Modelo de gestión financiera para la optimización de los recursos económicos y financieros de la Cooperativa de Ahorro y Crédito “Puerto Francisco de Orellana Ltda.”, de la ciudad del Coca, provincia de Orellana, periodo 2015

En el presente proyecto se plantea un Modelo de Gestión Financiera para la optimización de los recursos económicos y financieros de la Cooperativa de Ahorro y Crédito “Puerto Francisco de Orellana Ltda.”, de la Ciudad del Coca, provincia de Orellana, periodo 2015, fue elaborado con la finalidad de lograr un manejo eficiente y eficaz de las actividades administrativas y financieras de la misma que tiene como principal actividad la captación y prestación de servicios económicos financieros, es de gran importancia porque está relacionado con la toma de decisiones, en donde se debe tener claro los objetivos que se pretenden alcanzar ya que nos facilita la toma de decisiones financieras para mantener la eficiencia operacional y la confiabilidad de la información, para la siguiente investigación se ha analizado los aspectos generales sobre la cual opera la cooperativa y en función de la realidad de la misma se ha involucrado herramientas, criterios y técnicas financieras actualizadas, para determinar un marco de acción que le permita analizar escenarios y alternativas de desempeño financiero de manera eficiente, y que le permita tomar las decisiones más correctas y oportunas para la cooperativa considerando la base legal, reseña histórica, organización interna.In this project a Financial Management Model for the optimization of the economic and financial resources of the credit union “Puerto Francisco de Orellana Ltd.!”, in Coca, Orellana Province, during 2015, was developed in order to achieve efficient and effective management of administrative and financial activities of the same, which is principally engaged in the acquisition and delivery of financial economic services, It is of great importance because it is related to decision-making, where it should be clear objectives to be achieved as well as making financial decisions is provided to maintain operational efficiency and reliability of the information to research the general aspects on which the operates and based on the reality of it have been involved tools, criteria, financial techniques to date, to determine a framework that allows analyzing scenarios and alternative performance was analyzed financial efficient financial way to maintain operational efficiency and reliability of the information, to allow making more accurate correct and timely decisions for the cooperative, considering the legal basis, historical review and internal organization

Bringing critical systems thinking to high school students through ocean acidification research

Ocean acidification is a complex phenomenon with complex consequences. Understanding this complexity and the impact of ocean acidification requires systems thinking and collaboration, both in research and in education. Scientific advancement will help us better understand the problem and devise more effective solutions, but executing these solutions will require widespread public participation to mitigate this local and global problem. We have translated current systems-level ocean acidification research into a 5 week high school curriculum module. We will present this curriculum which is easily implemented in schools and has resulted in a high level of engagement and learning. Thus far 13 different schools and over 1200 students have field tested this work – we have seen dramatic increases in students’ abilities to use inquiry and to challenge their mental models. The lessons are hands-on, interdisciplinary, standards-based, and specifically focus on systems thinking, which has been shown to enable behavioral change. In this curriculum, students take on the roles of scientists and delegates as they investigate the consequences of the changing carbon cycle on the chemistry and biology of the oceans. Students critically assess different pieces of information (news articles and real-time data from the Salish Sea and beyond). They combine their findings into a network diagram that interconnects key players of this system. Students align themselves with stakeholders and design collaborative, cohesive experiments to test hypotheses and network properties. They explore the consequences of increased CO2 levels on the pH of water, the integrity of seashells, and the lifecycle of diatoms. The module also connects to other pertinent lessons being developed locally and globally. In the culminating activity, students act as delegates and reconvene to discuss the systems consequences of ocean acidification. They make recommendations for further research, policy-making, and lifestyle changes on both a local and global scale

A Small Non-Coding RNA Modulates Expression of Pilus-1 Type in Streptococcus pneumoniae

Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide, and about 30% of the pneumococcal clinical isolates show type I pili-like structures. These long proteinaceous polymers extending from the bacterial surface are encoded by pilus islet 1 and play major roles in adhesion and host colonization. Pili expression is bistable and is controlled by the transcriptional activator RlrA. In this work, we demonstrate that the previously identified small noncoding RNA srn135 also participates in pilus regulation. Our findings show that srn135 is generated upon processing of the 5'-UTR region of rrgA messenger and its deletion prevents the synthesis of RrgA, the main pili adhesin. Moreover, overexpression of srn135 increases the expression of all pili genes and rises the percentage of piliated bacteria within a clonal population. This regulation is mediated by the stabilization of rlrA mRNA since higher levels of srn135 increase its half-life to 165%. Our findings suggest that srn135 has a dual role in pilus expression acting both in cis- (on the RrgA levels) and in trans- (modulating the levels of RlrA) and contributes to the delicate balance between pili expressing and non-expressing bacteria.This research was funded by Fondo de Investigación Sanitaria (FIS), grant number PI11/00656, and Ministerio de Economía, Industria y Competitividad, grant number BIO2017-82951-R.” P.A. was the recipient of a contract funded by the FIS project PI11/00656 and A.G.-S. was the recipient of a contract funded by Instituto de Salud Carlos III (CA10/1103).S

