EFEKTIVITAS KOMBINASI DL-αTOKOFEROL DAN ASAM ASKORBAT TERHADAP KADAR LDL-OX, sCD36, sVCAM-1 DAN NO PADA ANAK SINDROM NEFROTIK

Latar Belakang: Stres oksidatif, disfungsi endotel dan inflamasi mendasari proses aterosklerosis pada anak sindrom nefrotik (SN). Kombinasi dl-α-tokoferol dan asam askorbat berpotensi menurunkan proses stress oksidatif dan disfungsi endotel banyak diteliti pada orang dewasa namun terbatas pada anak SN. Tujuan: Membuktikan pengaruh pemberian kombinasi dl-α-tokoferol dan asam askorbat terhadap Δ kadar LDL-ox sebagai marker stress oksidatif, reseptor makrofag sCD36, sVCAM-1 dan NO sebagai biomarker disfungsi endotel pada anak SN usia 1 – 15 tahun. Metode: Randomized pre test-post test control group design dilakukan pada anak SN usia 1- 15 tahun selama 12 minggu. Kelompok perlakuan diberi obat standar (prednison dosis penuh) dan kombinasi dl-α-tokoferol 10-15 mg /kg/hari & asam askorbat dengan dosis sama, dibagi 2 dosis secara oral. Kelompok kontrol menerima obat standar dan plasebo. Variabel LDL-ox, sCD36, sVCAM-1 diperiksa secara ELISA, NO secara kolorimetri. Analisis statistik digunakan uji Wilcoxon, uji t tidak berpasangan/Mann-Whitney U. Hasil: Rerata pretest-posttest kelompok perlakuan kadar LDL-ox (127,2 menjadi 89,5 U/L); sVCAM-1:(929,4 menjadi 868,4ng/mL); NO: (8,9 menjadi 8,5μM/L) menurun. Kadar sCD36 (72,5 menjadi 123,5 ng/mL) meningkat. Kelompok kontrol: LDL-ox (125,2 menjadi 76,7 U/L), sVCAM-1(1231,2 menjadi 1008,0 ng/mL), NO (8,2 menjadi 7,9μM) menurun,. sCD36(56,9 menjadi 61,7ng/mL) meningkat. Uji Wilcoxon kelompok perlakuan dan kontrol berturut-turut kadar LDL-ox p =0,039 dan 0,001, kadar sCD36 : p=0,163 & 0,088, sVCAM-1: p=0,306 & 0,122 dan NO: p=0,983 & 0,760. Δ LDL-ox -37.7 vs - 48.6U / L ; Δ sCD36: 51.1vs 17,2ng / mL; Δ sVCAM-1: -61.0 vs –223ng /mL ; ΔNO -0.4 vs- 0.6 mg/dL dengan uji beda berturut-turut p = 0,594; 0,327; 0,883; 0,864. Berdasarkan status remisi, uji beda kadar LDL-ox, Δ kadar LDL-ox dan kadar sVCAM-1 post test pada kelompok perlakuan berbeda bermakna dengan p=0,016; 0,047 dan 0,000. Kesimpulan: Pemberian kombinasi dl-α-tokoferol dan asam askorbat dosis 10-15 mg/kgBB/hari selama 12 minggu efektif menurunkan kadar stres oksidatif dan disfungsi endotel pada kelompok perlakuan yang remisi, tetapi tidak efektif terhadap Δ kadar LDL-ox, Δ sCD36, Δ sVCAM-1 dan Δ NO di antara dua kelompok. Kata kunci: Sindrom nefrotik, anti oksidan, stress oksidatif, disfungsi endotel Background: Oxidative stress, endothelial dysfunction