career in the market economy and they hold across skill groups.wage structure, life cycle earnings, returns to tenure, returns to experience

The East German Wage Structure after Transition

We extend the literature on transition economies' wage structures by investigating the returns to tenure and experience. This study applies recent panel data and estimation approaches that control for hitherto neglected biases. We compare the life cycle structure in East and West German wages for fulltime employed men in the private sector. The patterns in the returns to seniority are similar for the two regional labor markets. The returns to experience lag behind in the East German labor market, even almost 20 years after unification. The results are robust when only individuals are considered who started their labor market career in the market economy and they hold across skill groups.wage structure, life cycle earnings, returns to tenure, returns to experience

The East German Wage Structure after Transition

We extend the literature on transition economies' wage structures by investigating the returns to tenure and experience. This study applies recent panel data and estimation approaches that control for hitherto neglected biases. We compare the life cycle structure in East and West German wages for fulltime employed men in the private sector. The patterns in the returns to seniority are similar for the two regional labor markets. The returns to experience lag behind in the East German labor market, even almost 20 years after unification. The results are robust when only individuals are considered who started their labor market career in the market economy and they hold across skill groups.wage structure, life cycle earnings, returns to tenure, returns to experience

Im Osten nichts Neues – Lohnstrukturen knapp 20 Jahre nach dem Mauerfall

Die Frage nach dem Zeitbedarf für die Anpassung der Lohnstrukturen eines ehemaligen sozialistischen Landes an das Niveau eines marktwirtschaftlichen Systems ist von hohem politischen Interesse. In der vorliegenden Studie werden die Lohnstrukturen in Ostdeutschland unter diesem Gesichtspunkt knapp 20 Jahre nach der Wiedervereinigung untersucht. Es zeigt sich, dass bis heute noch keine vollständige Anpassung erkennbar ist.Lohnstruktur; Anpassung; Neue Bundesländer

Lohnentwicklung im Lebenszyklus - Eine Analyse von Ausmaß, Begründung und Heterogenität von Lohnsteigerungen

This paper summarizes the findings of studies which investigate the determinants of wages in Germany, using data of the German Socioeconomic Panel (GSOEP). The empirical analyses apply least squares estimates as well as the estimators developed by Altonji and Shakotko (1987) and Topel (1991). These estimators reduce the endogeneity of indicators of specific and general labor market experience. The studies focus on the heterogeneity in wage determinants in the private and the public sector, in East and West Germany, for men and women, as well as in large versus small firms. Among the most interesting results, we find clear differences in returns to experience between East and West and by employer size.wage structure, human capital, tenure, experience

Safety of guselkumab in hepatitis B virus infection

Reactivation of hepatitis B virus (HBV) following the use of TNF antagonists has been reported and is a contraindication to use of these medications. Although the risk of reactivation of HBV during use of ustekinumab and secukinumab is low in patients with only HBV core antibody positivity, the risk is substantial in patients with chronic HBV infection. Less information is available regarding the use of pure IL-23 antagonists. Herein we discuss the successful treatment with guselkumab of a patient with HBV core antibody positivity, without evidence of HBV reactivation or other liver complications

Role of combination bortezomib and pegylated liposomal doxorubicin in the management of relapsed and/or refractory multiple myeloma

The first in class proteasome inhibitor bortezomib (B) received its initial regulatory approval for therapy of patients with multiple myeloma (MM) in the relapsed/refractory setting. Modulation of proteasome function, however, is also a rational strategy for chemosensitization, and a variety of agents have shown synergistic activity with bortezomib pre-clinically, including anthracyclines. This formed the basis for evaluation of a regimen of bortezomib with pegylated liposomal doxorubicin (PLD). PLD+B, in a phase I study, induced a predictable and manageable toxicity profile, and showed encouraging anti-MM activity. In a recent international, randomized phase III trial, PLD+B demonstrated a superior overall response rate and response quality compared to bortezomib alone, as well as a longer time to progression, duration of response, progression-free survival, and overall survival. Sub-analyses revealed benefits in almost all clinically relevant subgroups, including several which would be considered to have high-risk disease. These findings have led to the establishment of the PLD+B regimen as one of the standards of care for patients with relapsed and/or refractory myeloma. Efforts are now underway to build on this combination further by adding other active anti-myeloma agents. In this review, we will discuss the role of PLD+B as an important addition to our therapeutic armamentarium for patients with MM

NF-κB as a therapeutic target in cancer

The transcription factor nuclear factor (NF)-κB is activated in certain cancers and in response to chemotherapy and radiation. The transcriptional activation of genes associated with cell proliferation, angiogenesis, metastasis and suppression of apoptosis appears to lie at the heart of the ability of NF-κB to promote oncogenesis and cancer therapy resistance. Supporting these findings are recent experiments, performed in vitro and using xenograft models of cancer, which implicate NF-κB inhibition as an important new approach for the treatment of certain hematological malignancies and as an adjuvant approach in combination with chemotherapy or radiation for a variety of cancers. Clinical trials with drugs that block NF-κB are currently in progress with promising results. However, as there is currently no drug that blocks specific NF-κB activation, conclusions drawn with small-molecule inhibitors must be interpreted carefully