1,741 research outputs found
Clinical findings associated with a de novo partial trisomy 10p11.22p15.3 and monosomy 7p22.3 detected by chromosomal microarray analysis.
We present the case of an 18-month-old boy with dysmorphic facial features, developmental delay, growth retardation, bilateral clubfeet, thrombocytopenia, and strabismus, whose array CGH analysis revealed concurrent de novo trisomy 10p11.22p15.3 and monosomy 7p22.3. We describe the patient's clinical presentation, along with his cytogenetic analysis, and we compare the findings to those of similar case reports in the literature. We also perform a bioinformatic analysis in the chromosomal regions of segmental aneuploidy to find genes that could potentially explain the patient's phenotype
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Dosimetric Analysis of Neural and Vascular Structures in Skull Base Tumors Treated with Stereotactic Radiosurgery.
Objective To examine the relationship between the prescribed target dose and the dose to healthy neurovascular structures in patients with vestibular schwannomas treated with stereotactic radiosurgery (SRS). Study Design Case series with chart review. Setting SRS center from 2011 to 2013. Subjects Twenty patients with vestibular schwannomas treated at the center from 2011 to 2013. Methods Twenty patients with vestibular schwannomas were included. The average radiation dose delivered to healthy neurovascular structures (eg, carotid artery, basilar artery, facial nerve, trigeminal nerve, and cochlea) was analyzed. Results Twenty patients with vestibular schwannomas who were treated with fused computed tomography/magnetic resonance imaging-guided SRS were included in the study. The prescribed dose ranged from 10.58 to 17.40 Gy over 1 to 3 hypofractions to cover 95% of the target tumor volume. The mean dose to the carotid artery was 5.66 Gy (95% confidence interval [CI], 4.53-6.80 Gy), anterior inferior cerebellar artery was 8.70 Gy (95% CI, 4.54-12.86 Gy), intratemporal facial nerve was 3.76 Gy (95% CI, 3.04-4.08 Gy), trigeminal nerve was 5.21 Gy (95% CI, 3.31-7.11 Gy), and the cochlea was 8.70 Gy (95% CI, 7.81-9.59 Gy). Conclusions SRS for certain vestibular schwannomas can expose the anterior inferior cerebellar artery (AICA) and carotid artery to radiation doses that can potentially initiate atherosclerotic processes. The higher doses to the AICA and carotid artery correlated with increasing tumor volume. The dose delivered to other structures such as the cochlea and intratemporal facial nerve appears to be lower and much less likely to cause immediate complications when shielded
Identifying invariant solutions of wall-bounded three-dimensional shear flows using robust adjoint-based variational techniques
Invariant solutions of the Navier-Stokes equations play an important role in
the spatiotemporally chaotic dynamics of turbulent shear flows. Despite the
significance of these solutions, their identification remains a computational
challenge, rendering many solutions inaccessible and thus hindering progress
towards a dynamical description of turbulence in terms of invariant solutions.
We compute equilibria of three-dimensional wall-bounded shear flows using an
adjoint-based matrix-free variational approach. To address the challenge of
computing pressure in the presence of solid walls, we develop a formulation
that circumvents the explicit construction of pressure and instead employs the
influence matrix method. Together with a data-driven convergence acceleration
technique based on dynamic mode decomposition, this yields a practically
feasible alternative to state-of-the-art Newton methods for converging
equilibrium solutions. We successfully converge multiple equilibria of plane
Couette flow starting from inaccurate guesses extracted from a turbulent time
series. The variational method significantly outperforms the standard
Newton-hookstep method, demonstrating its superior robustness and suggesting a
considerably larger convergence radius
Quantum Phase Transitions in Coupled Dimer Compounds
We study the critical properties in cubic systems of antiferromagnetically
coupled spin dimers near magnetic-field induced quantum phase transitions. The
quantum critical points in the zero-temperature phase diagrams are determined
from quantum Monte Carlo simulations. Furthermore, scaling properties of the
uniform magnetization and the staggered transverse magnetization across the
quantum phase transition in magnetic fields are calculated. The critical
exponents are derived from Ginzburg-Landau theory. We find excellent agreement
between the quantum Monte Carlo simulations and the analytical results.Comment: 7 pages, 9 eps-figure
Adaptive design of nano-scale dielectric structures for photonics
Using adaptive algorithms, the design of nano-scale dielectric structures for
photonic applications is explored. Widths of dielectric layers in a linear
array are adjusted to match target responses of optical transmission as a
function of energy. Two complementary approaches are discussed. The first
approach uses adaptive local random updates and progressively adjusts
individual dielectric layer widths. The second approach is based on global
updating functions in which large subgroups of layers are adjusted
simultaneously. Both schemes are applied to obtain specific target responses of
the transmission function within selected energy windows, such as discontinuous
cut-off or power-law decay filters close to a photonic band edge. These
adaptive algorithms are found to be effective tools in the custom design of
nano-scale photonic dielectric structures.Comment: 4 pages Revtex, 4 embedded EPS figure
Quality Function Deployment: More Than a Design Tool
Purpose – This study investigates to what extent QFD can be used in quality improvement rather than design activities.
Design/methodology/approach – A framework was developed for implementation of QFD as a quality improvement tool. A case study approach is used to test this framework, and quality issues were analyzed using the framework in a ceramic tile manufacturing company.
Findings – The results showed considerable improvements in the critical quality characteristics identified and sales rates, demonstrating the potential of QFD to be used in assessing and prioritizing areas of improvement, and converting them into measurable process or product requirements. Research limitations/implications – One case study was completed. More studies would be beneficial to support current findings.
Practical implications – This framework provides structured approach and guidelines for practitioners in adapting QFD for quality improvements in existing products or processes.
Originality/value – This study proposes a new framework to use QFD in quality improvement activities, expanding its application areas. Moreover, the results of the literature study performed provide a valuable collection of practical QFD implementation examples. Keywords Quality function deployment (QFD), quality improvement, customer complaints, voice of customer (VOC), house of quality (HOQ)
Evaluation of the hierarchical control of distributed Energy Storage Systems in islanded Microgrids based on Std IEC/ISO 62264
Concurrent algorithms for transient FE analysis
Information on concurrent algorithms for transient finite element analysis is given in viewgraph form. Information is given on concurrent dynamic algorithms, interprocessor communication, the performance of the BAR problem on the 32 Processor Hypercube, computational efficiency and accuracy analysis
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