Atrofia da medula espinhal na ataxia espinocerebelar do tipo 1

Universidade Federal de São Paulo (UNIFESP) Setor de Neurologia Geral e Ataxias Departamento de Neurologia e NeurocirurgiaUNIFESP, Setor de Neurologia Geral e Ataxias Depto. de Neurologia e NeurocirurgiaSciEL

As contribuicoes de Babinski para os sinais cerebelares: construindo as bases do exame neurologico

Several assumptions about the function of the cerebellum and semiotic signs have been described over the centuries. Among the long list of famous researchers who have provided a strong contribution and who have left their names on the highway of cerebellar research, Joseph Babinski appears as a prominent name. The description of various forms of cerebellar symptomatology was a major part of Babinski's work, and clinical terms that he introduced, namely hypermetry , diadochokinesia , and asynergy , remain part of contemporary clinical vocabulary. Babinski studied cerebellar signs in many patients and was able to conduct longitudinal studies that permitted him to understand the evolution of cerebellar dysfunction. Babinski contributions to cerebellar symptomatology continue to influence the most modern theories, including functional and neuropathological studies.Diversas teorias sobre a função do cerebelo e a semiologia dos sinais cerebelares têm sido descritas ao longo dos séculos. Dentre a longa lista de pesquisadores renomados que apresentaram importantes contribuições nesse assunto e que deixaram seus nomes na história, Joseph Babinski aparece com destaque. A descrição dos mais variados sintomas e sinais cerebelares foi peça importante do trabalho de Babinski e algumas nomenclaturas introduzidas por ele, tais como hipermetria , disdiadococinesia e assinergia , continuam a fazer parte do vocabulário contemporâneo. Babinski estudou os sinais cerebelares em muitos pacientes e foi capaz de realizar pesquisas que lhe permitiram compreender a disfunção cerebelar. As contribuições de Babinski para a caracterizar a sintomatologia cerebelar continuam a influenciar as teorias mais modernas, a despeito de estudos funcionais e neuropatológicos.Universidade Federal de São Paulo (UNIFESP) Setor de Neurologia Geral e Ataxias Departamento de Neurologia e NeurocirurgiaRush University Medical Center Department of Neurological SciencesUNIFESP, Setor de Neurologia Geral e Ataxias Depto. de Neurologia e NeurocirurgiaSciEL

Lentiform "Fork Sign" and Parkinsonism After Acute Myocardial Infarction and Cardiac Failure

Univ Fed Sao Paulo, Dept Neurol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Neurol, Sao Paulo, SP, BrazilWeb of Scienc

Facial grimacing como pista para o diagnóstico de gangliosidose GM1 tipo 3

Universidade Federal de São Paulo (UNIFESP) Departamento de Neurologia e Neurocirurgia Ambulatório de Neurologia GeralUNIFESP, Depto. de Neurologia e Neurocirurgia Ambulatório de Neurologia GeralSciEL

Brain SPECT imaging in Sydenham's chorea

The objective of the present study was to determine whether brain single-photon emission computed tomography (SPECT) imaging is capable of detecting perfusional abnormalities. Ten Sydenham's chorea (SC) patients, eight females and two males, 8 to 25 years of age (mean 13.4), with a clinical diagnosis of SC were submitted to brain SPECT imaging. We used HMPAO labeled with technetium-99m at a dose of 740 MBq. Six examinations revealed hyperperfusion of the basal ganglia, while the remaining four were normal. The six patients with abnormal results were females and their data were not correlated with severity of symptoms. Patients with abnormal brain SPECT had a more recent onset of symptoms (mean of 49 days) compared to those with normal SPECT (mean of 85 days) but this difference did not reach statistical significance. Brain SPECT can be a helpful method to determine abnormalities of the basal ganglia in SC patients but further studies on a larger number of patients are needed in order to detect the phase of the disease during which the examination is more sensitive.Universidade Federal de São Paulo (UNIFESP) Departamento de Neurologia Setor de Distúrbios do MovimentoUniversidade Federal de São Paulo (UNIFESP) Departamento de Diagnóstico por Imagem Setor de Medicina NuclearUNIFESP, Depto. de Neurologia Setor de Distúrbios do MovimentoUNIFESP, Depto. de Diagnóstico por Imagem Setor de Medicina NuclearSciEL

Sinal da cruz mimetizando atrofia de multiplos sistemas em um paciente com doenca de Machado-Joseph

Universidade Federal de São Paulo (UNIFESP) Department of Neurology Ataxia UnitUniversidade Federal de São Paulo (UNIFESP) Department of RadiologyDelboni Auriemo, Diagnosticos da AmericaUNIFESP, Department of Neurology Ataxia UnitUNIFESP, Department of RadiologySciEL

The relationship between Marcel Proust and Joseph Babinski: the encounter of two geniuses

Marcel Proust was one of the greatest French writers of all times. Since early in his life, Proust was interested in arts and particularly literature. He also demonstrated a great knowledge of medicine, particularly neurology. His father was a doctor, and contributed to neurology through studies on aphasia, stroke, hysteria, and neurasthenia. During his childhood, Proust had the first asthma attack, initially considered a manifestation of neurasthenia. Regarding his illness, Proust was in touch with several renowned neurologists, such as Brissaud, Babinski and Sollier, and other disciples of Charcot. Proust spent the last three years of his life mostly confined to his bedroom since his health had badly deteriorated. in one moment, Babinski was called, examined Proust and after leaving his bedroom, announced to his brother that Proust was practically dead. Few hours later, Proust developed vomica and died.Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)Universidade Federal de São Paulo, Dept Neurol, Setor Neurol Geral & Ataxias, São Paulo, BrazilUniv Fed Parana, Hosp Clin, Serv Neurol, Setor Disturbios Movimento, BR-80060000 Curitiba, Parana, BrazilUniv Fed Minas Gerais, Dept Interno Med, Serv Neurol, Setor Disturbios Movimento, Belo Horizonte, MG, BrazilUniversidade Federal de São Paulo, Dept Neurol, Setor Neurol Geral & Ataxias, São Paulo, BrazilWeb of Scienc