90 research outputs found
Thermal diffusivity of amorphous plastic materials
The paper presents thermal diffusivity data on amorphous plastic materials, obtained by means of a method previously developed by the authors. This methods ensures high sensitivity (<1%) and good reproducibility (<3%
High- sensitivity capacitance method for measuring thermal diffusivity and thermal expansion: results on aluminum and copper
Temperature-dependent effective third-order interatomic force constants from first principles
Thermal diffusivity and Biot number: a new experimental method
A new simple method is presented for measuring thermal diffusivity and Biot number in cylindrical samples made of relatively highly conducting materials, subjected to laminar air flow. The basic idea is a heat source in the middle section of the sample, acting also as a thermocouple; only one additional temperature sensor at the cylinder basis is required to give all information, without requiring any hypothesis about the effective time dependence of the heat source
L'Italia come modello per l'Europa e per il mondo nelle politiche sanitarie per il trattamento dell'epatite cronica da HCV
The World Health Organization foresees the
elimination of HCV infection by 2030. In light of this and the curre
nt, nearly worldwide, restriction in direct-acting agents
(DAA) accessibility due to their high price, we aimed to evaluate
the cost-effectiveness of two alternative DAA treatment
policies: Policy 1 (universal): treat all patients, regardless of the fibrosis stage; Policy 2 (prioritized): treat only priori
tized
patients and delay treatment of the
remaining patients until reaching stage F3. T
he model was based on patient’s data
from the PITER cohort. We demonstrated that extending HC
V treatment of patients in any fibrosis stage improves health
outcomes and is cost-effective
SoxD and SoxF in hematopoietic and vascular development.
Members of the Sry-related HMG box (SOX) family of transcription
factors are found throughout the animal kingdom and play widespread
roles during development. SoxF proteins are expressed in endothelial cells
during mouse vascular development and they are involved in the regulation
of different aspect in vascular development. In the last year, the key role of
Sox18 during early lymphatic specification has been well elucidated in
mouse. We decided to investigate specifically the role played by sox18 in
zebrafish lymphatic development and the interplay between sox18 and the
central lymphatic growth factor vegfc. The external development, the
optical clarity and the capacity to easily visualize the vascular tree and the
blood circulation using a variety of labelling techniques make the zebrafish
a useful model to study vascular morphogenesis in vivo. Since the initial
description of the zebrafish lymphatic system in 2006 it has emerged as a
very potent system to study lymphangiogenesis too. The presented data
show that the role of Sox18 in lymphangiogenesis is evolutionarily
conserved in zebrafish and suggest an unappreciated crosstalk between
Sox18 and one of the most potent lymphangiogenic growth factors.
SoxD proteins are an atypical SOX group because they lack a
transrepression or a transactivation domain, however they participate in
transcriptional activation and repression in different contexts. Sox13 has
been described to interact with Tcf1 in T cells, thereby preventing it from
binding to target genes, and influencing T-cell differentiation. In literature,
we found some hints that suggested a possible involvement for Sox13 in
vascular development. We identified the zebrafish SOX13 ortholog and,
due to our interest in the role of SOX genes in vascular development, we
decided to verify its potential activity. Zebrafish sox13 is expressed in the
II
central nervous system, transiently in the developing vasculature and in
primitive erythropoietic tissue. We observed that its knockdown impairs
angiogenesis in different vascular beds and intersomitic vessels defects are
apparently linked to an improper Notch signalling activation. We
discovered also an unproposed role for Sox13 in primitive erythropoieis.
We observed that sox13 knockdown affects primitive erythrocyte
maturation.
Altogether, the data collected during my PhD period contributed to the
enrichment of the complex network that engages SOX proteins during
embryo development
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