Constitutive modelling of Sandvik 1RK91

A physically based constitutive equation is being developed for the maraging\ud stainless steel Sandvik 1RK91. The steel is used to make precision parts. These parts are formed through multistage forming operations and heat treatments from cold rolled and annealed sheets. The specific alloy is designed to be thermodynamically unstable, so that deformation even at room temperatures can bring about a change in the phase of face centred cubic austenite to either hexagonal closed packed martensite and/or, body centred cubic martensite. This solid state phase change is a function of the strain path, strain, strain rate and temperature. Thus, the fraction of the new phase formed depends on the state of stress at a given location in the part being formed. Therefore a set of experiments is being conducted in order to quantify the stress-strain behavior of this steel under various stress states, strain, strain rate as well as temperature. A magnetic sensor records the fraction of ferromagnetic martensite formed from paramagnetic austenite. A thermocouple as well as an infra red thermometer is used to log the change in temperature of the steel during a mechanical test. The force-displacement data are converted to stress-strain data after correcting for the changes in strain rate and temperature. These data are then cast into a general form of constitutive equation and the transformation equations are derived from Olson-Cohen type functions

Heterogeneity and bipotency of astroglial-like cerebellar progenitors along the interneuron and glial lineages

Cerebellar GABAergic interneurons in mouse comprise multiple subsets of morphologically and neurochemically distinct phenotypes located at strategic nodes of cerebellar local circuits. These cells are produced by common progenitors deriving from the ventricular epithelium during embryogenesis and from the prospective white matter (PWM) during postnatal development. However, it is not clear whether these progenitors are also shared by other cerebellar lineages and whether germinative sites different from the PWM originate inhibitory interneurons. Indeed, the postnatal cerebellum hosts another germinal site along the Purkinje cell layer (PCL), in which Bergmann glia are generated up to first the postnatal weeks, which was proposed to be neurogenic. Both PCL and PWM comprise precursors displaying traits of juvenile astroglia and neural stem cell markers. First, we examine the proliferative and fate potential of these niches, showing that different proliferative dynamics regulate progenitor amplification at these sites. In addition, PCL and PWM differ in the generated progeny. GABAergic interneurons are produced exclusively by PWM astroglial-like progenitors, whereas PCL precursors produce only astrocytes. Finally, through in vitro, ex vivo, and in vivo clonal analyses we provide evidence that the postnatal PWM hosts a bipotent progenitor that gives rise to both interneurons and white matter astrocytes

Inter-Rater Agreement and Validity of a Tackling Performance Assessment Scale in Youth American Football

Background: Long term neurologic injury and concussion have been identified as risks from participation in American football. Altering tackling form has been recommended to reduce the risk of neurologic injury caused by head accelerations when tackling. The purpose of this research is to determine the inter-rater agreement and validity of the Qualitative Youth Tackling System (QYTS), a six-item feedback scale to correct tackling form, when utilized by novice and expert raters. Hypothesis: Experienced raters will have higher levels of agreement with each other and with motion capture when compared to novice raters. Methods: Both novice and experienced raters viewed video of youth athletes (ages 9-13) tackling a dummy in a laboratory setting along. The raters identified successful performance according to a binary rating scale for each component. Analysis of both the raters\u27 agreement with each other and with an objective motion capture measure were completed. Results: Fliess\u27 Kappa measures between all raters were found to be moderate for head placement (k=.48), fair for cervical extension (k=.38), trunk inclination (k=.37), shoulder extension (k=.27) and step length (k=.29), and there was no agreement for pelvic height (k=.-16). When compared to the dichotomized validation measures of each of the five components provided by the motion capture system the average Cohen\u27s Kappa agreement was substantial for pelvic height (k=.63), fair for step length (k=.34), cervical extension (k=.40), trunk inclination (k=.35), and slight for shoulder extension (k=.16). The experienced raters out-performed the novice raters in all categories. Conclusion: The results of this study indicate that skilled raters are better able to identify the movement patterns included in the QYTS when compared to a validation measure as well have higher rates of interrater agreement than novice raters. Level of Evidence: 3

