Study of the effects of mergers and acquisitions in the banking.

Case study on 3 mergers and acquisitions in the banking industry in Singapore: DBS-POS Bank, UOB-OUB, and OCBC-Keppel TatLee. To analyze the effects of the mergers and acquisitions in the banking industry in Singapor

Optimisation of platelet concentrates therapy: Composition, localisation, and duration of action

Platelet concentrates (PC) generally refers to a group of products that are prepared from autologous blood intended to enhance healing activities. PC therapy is now very popular in treating musculoskeletal injuries; however, inconsistent clinical results urge the need to understand the working mechanism of PC. It is generally believed that the platelet-derived bioactive factors are the active constituents, and their bioavailability in the vicinity of the lesion sites determines the treatment efficacies. Therefore, the composition, localisation, and duration of the action of PC would be key determinants. In this review, we discuss how different preparations and delivery methods of PC would affect the treatment outcomes with respect to clinical evidence about PC therapy for osteoarthritis, tendinopathies, rotator cuff tears, anterior cruciate ligament injuries, and bone fractures. This review can be used as a quick guide for the use of PC therapy and provide insights for the further optimisation of the therapy in the near future

Knee wobbling during the single-leg-squat-and-hold test reflects dynamic knee instability in patients with anterior cruciate ligament injury

We propose using the single-leg squat-and-hold (SLSH) task with kinematic analysis to objectively measure dynamic knee stability after anterior cruciate ligament (ACL) injury. There are three objectives of this study: to compare the knee kinematics of ACL-deficient patients and healthy controls by capturing knee wobbling during the SLSH task, to detect kinematic changes after ACL reconstruction, and to correlate the kinematic variables with self-reported knee function. Twenty-five ACL-deficient participants and 18 healthy matched participants were recruited. The knee kinematics involving both the magnitudes and frequency of motion fluctuation was captured during SLSH by 3D motion analysis system (Vicon). Compared to the limbs of the control participants, the ACL involved limbs exhibited a greater range of flexion-extension (4.33±1.96 vs. 2.73±1.15; p=0.005) and varus-valgus (2.52±0.99 vs. 1.36±0.42; p<0.001). It also inhibited higher frequency of flexion-extension (4.87±2.55 vs. 2.68±1.23; p=0.003) and varus-valgus (3.83±2.59 vs. 1.42±0.55; p<0.001). The range of flexion-extension (4.50±2.24 vs. 2.90± 1.01; p=0.018), frequency of flexion-extension (4.58±2.53 vs. 3.05± 1.80; p=0.038) and varus-valgus (3.46±2.11 vs. 1.80± 1.23; p=0.022) was reduced after ACL reconstruction. Increased frequency of knee varus-valgus was correlated with lower IKDC score (r=-0.328; p=0.034). Knee wobbling was more prominent in ACL-deficient patients, which was associated with poor knee function. SLSH task with kinematic analysis appears to be a potential assessment method for monitoring dynamic knee stability after ACL injury.</p

Whole-genome reconstruction and mutational signatures in gastric cancer.

BACKGROUND: Gastric cancer is the second highest cause of global cancer mortality. To explore the complete repertoire of somatic alterations in gastric cancer, we combined massively parallel short read and DNA paired-end tag sequencing to present the first whole-genome analysis of two gastric adenocarcinomas, one with chromosomal instability and the other with microsatellite instability. RESULTS: Integrative analysis and de novo assemblies revealed the architecture of a wild-type KRAS amplification, a common driver event in gastric cancer. We discovered three distinct mutational signatures in gastric cancer--against a genome-wide backdrop of oxidative and microsatellite instability-related mutational signatures, we identified the first exome-specific mutational signature. Further characterization of the impact of these signatures by combining sequencing data from 40 complete gastric cancer exomes and targeted screening of an additional 94 independent gastric tumors uncovered ACVR2A, RPL22 and LMAN1 as recurrently mutated genes in microsatellite instability-positive gastric cancer and PAPPA as a recurrently mutated gene in TP53 wild-type gastric cancer. CONCLUSIONS: These results highlight how whole-genome cancer sequencing can uncover information relevant to tissue-specific carcinogenesis that would otherwise be missed from exome-sequencing data

Survival Curve, Low Falls, Male vs Female.

<p>Survival Curve, Low Falls, Male vs Female.</p

Survival Curve, Male, Low Fall vs High Falls.

<p>Survival Curve, Male, Low Fall vs High Falls.</p

Guidelines for Conversion of Patient Histories to Heights in Metres.

<p>Guidelines for Conversion of Patient Histories to Heights in Metres.</p

The Low Fall as a Surrogate Marker of Frailty Predicts Long-Term Mortality in Older Trauma Patients - Table 2

<p>*Data provided as N (%) unless otherwise noted. SD: standard deviation</p><p>Characteristics of National Trauma Registry Patients aged over 45 (n = 8111).</p