The behavior limestone under explosive load

Limestone behavior under explosive loading was investigated. The behavior of the limestone by the action of the three types of explosives, including granular, ammonite and emulsion explosives was studied in detail. The shape and diameter of the explosion craters were obtained. The observed fragments after the blast have been classified as large, medium and small fragments. Three full-scale experiments were carried out. The research results can be used as a qualitative test for the approbation of numerical methods

Research of the behavior of ice on water under explosive loads

Complex theoretical and experimental studies of the behavior of ice under dynamic loads are presented. New experimental data about blast of snow-covered ice have been obtained. A complete coincidence of the experimental data of 2013 and 2017 was found. Test calculations, including impact test have been carried out. Shock adiabatics of ice and water are presented. The behavior of the ice block on the water under explosion was investigated. The velocity of the free surface, the volume of ice destruction, the diameter of the explosive lane in ice cover were calculated. Recommendations for more effective ice destruction under these conditions were given

Effect of forced treadmill running on skeletal muscle myokine levels in mice with a model of type II diabetes mellitus

The effect of forced treadmill running on the level of some cytokines in skeletal muscles of mice with a model of type II diabetes mellitus was studied. The mouse model was developed using a 12-week high-fat diet; physical loading in the form of forced treadmill running was applied for 4 weeks. The concentration of myokines in m. gastrocnemius was determined by an enzyme-linked immunosorbent assay (ELISA). Diabetes formation in mice was accompanied by changes in the skeletal muscle concentration of two pro-inflammatory cytokines: an increase in IL-6 and a decrease in IL-15. Forced treadmill running loads had differential effects on the level of myokines in healthy and sick mice. In healthy animals, there was a decrease in IL-6 and IL-15 concentrations and an increase in the leukemia inhibitory factor (LIF) concentration in skeletal muscles after 4 weeks of regular forced running. At the same time, in diabetic mice, IL-6 and IL-15 concentrations increased, while the LIF concentration decreased after forced running loads. The NAP3 concentration in skeletal muscles was found to be insensitive to both the development of type II diabetes mellitus and regular forced treadmill running