The Effect of Tackling Training on Head Accelerations in Youth American Football

Background: Many organizations have introduced frameworks to reduce the incidence of football related concussions through proper equipment fitting, coach education, and alteration of tackling technique. Purpose: The purpose of this study was to examine the effects of training in a vertical, head up tackling style on the number of head accelerations experienced while tackling in a controlled laboratory situation. The authors hypothesized that training in a head up tackling technique would reduce the severity of head acceleration experienced by participants. Design: Controlled Laboratory Study. Methods: Twenty-four participants (11.5 ± 0.6 years old, 60.5 ± 2.2 in, 110 ± 18.4 lbs.) with previous playing experience completed a one-day training session on tackling technique utilizing a tackling dummy. A subgroup of these participants completed an additional two days of training with a 48 hour retention test. Head accelerations were analyzed at baseline and end of training. Feedback consisted of verbal feedback utilizing the Qualitative Youth Tackling Scale (QYTS) and video tackling playback. Results: A significant reduction in the number of peak linear head accelerations over 10 g and peak rotational head accelerations over 1885 deg/s² were found in dummy tackling after training in both the one day and three day training regimens. A significant change in QYTS tackling form score was found between pretest and post-test (p=0.004). Participants with larger steps had a 2.28, 4.42 and 4.14 increased odds ratio of sustaining head accelerations over 10, 15 and 20 g respectively. Conclusions: Training in a vertical, head up tackling style decreased the number of head accelerations over threshold values sustained while tackling; decreased step length may be the driving factor in the effectiveness of this tackling form. Level of Evidence: Level 3

Long term behavior of two component back-fill grout mix used in full face mechanized tunneling

In mechanized tunneling the annular gap between the segmental lining and the surrounding soil caused by tunnel driving, must be backfilled almost instantaneously with an adequate grouting mortar when tunnelling in soils and particularly in urban area at low overburden. The main goal of this research is to investigate the grouting performance of two-component grout mix also when long curing time is considered

Novel Method for using Hand Recognition as Computer Remote Control with Computer Vision Techniques

Today, interaction between man-computer (HCI) is one of the most prominent goals. One of the important goals is to develop an independent control of external devices or static controls over a computer for simplified system and userfriendly interface. Detection and recognition of gestural parts of a person's hand plays a crucial role because it is used to perform almost all of the daily activities. This work is aimed at facilitating the way of exercising control over the PC using C++ programming language via machine vision libraries like OpenCV. The segmentation of the hand was performed in two stages: the first stage used a range of color with the HSV model, accompanied by morphological operations to minimize noise. The second stage, which was conducted after binarization, continued to seek the contour of the hand focusing on the most important features of its geometry. A convex hull and convexity defects were set to determine the type of gesture and assign a particular function to run on the computer. The center of the mass of the contour of the hand was located to obtain its coordinates (x, y). It was subsequently assigned to the mouse position connected to the PC to emulate the 2D scrolling on the screen, consistent to the movement of the hand. In comparison to the traditional input devices, this approach facilitated a convenient manipulation of computer tools, providing a greater control and user comfort

Characterisation and modelling of the plastic material behaviour and its application in sheet metal forming simulation

