14,850 research outputs found

    Bulk Band Gap and Surface State Conduction Observed in Voltage-Tuned Crystals of the Topological Insulator Bi2_2Se3_3

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    We report a transport study of exfoliated few monolayer crystals of topological insulator Bi2_2Se3_3 in an electric field effect (EFE) geometry. By doping the bulk crystals with Ca, we are able to fabricate devices with sufficiently low bulk carrier density to change the sign of the Hall density with the gate voltage VgV_g. We find that the temperature TT and magnetic field dependent transport properties in the vicinity of this VgV_g can be explained by a bulk channel with activation gap of approximately 50 meV and a relatively high mobility metallic channel that dominates at low TT. The conductance (approximately 2 ×\times 7e2/he^2/h), weak anti-localization, and metallic resistance-temperature profile of the latter lead us to identify it with the protected surface state. The relative smallness of the observed gap implies limitations for EFE topological insulator devices at room temperature.Comment: 4 pages, 4 figures. In new version, panels have been removed from Figures 1, 2, and 4 to improve clarity. Additional data included in Figure 4. Introduction and discussion revised and expande

    Alcohol-Induced Histone Acetylation Reveals a Gene Network Involved in Alcohol Tolerance

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    Alfredo Ghezzi, Harish R. Krishnan, Linda Lew, Francisco J. Prado III, Darryl S. Ong, Nigel S. Atkinson, Section of Neurobiology and Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, United States of AmericaSustained or repeated exposure to sedating drugs, such as alcohol, triggers homeostatic adaptations in the brain that lead to the development of drug tolerance and dependence. These adaptations involve long-term changes in the transcription of drug-responsive genes as well as an epigenetic restructuring of chromosomal regions that is thought to signal and maintain the altered transcriptional state. Alcohol-induced epigenetic changes have been shown to be important in the long-term adaptation that leads to alcohol tolerance and dependence endophenotypes. A major constraint impeding progress is that alcohol produces a surfeit of changes in gene expression, most of which may not make any meaningful contribution to the ethanol response under study. Here we used a novel genomic epigenetic approach to find genes relevant for functional alcohol tolerance by exploiting the commonalities of two chemically distinct alcohols. In Drosophila melanogaster, ethanol and benzyl alcohol induce mutual cross-tolerance, indicating that they share a common mechanism for producing tolerance. We surveyed the genome-wide changes in histone acetylation that occur in response to these drugs. Each drug induces modifications in a large number of genes. The genes that respond similarly to either treatment, however, represent a subgroup enriched for genes important for the common tolerance response. Genes were functionally tested for behavioral tolerance to the sedative effects of ethanol and benzyl alcohol using mutant and inducible RNAi stocks. We identified a network of genes that are essential for the development of tolerance to sedation by alcohol.This work was supported by National Institute of Health grant R01 AA018037 to NSA (http://www.nih.gov/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.NeuroscienceWaggoner Center for Alcohol and Addiction ResearchEmail: [email protected] (AG)Email: [email protected] (NSA

    Kinetic Equation for a Plasma and Its Application to High-frequency Conductivity

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    Kinetic equation for inhomogenious nonisotropic plasma and application to high frequency conductivit

    Heat capacity anomaly at the quantum critical point of the Transverse Ising Magnet CoNb_2O_6

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    The transverse Ising magnet Hamiltonian describing the Ising chain in a transverse magnetic field is the archetypal example of a system that undergoes a transition at a quantum critical point (QCP). The columbite CoNb2_2O6_6 is the closest realization of the transverse Ising magnet found to date. At low temperatures, neutron diffraction has observed a set of discrete collective spin modes near the QCP. We ask if there are low-lying spin excitations distinct from these relatively high energy modes. Using the heat capacity, we show that a significant band of gapless spin excitations exists. At the QCP, their spin entropy rises to a prominent peak that accounts for 30%\% of the total spin degrees of freedom. In a narrow field interval below the QCP, the gapless excitations display a fermion-like, temperature-linear heat capacity below 1 K. These novel gapless modes are the main spin excitations participating in, and affected, by the quantum transition.Comment: 14 pages total, 8 figure

    Event generators for two charged and neutral pions production in proton-antiproton annihilation

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    In the technical reports of Panda, The Orsay hadronic physics group have proposed to measure the electromagnetic time-like form factors of the proton via the ppˉp \bar{p} annihilation into e+e−e^{+}e^{-} reaction. The physics interest of the two-body hadronics channels is also emphasized in order to complete a full physics program of our letter of intent. The event generators for the two-body hadronic reactions are investigated in this repor
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