1,451 research outputs found
Clinical findings associated with a de novo partial trisomy 10p11.22p15.3 and monosomy 7p22.3 detected by chromosomal microarray analysis.
We present the case of an 18-month-old boy with dysmorphic facial features, developmental delay, growth retardation, bilateral clubfeet, thrombocytopenia, and strabismus, whose array CGH analysis revealed concurrent de novo trisomy 10p11.22p15.3 and monosomy 7p22.3. We describe the patient's clinical presentation, along with his cytogenetic analysis, and we compare the findings to those of similar case reports in the literature. We also perform a bioinformatic analysis in the chromosomal regions of segmental aneuploidy to find genes that could potentially explain the patient's phenotype
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Dosimetric Analysis of Neural and Vascular Structures in Skull Base Tumors Treated with Stereotactic Radiosurgery.
Objective To examine the relationship between the prescribed target dose and the dose to healthy neurovascular structures in patients with vestibular schwannomas treated with stereotactic radiosurgery (SRS). Study Design Case series with chart review. Setting SRS center from 2011 to 2013. Subjects Twenty patients with vestibular schwannomas treated at the center from 2011 to 2013. Methods Twenty patients with vestibular schwannomas were included. The average radiation dose delivered to healthy neurovascular structures (eg, carotid artery, basilar artery, facial nerve, trigeminal nerve, and cochlea) was analyzed. Results Twenty patients with vestibular schwannomas who were treated with fused computed tomography/magnetic resonance imaging-guided SRS were included in the study. The prescribed dose ranged from 10.58 to 17.40 Gy over 1 to 3 hypofractions to cover 95% of the target tumor volume. The mean dose to the carotid artery was 5.66 Gy (95% confidence interval [CI], 4.53-6.80 Gy), anterior inferior cerebellar artery was 8.70 Gy (95% CI, 4.54-12.86 Gy), intratemporal facial nerve was 3.76 Gy (95% CI, 3.04-4.08 Gy), trigeminal nerve was 5.21 Gy (95% CI, 3.31-7.11 Gy), and the cochlea was 8.70 Gy (95% CI, 7.81-9.59 Gy). Conclusions SRS for certain vestibular schwannomas can expose the anterior inferior cerebellar artery (AICA) and carotid artery to radiation doses that can potentially initiate atherosclerotic processes. The higher doses to the AICA and carotid artery correlated with increasing tumor volume. The dose delivered to other structures such as the cochlea and intratemporal facial nerve appears to be lower and much less likely to cause immediate complications when shielded
Quantum Phase Transitions in Coupled Dimer Compounds
We study the critical properties in cubic systems of antiferromagnetically
coupled spin dimers near magnetic-field induced quantum phase transitions. The
quantum critical points in the zero-temperature phase diagrams are determined
from quantum Monte Carlo simulations. Furthermore, scaling properties of the
uniform magnetization and the staggered transverse magnetization across the
quantum phase transition in magnetic fields are calculated. The critical
exponents are derived from Ginzburg-Landau theory. We find excellent agreement
between the quantum Monte Carlo simulations and the analytical results.Comment: 7 pages, 9 eps-figure
Adaptive design of nano-scale dielectric structures for photonics
Using adaptive algorithms, the design of nano-scale dielectric structures for
photonic applications is explored. Widths of dielectric layers in a linear
array are adjusted to match target responses of optical transmission as a
function of energy. Two complementary approaches are discussed. The first
approach uses adaptive local random updates and progressively adjusts
individual dielectric layer widths. The second approach is based on global
updating functions in which large subgroups of layers are adjusted
simultaneously. Both schemes are applied to obtain specific target responses of
the transmission function within selected energy windows, such as discontinuous
cut-off or power-law decay filters close to a photonic band edge. These
adaptive algorithms are found to be effective tools in the custom design of
nano-scale photonic dielectric structures.Comment: 4 pages Revtex, 4 embedded EPS figure
Evaluation of the hierarchical control of distributed Energy Storage Systems in islanded Microgrids based on Std IEC/ISO 62264
Forecasting Oxygen Demand in Treatment Plant Using Artificial Neural Networks
Modeling the wastewater treatment plant is difficult due to nonlinear properties of most of its different processes. Due to the increasing concerns over environmental effects of treatment plants considering the poor operation, fluctuations in process variables and problems of linear analyses, algorithms developed using artificial intelligence methods such as artificial neural networks have attracted a great deal of attention. In this research, first using regression analysis, the parameters of biological oxygen demand, chemical oxygen demand, and pH of the input wastewater were chosen as input parameter among other different parameters. Next, using error analysis, the best topology of neural networks was chosen for prediction. The results revealed that multilayer perception network with the sigmoid tangent training function, with one hidden layer in the input and output as well as 10 training nodes with regression coefficient of 0.92 is the best choice. The regression coefficients obtained from the predictions indicate that neural networked are well able to predict the performance of the wastewater treatment plant in Yazd
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