and inflammation contribute to early atherosclerosis process in neprotic syndrome (NS). Administration of combination dl-α-tocopherol and ascorbic acid are potential in decreasing oxidative stress and endothelial dysfunction, investigated in adult but not yet in children. Objective: To prove that combined supplementation of dl-α-tocopherol and ascorbic acid on serum levels of oxidized LDL (ox-LDL), soluble scavenger receptor of macrophage CD36(sCD36), soluble vascular cellular adhesion molecule (sVCAM-1) and nitric oxide (NO) level in NS of 1- 15 years old. Methods: A randomized pre test–post test control group design was done for 12 weeks. Treatment group was given standard therapy and dl-α-tocopherol 10 -15 mg/kgBW/day plus ascorbic acid in the same dose, twice daily orally. Control group was given steroid therapy (standard) and placebo. Serum level of ox-LDL, sCD36, sVCAM-1 were measured by ELISA and NO by colorimetri. Analysis was done by Wilcoxon, independent t test or Mann-Whitney U test. Results: The mean level of pre and posttest of ox-LDL (127.2 to 89.5 U/L), sVCAM-1(929.4 to 868.4 ng/mL) and NO (8.9 to 8.5 μM/L) were decreased, but the level of sCD36 (72.5 to 123.5 ng/mL) increased in the treatment group. In control group, the mean level of ox-LDL(125.2 to 76.7 U/L), sVCAM-1(1231.2 to 1008.0 ng/mL), NO ( 8.2 to 7.9 μM) were decreased, but sCD36 (56.9-61.7 ng/mL) was increased. The Wilcoxon test of ox-LDL levels showed p :0.039 in treatment group and p=0.001 in control group. P value in treatment and control group of sCD36 levels were 0.163 and 0.088; sVCAM-1 levels p value = 0.306 & 0.122 and NO levels were p value =0.983 and 0.760. The Δ level of ox-LDL on treatment group compared to control was -37.7vs - 48.6U/L ; Δ sCD36: 51.1vs 17.2ng/mL; Δ sVCAM-1: -61.0 vs –223ng/mL ; Δ NO: -0.4 vs -0.6mg/dL. P value of Δ ox-LDL, ΔsVCAM-1, Δ sCD36 , ΔNO were 0.594, 0.327, 0.883, 0.864, respectively. According to remission state at the end of the study p value level of ox-LDL, Δ ox-LDL and level of sVCAM-1 in treatment group were 0,016; 0,047 and 0,000 respectively. Conclusions: Combined supplementation of dl-α-tocopherol and ascorbic acid 10 –15 mg/kgBW/day for 12 weeks decreased of stress oxidative and endothelial disfunction biomarker in remission state of the treatment group but did not effective to decrease level of Δ ox-LDL, Δ sCD36, Δ sVCAM –1 and Δ NO between two groups. Keywords: Nephrotic syndrome, antioxidant, oxidative stress, endothelial dysfunctio

