Effects of Topically Administered Neuroprotective Drugs in Early Stages of Diabetic Retinopathy:Results of the EUROCONDOR Clinical Trial

The primary objective of this study was to assess whether the topical administration of two neuroprotective drugs (brimonidine and somatostatin) could prevent or arrest retinal neurodysfunction in patients with type 2 diabetes. For this purpose, adults aged between 45 and 75 years with a diabetes duration ≥5 years and an Early Treatment of Diabetic Retinopathy Study (ETDRS) level of ≤35 were randomly assigned to one of three arms: placebo, somatostatin, or brimonidine. The primary outcome was the change in implicit time (IT) assessed by multifocal electroretinography between baseline and at the end of follow-up (96 weeks). There were 449 eligible patients allocated to brimonidine (n = 152), somatostatin (n = 145), or placebo (n = 152). When the primary end point was evaluated in the whole population, we did not find any neuroprotective effect of brimonidine or somatostatin. However, in the subset of patients (34.7%) with preexisting retinal neurodysfunction, IT worsened in the placebo group (P < 0.001) but remained unchanged in the brimonidine and somatostatin groups. In conclusion, the topical administration of the selected neuroprotective agents appears useful in preventing the worsening of preexisting retinal neurodysfunction. This finding points to screening retinal neurodysfunction as a critical issue to identify a subset of patients in whom neuroprotective treatment might be of benefit

Musique pour Noël / Richard Purvis, aux Grandes Orgues de la "Grace Cathédrale" de San-Francisco

Titre uniforme : [Es ist ein Ros entsprungen. Op. 122, no 8]Comprend : ADESTE FIDELES : folklore - LO, HOW A ROSE / Praetorius, Brahms - IT CAME UPON A MIDNIGHT CLEAR / Willis - IN DULCI JUBILO / Dupré - JOY TO THE WORLD : folklore - O, LITTLE TOWN OF BETHLEEM / Redner, arrang. Purvis - O LITTLE TOWN OF BETHLEEM / Rednerversion originale - CORTEGE ET LITANIE / Dupré - CHRISTMAS CRADLE SONG / R. Purvis - THE FIRST NOEL : folklore - CAROL RHAPSODY : (Pot-pourri) : (Silent night, Hark, The Herald, Angels Sing, Adeste Fideles)BnF-Partenariats, Collection sonore - BelieveContient une table des matière

LOUANGE ET PRIERE / la Maîtrise de l'Oratoire ; dir. H. HORNUNG ; M.L. GIROD : à l'Orgue

Comprend : CANTIQUE 319 - PSAUME 42 - PSAUME 25 - CANTIQUE 372 - CANTIQUE 370 - PSAUME 97BnF-Partenariats, Collection sonore - BelieveContient une table des matière

Blue Hodge / Johny Hodges, saxo alto ; Wild Bill Davis, org. ; Les Spann, fl., guit. ; Sam Jones, cb ; Louis Hayes, batt.

Comprend : And then some - I wonder why - Azure te - Blue Hodge - Hodge podge - It shouldn't happen to a dream - Why are you blue - Knuckles - Stand by blues - There is no greater loveBnF-Partenariats, Collection sonore - BelieveContient une table des matière

MOONDUST : DOUZE SLOWS POUR LA DANSE / Bill DOGGETT, à l'orgue, et un Ensemble

Titre uniforme : [The nearness of you]Titre uniforme : [Gone with the wind]Comprend : MOONDUST / Bill DOGGETT - EVENTIDE / Bill DOGGETT - THERE'S NO YOU / DURG OM - ADAIR - HOPPER - THE NEARNESS OF YOU / CARMICHAEL - WASHINGTON - I'LL BE AROUND / Alec WILDER - TARA'S THEME / Max STEINER - STREET SCENE / Alfred NEWMAN - YOU DON'T KNOW WHAT LOVE IS / RAYE - De PAUL - MY REASON / DOGGETT - SHEPERD - MY REVERIE / Larry CLINTON - SWEET SLUMBER / MILLINDER - WOODE - NEIBURG - IT'S A DREAM / Bill DOGGETTBnF-Partenariats, Collection sonore - BelieveContient une table des matière

SURBOUM ! / les orchestres de : Trio Hill BILLY'S ; Nöel CHIBOUST ; William BOUCAYA ; Jean LECCIA ; Jacques BRIENNE ; Roger BOURDIN ; Maxim SAURY ; Virginie MORGAN ; Robert VALENTINO

Titre uniforme : [Beer barrel polka]Titre uniforme : [Ay, ay, ay]Titre uniforme : [Way down yonder in New Orleans]Comprend : BEER BARREL POLKA - CHACHACHA MADEMOISELLE - CONFUCIUS - MERCI MON DIEU - LE TANGO IMMOBILE - AY AY AY - WAY DOWN YONDER IN NEW ORLEANS - EN 1926 - J'AIME VALSER DANS TES BRAS - PRES : WIGGINS - OU IRONS-NOUS DIMANCHE PROCHAIN - DARDANELLABnF-Partenariats, Collection sonore - BelieveContient une table des matière