Rac Activation: P-Rex1 — A Convergence Point for PIP3 and Gβγ?

AbstractP-Rex1, a novel Rac activator, has been identified in the first biochemical purification of a guanine nucleotide exchange factor for GTPases of the Rho family. P-Rex1 is synergistically activated by PIP3 and Gβγ and may act as a coincidence detector for these signaling molecules

The Effects of Seated Position on Occupant Kinematics in Low-speed Rear-end Impacts

Copyright © 2005 SAE International Seventeen rear-end impacts with a nominal 8 km/hr change in velocity to five human subjects in four positions were conducted. The four seated positions consisted of the Normal position, with the torso against the seat back, looking straight ahead, hands on the steering wheel, and feet on the floor; the Torso Lean position, with the torso leaned forward approximately 10 degrees away from the seat back; the Head Flex position, with the head flexed forward approximately 20 degrees from normal; and the Head Flex / Torso Lean position, with the head flexed forward approximately 20 degrees from normal and the torso leaned forward approximately 10 degrees from normal position. Relative to the Normal position, it was found that in both positions involving the torso lean, the peak head acceleration for the subject’s head was reduced during the head-restraint impact. Further, the inertial acceleration of the head due to the forces on the neck, prior to the head rest impact, was somewhat higher for the two positions involving torso lean. Minor, transient, whiplash associated disorder (WAD) symptoms were noted. The nominal change in velocity used in this study appears to be of a reasonable magnitude to continue human subject out of position (OOP) testing

Longidorus israelensis sp. n. (Nematoda : Dorylaimoidea), a parasite of carrot in Israel

#Longidorus israelensis sp. n., espèce parthénogénétique associée à des dégâts sur carotte en Israël, est décrite. Cette espèce est caractérisée par une grande longueur du corps (7,1-9,1 mm), une région labiale légèrement en relief et aplatie frontalement, des poches amphidiennes non bilobées, un long odontostyle (125-135 micromètres) et une queue courte, sub-hémisphérique (36-46 micromètres). Elle présente également une disposition inhabituelle des noyaux des glandes oesophagiennes. Les carottes attaquées par #L. israelensis sp. n. voient la croissance de leurs racines stoppée, le départ de racines secondaires et l'apparition de renflements à l'extrémité des racines. Il en résulte des carottes déformées et divisées en pluseiurs parties. Le nématode est généralement rencontré à des profondeurs du sol variant de 20 à 40 cm mais il peut migrer jusqu'à 40-100 cm de profondeur de façon à survivre pendant la période estivale chaude et sèche. (Résumé d'auteur

Monte Carlo simulation method for Laughlin-like states in a disk geometry

We discuss an alternative accurate Monte Carlo method to calculate the ground-state energy and related quantities for Laughlin states of the fractional quantum Hall effect in a disk geometry. This alternative approach allows us to obtain accurate bulk regime (thermodynamic limit) values for various quantities from Monte Carlo simulations with a small number of particles (much smaller than that needed with standard Monte Carlo approaches).Comment: 13 pages, 6 figures, 2 table