The application of simulation models in sheet metal forming in automotive industry has proven to be beneficial to reduce tool costs in the designing stage and for optimising current processes. Moreover, it is a promising tool for a material supplier to optimise material choice and development for both its final application and its forming capacity. The present practice requires a high predictive value of these simulations. The material models in these simulation models need to be developed sufficiently to meet the requirement of the predictions. For the determination of parameters for the material models, mechanical tests at different strain paths are necessary 1. Usually, the material models implemented in the simulation models are not able to describe the plastic material behaviour during monotonic strain paths sufficiently accurate 2. This is true for the strain hardening model, the influence of strain rate and the description of the yield locus in these models. A first stage is to implement the improved material models which describe this single strain path behaviour in a better way. In this work, different yield criteria, a hardening model and their comparison to experiments are described extensively. The improved material model has been validated initially on forming limit curves which are determined experimentally with Nakazima strips. These results will be compared with predictions using Marciniak-Kuczinsky-analysis with both the new material model and the conventional material model. Finally, the validation on real pressed products will be shown by comparing simulation results using different material models with the experimental data. The next challenge is the description of the material after a change of strain path. Experimental evidence given here shows that this behaviour cannot be treated using the classical approach of an equivalent strain as the only history variable

Organization of sensorimotor activity in anterior cruciate ligament reconstructed individuals: an fMRI conjunction analysis

IntroductionAnterior cruciate ligament reconstruction (ACLR) is characterized by persistent involved limb functional deficits that persist for years despite rehabilitation. Previous research provides evidence of both peripheral and central nervous system adaptations following ACLR. However, no study has compared functional organization of the brain for involved limb motor control relative to the uninvolved limb and healthy controls. The purpose of this study was to examine sensorimotor cortex and cerebellar functional activity overlap and non-overlap during a knee motor control task between groups (ACLR and control), and to determine cortical organization of involved and uninvolved limb movement between groups.MethodsEighteen participants with left knee ACLR and 18 control participants performed a knee flexion/extension motor control task during functional magnetic resonance imaging (fMRI). A conjunction analysis was conducted to determine the degree of overlap in brain activity for involved and uninvolved limb knee motor control between groups.ResultsThe ACLR group had a statistically higher mean percent signal change in the sensorimotor cortex for the involved > uninvolved contrast compared to the control group. Brain activity between groups statistically overlapped in sensorimotor regions of the cortex and cerebellum for both group contrasts: involved > uninvolved and uninvolved > involved. Relative to the control group, the ACLR group uniquely activated superior parietal regions (precuneus, lateral occipital cortex) for involved limb motor control. Additionally, for involved limb motor control, the ACLR group displayed a medial and superior shift in peak voxel location in frontal regions; for parietal regions, the ACLR group had a more posterior and superior peak voxel location relative to the control group.ConclusionACLR may result in unique activation of the sensorimotor cortex via a cortically driven sensory integration strategy to maintain involved limb motor control. The ACLR group's unique brain activity was independent of strength, self-reported knee function, and time from surgery

The Role of Histone Methylation and H2A.Z Occupancy during Rapid Activation of Ethylene Responsive Genes

Ethylene signaling pathway leads to rapid gene activation by two hierarchies of transcription factors with EIN3/EIL proteins as primary ones and ERF proteins as secondary ones. The role of chromatin modifications during the rapid gene activation is not known. In this work we studied trimethylated histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3), two opposite histone methylation marks for gene activity, during the induction course of three ethylene-responsive genes (ERF1, AtERF14 and ChiB). We found that the three genes displayed different histone modification profiles before induction. After induction, H3K4me3 was increased in the 5′ region and the gene body of ERF1, while H3K27me3 was decreased in the promoter of AtERF14. But the modification changes were later than the gene activation. Analysis of other rapidly inducible ERF genes confirmed the observation. In addition, histone H2A.Z occupancy on the three genes and the association of the H3K27me3-binding protein LHP1 with AtERF14 and ChiB were not affected by the inductive signal. However, the mutation of genes encoding H2A.Z and LHP1 attenuated and enhanced respectively the induction of target genes and altered H3K4me3. These results indicate that the induction of ethylene-responsive genes does not require immediate modulation of H3K4me3 and H3K27me3 and dissociation of LHP1 and H2A.Z from the targets, and suggest that the chromatin structure of the genes before induction is committed for transcriptional activation and that H3K4me3 is not required for ethylene-responsive gene activation, but may serve as a mark for gene activity