Pengaruh Suplementasi Minyak Selama enam bulan terhadap Pertumbuhan anak masa penyapihan

Background: Weaning period is a critical period in developing country. At this time children are growing fast but often they receive food below their daily requerement. Oil is a high energy food but used. The aim of the study was to find whether oil suplementtation for six month can improve growth rarely and accepted by children. Methods: This study used randomized controoled trial. the study was held on 2003 at bulu lor village,east of Semarang,Central Java. 184 subject from 6-18 month devided into 2 group.Oil group ( 99 children ) received 200 cc oil every 2 weeks and the placebo group (85 children) received 200cc syrupus simplex. Each child received 3 times a tea spoonfull per day mixed in complementary food.Weight (in gram)of subject were meeasured eevery two weeks until 24 weeks (6 month).Height (in cm) were measured every 4 weeks (a month) until 24 weeks. Result : On the average fat intakes was low in 52.2% of the children. The complience in study was 88.6%.There were differnt in ΔWAZ Score (p=0,000) dan ΔHAZ Score (p= 0,000) between treated and non treated group among 6-12 month old children.However , among 12 -18 olds children the differnce was not significant.Diarrhea happened in 2 children and was overcome by giving the oil little by little. Conclussion : Oil Suplementation gives effect on growth in 6 – 12 month old group.Infant of 6 -18 month can receive oil incorporate in their weaning foo

PENGARUH SUPLEMENTASI MINYAK SELAMA ENAM BULAN PADA MAKANAN SAPIHAN ANAK UMUR 6 -18 BULAN TERHADAP PERTUMBUHAN DAN PROFIL LIPID DI KELURAHAN BULU LOR KECAMATAN SEMARANG UTARA

