Influence of fructose on the mechanisms for ethanol-induced hypertriglyceridaemia

Twelve adult albino rabbits with an average weight of 1.42kg were purchased and divided equally into the normal saline, ethanol and ethanol+fructose-treated groups. The ethanol-treated group orally received 1.5g (40%) ethanol/kg body weight as single daily dose, while the ethanol +fructose-treated animals also received the same ethanol dose, but were given in addition, 0.25gfructose/kg body weight after about 10 min of the ethanol administration. The normal saline-treated rabbits were given the equivalent amount of normal saline in lieu of ethanol. The animals were exposed to these various treatments along with their usual feeding pattern for a regular period of 15 weeks. Results showed that the progressive increase (P0.05) but decreased (

Effect of Nigerian citrus (Citrus sinensis Osbeck) honey on ethanol metabolism

The effect of Nigerian citrus (Citrus sinensis Osbeck) honey on ethanol metabolism was tested using 45  consenting individuals in apparent good health and between the ages of 25 and 35 years. The subjects were moderate social drinkers matched in terms of body weight and build. The results obtained showed that on average, honey significantly (p < 0.05) increased the blood ethanol clearance rate by 68% and decreased the  intoxication period by 43%, but insignificantly (p > 0.05) reduced the degree of intoxication by 9%. Honey could be a promising anti-intoxicating agent, but its long-term biochemical evaluation, possibly as a complement in the management of alcohol intoxication, deserves further study

Effect of Processing Techniques on The Contents of Flatulence Factors and Emulsion Properties of Cowpea ( Vigna unguiculata )

The effect of some processing techniques (germination boiling and dehulling) on the soluble sugar contents and the emulsion property of processed flour were studied. Results show that germination significantly reduced the raffinose level from the third to the fifth day sprouting period (P<0.05). Boiling and dehulling also reduced the content of this flatus oligosaccharide (raffinose) but not to a significant proportion (P>0.05). The contents of other soluble sugars-galactose, glucose and sucrose were increased by germination (P<0.05) and boiling (P>0.05) but reduced by dehulling (P>0.05). Germination, dehulling and boiling lowered the emulsion stability property of cowpea flour. Even though, it is not conventional to either malt or dehull cowpea seeds before cooking, individuals should be advised to do so, in order to minimize the flatus potential and the accompanied discomfort associated with beans consumption. However, such processing techniques would not be appropriate for foods that need good emulsion. @JASEM

Changes in some haematological parameters in Nigeria children with Burkitt's lymphoma

In order to investigate the prevalence of anaemia and related haematological disorders, fifty-seven Nigerian children with Burkitt's Lymphoma, (BL) between the ages of 4-14 years were randomly selected from the paediatric Ward, Ahmadu Bello University Teaching Hospital, Zaria and Kaduna. Twenty-eight age-matched children in apparent good health were included as control subjects. Results show that BL patients had significant (

Hepatoprotective Potentials Of Hibiscus rosasinensis Petal anthocyanin Extracts Against Carbon tetrachloride-Induced Acute Liver Damage in Wistar Rats.

Carbon tetrachloride (CCl4) is haloalkane that possesses a hepatotoxic effect. Material and Methods: The impact of anthocyanin fractions obtained from Hibiscus rosasinensis petal on carbon tetrachloride (CCl4) induced acute liver damage in wistar rats was studied using a combination of alanine transferase (ALT) activity value and liver: body weight gain ratio as indices. Results: CCl4 treatment significantly increased both ALT value and the liver: body weight gain ratio at the 1% probability level when compared with the control values. Conclusion: Pre-treatment with the anthocyanin fractions reduced the levels of these markers and hence, the degree of liver damage, though with varying potentials. The lead precipitated, non slimy red fraction possessed the greatest protective property on the rat liver when compared with the other anthocyanin fractions so tested. Keywords: Anthocyanin, carbon tetrachloride, alanine transferase, Hibiscus rosasinensis, liver damage.Sudan Journal of Medical Sciences Vol. 3 (1) 2008: pp. 33-3

Effect of oral fructose administration on alchohol-induced increase in plasma urate

ABSTRACT: Oral fructose administration has been demonstrated to stimulate the oxidation of alcohol. However, its influence on alcohol-induced hyperuricemia is yet to be documented. This study therefore, reports the effect of fructose on alcohol- induced increase in plasma urate in adult albino rabbits. Twelve male adult albino rabbits, divided into A, B and C experimental groups were purchased from Yoha Farms, Warri, Delta State. Group A, the control animals (n=4) were given normal saline, while Group B animals (n=4) orally received 1.5 g (40%) ethanol/kg body weight as single daily dose for a routine period of fifteen weeks. Group C rabbits (n=4) were treated in a similar manner but 0.25 g fructose/kg body weight was usually given after about 10 min of administering the ethanol dose. The results obtained show that ethanol administration significantly increased (

Changes in blood pressure and plasma urate induced by the metabolism of alcohol in humans

Changes in blood pressure (BP) and plasma urate produced by the bio-transformation of a moderate dose (0.75ml(20%) ethanol/kg body weight) of alcohol were determined after 1h, 6h (oxidation phase) and 12h (post oxidation phase) of consuming the alcohol dose. Twenty healthy Nigerians (ten males and ten females) were randomly selected for the study after their informed consent. Statistical analyses of the results using ANOVA showed a significant decrease (

The TH1/TH2 balance in clinical course of burkitt's lymphoma

No Abstract.Global Journal of Pure and Applied Sciences Vol. 13 (3) 2007: pp.411-41