22 research outputs found
Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs
Background: Misoprostol is effective for ulcers associated with the use of nonsteroidal antiinflammatory drugs (NSAIDs) but is often poorly tolerated because of diarrhea and abdominal pain. We compared the efficacy of omeprazole and misoprostol in healing and preventing ulcers associated with NSAIDs. Methods: in a double-blind study, we randomly assigned 935 patients who required continuous NSAID therapy and who had ulcers or more than 10 erosions in the stomach or duodenum (or both) to receive 20 mg or 40 mg of omeprazole orally in the morning or 200 microg of misoprostol orally four times daily. Patients were treated for four weeks or, in the absence of healing, eight weeks. Treatment success was defined as the absence of ulcers and the presence of fewer than five erosions at each site and not more than mild dyspepsia. We then randomly reassigned 732 patients in whom treatment was successful to maintenance therapy with 20 mg of omeprazole daily, 200 microg of misoprostol twice daily, or placebo for six months. Results: at eight weeks, treatment was successful in 76 percent of the patients given 20 mg of omeprazole (233 of 308), 75 percent of those given 40 mg of omeprazole (237 of 315), and 71 percent of those given misoprostol (212 of 298). The rates of gastric-ulcer healing were significantly higher with 20 mg of omeprazole (but not 40 mg of omeprazole) than with misoprostol. Healing rates among patients with duodenal ulcers were higher with either dose of omeprazole than with misoprostol, whereas healing rates among patients with erosions alone were higher with misoprostol. More patients remained in remission during maintenance treatment with omeprazole (61 percent) than with misoprostol (48 percent, P=0.001) and with either drug than with placebo (27 percent, P<0.001). There were more adverse events during the healing phase in the misoprostol group than in the groups given 20 mg and 40 mg of omeprazole (59 percent, 48 percent, and 46 percent, respectively). Conclusions: the overall rates of successful treatment of ulcers, erosions, and symptoms associated with NSAIDs were similar for the two doses of omeprazole and misoprostol. Maintenance therapy with omeprazole was associated with a lower rate of relapse than misoprostol. Omeprazole was better tolerated than misoprostol
XXX Premi d'Honor de les Lletres Catalanes
Programa de l'acte de Proclamaci贸 i lliurament del XX Premi d'Hono
Premi d'honor de les lletres Catalanes
Programa de l'actuaci贸 musical dins l'acte de lliurament del 38猫 premi d'honor de les lletres Catalanes, el 6 de juny de 200
Acte de lliurament del XXXIV Premi d'Honor de les Lletres Catalanes 2002: Actuacions musicals
Programa de les actuacion musicals celebrades el 10 de juny de 2002, en el curs de la proclamaci贸 i lliurament del XXXIV Premi d'Honor de les Lletres Catalanes
La m煤sica a trav茅s de les seves formacions
Programa general del cicle de concerts i xerrades organitzat per Omnium Cultural amb motiu del Centenari del Palau de la M煤sica Catalan
Acte de lliurament del Premi d'Honor de les Lletres Catalanes 2001: Actuaci贸 musical
Programa de l'actuaci贸 musical celebrada el 31 de maig de 2001, en el curs de la proclamaci贸 i lliurament del XXXIII Premi d'Honor de les Lletres Catalanes
Festa de Maig de les lletres catalanes 1977
Programa de la Festa de Maig celebrada el 13 de maig de 197
Actuaci贸 de Maria del Mar Bonet i Manel Camp
Programa de l'actuaci贸 dins l'acte de lliurament del 36猫 premi d'Honor de les Lletres Catalanes 200
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