Weaning period is a critical period in developing country. At this time children are growing fast but often they receive not enough food they need or caused by recurrent infection, therefore, they become growth faltering . Oil is a high callory food that recommended by WHO, but rare in use. Early study was held by education about The improvement complementary feeding with addition of oil, coconut milk, fish, and beans with given butter that significantly increase nutritional status with z-score for height for age . This study is to fmd whether oil suplementation for six months can increase growth ( weight and height according to z-score ). This study used randomized controlled trial. 184 samples from 6-18 months children devided into 2 group. Oil group ( 99 children ) received 200cc oil every 2 weeks and the placebo group ( 85 children ) received 200cc sirupus simplex, all in the same shape bottle. Each child received 3 times a tea spoonfull per day mixed in complementary food when it still warm. Weight ( in gram ) of subjects were measured every two weeks with digital scale while they were given another bottle until the 12th bottle ( 24 weeks = 6 months ). Height ( in cm ) were measured every 4 weeks ( a month ) when the subject wass laying on board. At that time subjects also given the bottle until the sixth month. The study was held at Sulu Lor district, Semarang Utara. Effect of the oil or sirupus and residual that not consumpted was recorded every two weeks by nurse was trained. From discriptive analysis, age, sex, mother's education, child, and parent's wage are not significant to growth (with p= 0,809, p = 0,104 ; p= 0,713 ; p= 0,402, p= 0,141 ). Mean callory of lipid from oil and placebo is not significant, mean Lipid intake from population is low ( 96 children : 52,2 % ), very low ( 43 children : 23,4 % ). Mean cholesterol from oil group is higher ( 157,3 mg/dl ) than placebo ( 142,9 mg/di ) with p = 0,001 ( significant ). The changes of z-score for weight for age from oil group is significantly different ( p= 0,000 ). The changes of z-score for height for age is significantly different (p= 0,001). But the changes of z-score for weight and height is not significant (p= 0,062) That the lipid was not measure before is the limitation of this study. Lipid is only measure after the treatment. The lipid measured only 10% ( 20 samples; 10 from oil group, 10 from placebo group, decided with lottery ) from all samples. Food record is not repeated to know if there is another callory consumtion from another source.Masa penyapihan merupakan masa yang kritis di negara sedang berkembang. Pada masa ini anak masih tumbuh cepat, tetapi justru sering mendapat makanan yang tidak mencukupi kebutuhan atau pada umumnya disebabkan oleh infeksi yang sering atau lama sehingga sering terjadi Growth faltering. Minyak merupakan sumber kalori yang tinggi dan dianjurkan oleh WHO, namun jarang digunakan. Penelitian sebelumnya dengan cara pemberian penyuluhan peningkatan mutu makanan pendamping ASI dengan pemberian minyak, santan, ikan dan kacang-kacangan memberikan hasil yang bermakna terhadap peningkatan status gizi dengan Z score tinggi badan menurut umur. Adapun tujuan penelitian ini adalah untuk mengetahui apakah suplementasi minyak selama enam bulan dapat tnempengaruhi pertumbuhan yaitu terdapat peningkatan berg badan dan panjang badan berdasarkan nilai Z Score. Penelitian ini menggunakan metode uji acak terkontrol. Sampel sebanyak 184 anak umur 6 sampai 18 bulan terbagi menjadi dua kelompok yaitu kelompok minyak (99 anak) dan kelompok plasebo (85 anak). Kelompok minyak mendapatkan 200 cc minyak tiap dua minggu sekali.. Kelompok plasebo mendapatkan 200 cc sirupus simpleks dalam botol kemasan yang sama Masing = masing diberikan sebanyak 3 x satu sendok obat sehari, dicampurkan pada makanan sapihannya saat masih hangat. Berat badan (dalam gram) subyek ditimbang nap' due minggu sekali dengan timbangan digital, saat subyek mengambil botol berikutnya sampai botol ke-12 (24 minggu= 6 bulan). Sisa minyak/sirupus simpleks dicatat tiap dua minggu sekali. Tinggi badan (dalam cm) diukur tiap 4 minggu (satu bulan ) sekali dengan ukuran panjang badan berbaring saat penderita datang mengambil both) sampai bulan keenam. Tempat penelitian di Kelurahan Bulu Lor , kecamatan Semarang Utara. Dari analisis diskriptif, usia awal, jenis kelamin, pendidikan ibu,jumlah anak, penghasilan orang tua tidak ada perbedaan bennakna terhadap pertumbuhan anak sebelum perlakuan dengan nilai p > 0,05 ( p= 0,809, p = 0,104 ; p= 0,713 ; p= 0,402, p= 0,141). Rata-rata kalori berasal dan lemak antara plasebo dan minyak tidak ada perbedaan, tingkat asupan lemak rata-rata pada populasi adalah kurang (96 anak; 52,2 %), berikutnya kurang sekali (43 analc;23,4 %). Nilai rerata kadar kolesterol pada kelompok minyak lebih tinggi yaitu 157,3 mg/di dibanding plasebo 142,9 mg/di berbecla bennakna (p= 0,001). Perubahan Z score berat badan terhadap umur menurut kelompok suplementasi berbeda bet-maim dengan p = 0,000. Perubahan Z score panjang badan terhadap umur berbeda secara bennakna dengan p = 0,001. Tetapi perubahan Z score Berat badan dan panjang badan tidak berbeda secara bermakna dengan p= 0,062. Kelemahan penelitian ini adalah tidal< mengukur kadar lemak sebelum perlakuan, tapi pengulcuran kadar lemalc hanya sesudah perlakuan. Jutnlah sampel yang diukur kadar lemalaiya hanya 10 % dari jumlah subyek keseluruhan yaitu 20 orang ( 10 dari kelompok plasebo dan 10 dari kelompok minyalc yang ditentulcan secara undian). Food record ulang tidalc dilalculcan untuk menilai adanya konsumsi peninglcatan energi dari makanan lain. Saran : perlu dilakulcan pengulatran kadar kolesterol ulang untuk semua subyek atau sub sampel yang lebih besar setelah 6 bulan atau satu tahun tanpa suplementasi minyak

