254 research outputs found
Thermal signatures of Little-Parks effect in the heat capacity of mesoscopic superconducting rings
We present the first measurements of thermal signatures of the Little-Parks
effect using a highly sensitive nanocalorimeter. Small variations of the heat
capacity of 2.5 millions of non interacting micrometer-sized
superconducting rings threaded by a magnetic flux have been measured by
attojoule calorimetry. This non-invasive method allows the measurement of
thermodynamic properties -- and hence the probing of the energy levels -- of
nanosystems without perturbing them electrically. It is observed that is
strongly influenced by the fluxoid quantization (Little-Parks effect) near the
critical temperature . The jump of at the superconducting phase
transition is an oscillating function of with a period ,
the magnetic flux quantum, which is in agreement with the Ginzburg-Landau
theory of superconductivity.Comment: To be published in Physical Review B, Rapid Communication
Thermodynamics of small systems by nanocalorimetry: from physical to biological nano-objects
Membrane based nanocalorimeters have been developed for ac calorimetry
experiments. It has allowed highly sensitive measurements of heat capacity from
solid state physics to complex systems like polymers and proteins. In this
article we review what has been developed in ac calorimetry toward the
measurement of very small systems. Firstly, at low temperature ac calorimetry
using silicon membrane permits the measurement of superconducting sample having
geometry down to the nanometer scale. New phase transitions have been found in
these nanosystems illustrated by heat capacity jumps versus the applied
magnetic field. Secondly, a sensor based on ultra-thin polymer membrane will be
presented. It has been devoted to thermal measurements of nanomagnetic systems
at intermediate temperature (20K to 300K). Thirdly, three specific polyimide
membrane based sensors have been designed for room temperature measurements.
One is devoted to phase transitions detection in polymer, the second one to
protein folding/unfolding studies and the third one will be used for the study
of heat release in living cells. The possibility of measuring systems out of
equilibrium will be emphasized
CD36 plays an important role in the clearance of oxLDL and associated age-dependent sub-retinal deposits
Age-related macular degeneration (AMD) represents the major cause of vision loss in industrialized nations. Laminar deposits in Bruch's membrane (BM) are among the first prominent histopathologic features, along with drusen formation, and have been found to contain oxidized lipids. Increases in concentrations of oxidized LDL (oxLDL) in plasma are observed with age and high fat high (HFHC) cholesterol diet. CD36 is the principal receptor implicated in uptake of oxLDL, and is expressed in the retinal pigment epithelium (RPE). We determined if CD36 participates in oxLDL uptake in RPE and correspondingly in clearance of sub-retinal deposits. Uptake of oxLDL by RPE in vitro and in vivo was CD36-dependent. CD36 deficiency in mice resulted in age-associated accumulation of oxLDL and sub-retinal BM thickening, despite fed a regular diet. Conversely, treatment of HFHC-fed ApoE null mice with a CD36 agonist, EP80317 (300 μg/kg/day), markedly diminished thickening of BM, and partially preserved (in part) photoreceptor function. In conclusion, our data uncover a new role for CD36 in the clearance of oxidized lipids from BM and in the prevention of age-dependent sub-retinal laminar deposits
Single-shot qubit readout in circuit Quantum Electrodynamics
The future development of quantum information using superconducting circuits
requires Josephson qubits [1] with long coherence times combined to a
high-fidelity readout. Major progress in the control of coherence has recently
been achieved using circuit quantum electrodynamics (cQED) architectures [2,
3], where the qubit is embedded in a coplanar waveguide resonator (CPWR) which
both provides a well controlled electromagnetic environment and serves as qubit
readout. In particular a new qubit design, the transmon, yields reproducibly
long coherence times [4, 5]. However, a high-fidelity single-shot readout of
the transmon, highly desirable for running simple quantum algorithms or measur-
ing quantum correlations in multi-qubit experiments, is still lacking. In this
work, we demonstrate a new transmon circuit where the CPWR is turned into a
sample-and-hold detector, namely a Josephson Bifurcation Amplifer (JBA) [6, 7],
which allows both fast measurement and single-shot discrimination of the qubit
states. We report Rabi oscillations with a high visibility of 94% together with
dephasing and relaxation times longer than 0:5 \mu\s. By performing two
subsequent measurements, we also demonstrate that this new readout does not
induce extra qubit relaxation.Comment: 14 pages including 4 figures, preprint forma
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