Contrasting Heat Stress Response Patterns of Coral Holobionts Across the Red Sea Suggest Distinct Mechanisms of Thermal Tolerance

Corals from the northern Red Sea, in particular the Gulf of Aqaba (GoA), have exceptionally high bleaching thresholds approaching \u3e5℃ above their maximum monthly mean (MMM) temperatures. These elevated thresholds are thought to be due to historical selection, as corals passed through the warmer Southern Red Sea during recolonization from the Arabian Sea. To test this hypothesis, we determined thermal tolerance thresholds of GoA versus central Red Sea (CRS) Stylophora pistillata corals using multi-temperature acute thermal stress assays to determine thermal thresholds. Relative thermal thresholds of GoA and CRS corals were indeed similar and exceptionally high (~7℃ above MMM). However, absolute thermal thresholds of CRS corals were on average 3℃ above those of GoA corals. To explore the molecular underpinnings, we determined gene expression and microbiome response of the coral holobiont. Transcriptomic responses differed markedly, with a strong response to the thermal stress in GoA corals and their symbiotic algae versus a remarkably muted response in CRS colonies. Concomitant to this, coral and algal genes showed temperature-induced expression in GoA corals, while exhibiting fixed high expression (front-loading) in CRS corals. Bacterial community composition of GoA corals changed dramatically under heat stress, whereas CRS corals displayed stable assemblages. We interpret the response of GoA corals as that of a resilient population approaching a tipping point in contrast to a pattern of consistently elevated thermal resistance in CRS corals that cannot further attune. Such response differences suggest distinct thermal tolerance mechanisms that may affect the response of coral populations to ocean warming

Canagliflozin and Cardiovascular and Renal Outcomes in Type 2 Diabetes Mellitus and Chronic Kidney Disease in Primary and Secondary Cardiovascular Prevention Groups

Background: Canagliflozin reduces the risk of kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, but effects on specific cardiovascular outcomes are uncertain, as are effects in people without previous cardiovascular disease (primary prevention). Methods: In CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation), 4401 participants with type 2 diabetes mellitus and chronic kidney disease were randomly assigned to canagliflozin or placebo on a background of optimized standard of care. Results: Primary prevention participants (n=2181, 49.6%) were younger (61 versus 65 years), were more often female (37% versus 31%), and had shorter duration of diabetes mellitus (15 years versus 16 years) compared with secondary prevention participants (n=2220, 50.4%). Canagliflozin reduced the risk of major cardiovascular events overall (hazard ratio [HR], 0.80 [95% CI, 0.67-0.95]; P=0.01), with consistent reductions in both the primary (HR, 0.68 [95% CI, 0.49-0.94]) and secondary (HR, 0.85 [95% CI, 0.69-1.06]) prevention groups (P for interaction=0.25). Effects were also similar for the components of the composite including cardiovascular death (HR, 0.78 [95% CI, 0.61-1.00]), nonfatal myocardial infarction (HR, 0.81 [95% CI, 0.59-1.10]), and nonfatal stroke (HR, 0.80 [95% CI, 0.56-1.15]). The risk of the primary composite renal outcome and the composite of cardiovascular death or hospitalization for heart failure were also consistently reduced in both the primary and secondary prevention groups (P for interaction >0.5 for each outcome). Conclusions: Canagliflozin significantly reduced major cardiovascular events and kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, including in participants who did not have previous cardiovascular disease

The ARID1B spectrum in 143 patients: from nonsyndromic intellectual disability to Coffin–Siris syndrome

Purpose: Pathogenic variants in ARID1B are one of the most frequent causes of intellectual disability (ID) as determined by large-scale exome sequencing studies. Most studies published thus far describe clinically diagnosed Coffin–Siris patients (ARID1B-CSS) and it is unclear whether these data are representative for patients identified through sequencing of unbiased ID cohorts (ARID1B-ID). We therefore sought to determine genotypic and phenotypic differences between ARID1B-ID and ARID1B-CSS. In parallel, we investigated the effect of different methods of phenotype reporting. Methods: Clinicians entered clinical data in an extensive web-based survey. Results: 79 ARID1B-CSS and 64 ARID1B-ID patients were included. CSS-associated dysmorphic features, such as thick eyebrows, long eyelashes, thick alae nasi, long and/or broad philtrum, small nails and small or absent fifth distal phalanx and hypertrichosis, were observed significantly more often (p < 0.001) in ARID1B-CSS patients. No other significant differences were identified. Conclusion: There are only minor differences between ARID1B-ID and ARID1B-CSS patients. ARID1B-related disorders seem to consist of a spectrum, and patients should be managed similarly. We demonstrated that data collection methods without an explicit option to report the absence of a feature (such as most Human Phenotype Ontology-based methods) tended to underestimate gene-related features

Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

The IPDGC (The International Parkinson Disease Genomics Consortium) and EADB (Alzheimer Disease European DNA biobank) are listed correctly as an author to the article, however, they were incorrectly listed more than once