Atopic dermatitis and vitamin D: facts and controversies

Patients with atopic dermatitis have genetically determined risk factors that affect the barrier function of the skin and immune responses that interact with environmental factors. Clinically, this results in an intensely pruriginous and inflamed skin that allows the penetration of irritants and allergens and predisposes patients to colonization and infection by microorganisms. Among the various etiological factors responsible for the increased prevalence of atopic diseases over the past few decades, the role of vitamin D has been emphasized. As the pathogenesis of AD involves a complex interplay of epidermal barrier dysfunction and dysregulated immune response, and vitamin D is involved in both processes, it is reasonable to expect that vitamin D's status could be associated with atopic dermatitis' risk or severity. Such association is suggested by epidemiological and experimental data. in this review, we will discuss the evidence for and against this controversial relationship, emphasizing the possible etiopathogenic mechanisms involved.Univ Brasilia UNB, Brasilia, DF, BrazilFed Dist Hlth State Dept SES DF, Brasilia, DF, BrazilUniv Brasilia HUB UNB, Brasilia Univ Hosp, Brasilia, DF, BrazilSão Paulo Fed Univ UNIFESP, Brasilia, DF, BrazilSão Paulo Fed Univ UNIFESP, Brasilia, DF, BrazilWeb of Scienc

Voting in the Eurovision Song Contest

The Eurovision Song Contest is not only the largest song contest worldwide but also probably the world’s largest election for a non-political office. In this article, we are interested in the voting behaviour of Eurovision viewers. Do they vote sincerely, strategically according to rational choice assumptions (i.e. for the song they believe will be the likely winner) or for another song? Using data from a large-scale survey carried out in Europe, we find interesting voting patterns with regard to these questions. Roughly one-fourth of the survey participants would vote for either their preferred song or for the song they think will win. However, the percentage of strategic voters is lower (11%). In contrast, many individuals (i.e. 36% of participants) would vote for another song, one that is neither their preferred song, the likely winner, nor a rational choice. The reasoning behind these remaining votes may include neighbourhood voting, ethnic voting, and voting for one’s favourite European country