PENGARUH SUPLEMENTASI MINYAK SELAMA ENAM BULAN TERHADAP PERTUMBUHAN ANAK MASA PENYAPIHAN

Background : Weaning period is a critical period in developing country. At this time growth-spurt occurs but they often did not receive enough food leading to growth faltering happens . Oil is a high calory source of food but seldom used. Z- score is deviation standard unit to measure nutritional status for children using weight for age (WAZ ), height for age(HAZ) and weight for height (WHZ) . The growth is normal when weight or height is in the same percentile. Aim of study to define whether six months oil supplementation can increase the Z-score . Methods : A randomized controlled that was done at Bulu Lor, a coastal village, North Semarang with a low socio-economic level. 184 subjects aged 6-18 months devided into 2 groups: oil group ( 99 children ) received 200 cc oil every 2 weeks and the placebo group ( 85 children ) received 200 cc syrupus simplex, in a similar bottle. Each child received 3 times 5 ml daily mixed in warm weaning food. Weight ( in gram ) of subjects were measured every two weeks with digital scale while they were given another supply until the 12th bottle ( 24 weeks = 6 months ). Height ( in cm ) were measured every 4 weeks ( a month ) in supine position. The remnants of oil or syrupus were recorded every two weeks by a trained nurse. Result : Fat intake was defined as very low < 25 % in 23,4 %, low 25- < 35 % in 52,2 % of the children. The mean calory intake of fat from oil and placebo is not significantly different before the study. Energy intake was 817 Kcal per day for 6 — 12 month group and 818 Kcal per day for 12 — 18 month group. The remaining oil not consumed was < 5 % on 96,1 % subject. A t test showed that the changes of a WAZ-score (p= 0,000 ) and AHAZ-score were significantly different (p= 0,000) from oil group for 6 — 12 month. But A WAZ-score(p=0,382) and AHAZ score(p=0,083) were not significantly different for 12 -18 month. Conclusion : Oil is acceptable for infants. Six month oil supplementation in infants 6 —12 month increase the growth significantly. Latar belakang : Masa penyapihan merupakan masa kritis bagi anak di negara sedang berkembang. Pada masa ini anak masih tumbuh cepat, tetapi justru sering mendapat makanan yang tidak mencukupi kebutuhan. Minyak merupakan sumber kalori yang tinggi namun jarang digunakan. Z —score dianjurkan untuk digunakan menilai keadaan gizi balita. Z —score adalah unit simpang baku yang dapat dinyatakan sebagai berat badan menurut umur (WAZ), panjang badan menurut umur(HAZ) atau berat badan menurut panjang badan (VVHZ). Anak tumbuh normal bila berat badan dan panjang badannya berada pada persentil atau pita pertumbuhan yang sama. Tujuan penelitian: untuk mengetahui apakah suplementasi minyak selama enam bulan dapat meningkatkan Z- Score. Metode : Penelitian ini menggunakan metode uji acak terkontrol, dilakukan di Kelurahan Bulu Lor, Kecamatan Semarang Utara, merupakan kampung kota daerah pantai dengan penghasilan menengah ke bawah. Subyek sebanyak 184 anak umur 6 sampai 18 bulan yang secara acak diberi minyak (99 anak) dan plasebo (85 anak). Kelompok minyak mendapatkan 200 cc minyak hap dua minggu sekali dan kelompok plasebo mendapatkan 200 cc sirupus simpleks dalam botol kemasan yang sama . Masing — masing diberikan sebanyak 3 x satu sendok obat sehari (15 cc), dicampurkan pada makanan sapihannya saat masih hangat. Berat badan subyek (dalam grarn) ditimbang hap dua minggu sekali dengan timbangan digital pada saat mengambil botol berikutnya sampai botol ke-12 (24 minggu= 6 bulan). Tinggi badan (dalam cm) diukur flap 4 minggu (satu bulan ) sekali dengan ukuran panjang badan berbaring saat penderita datang mengambil botol sampai bulan ke-enam Sisa minyak/sirupus simpleks dicatat hap dua minggu sekali. Hasil : Rata-rata tingkat asupan lemak < 25 % adalah 23,4 % anak, sedangkan antara 25 - < 35 sebanyak 52,2 % anak . Sebelum penelitian tidak ada perbedaan rata-rata asupan kalori berasal dart lemak antara plasebo dan minyak. Asupan energi rata-rata per had adatah 817 Ickatatari untuk kelompok umur 6 — 12 bulan dan 818 kkal/hari untuk anak 12 — 18 bulan. Ketaatan subyek mengikuti penelitian + 88,6%. Sisa minyak yang tidak dikonsumsi < 5 % pada 96,1 % subyek, Uji t menunjukkan terdapat perbedaan bermakna nilai AWAZ score (p=0,000) dan A HAZ score (p= 0,000)pada kelompok usia 6 — 12 bulan. Tetapi pada usia 12-18 bulan AWAZ score(p=0,382) dan A HAZ score (p=0,083) menunjukkan peningkatan tidak bermakna. Kesimpulan : Minyak dapat diterima oleh anak. Pemberian suplementasi minyak selama 6 bulan pada anak umur 6 — 18 bulan meningkatkan pertumbuhan pada kelompok umur 6 —12 bulan

Hemolytic uremic syndrome and hypertensive crisis post dengue hemorrhagic fever: a case report

Hemolytic-uremic syndrome (HUS) clinically manifests as acute renal failure, hemolytic anemia and thrombocytopenia. Acute renal failure with oliguria, hypertension, and proteinuria usually develops in affected patients.1,2 In children under 15 years of age, typical HUS occurs at a rate of 0.91 cases per 100,000 population.3 The initial onset of this disease usually happens in children below 3 years of age. Incidence is similar in boys and girls. Seasonal variation occurs, with HUS peaking in the summer and fall. In young children, spontaneous recovery is common. In adults, the probability of recovery is low when HUS is associated with severe hypertension.

Combined supplementation with α-tocopherol and vitamin C improves the blood pressure of pediatric idiopathic nephrotic syndrome patients

Summary: The purpose of the present study was to investigate the effects of combined supplementation with α-tocopherol and vitamin C on blood pressures and levels of ox-LDL and NOx in with pediatric idiopathic nephrotic syndrome patients. A total of thirty-six pediatric idiopathic nephrotic syndrome patients was involved in the study, which was assigned randomly into two groups, the control group of pediatric idiopathic nephrotic syndrome patients who received a standard therapy and placebo and the group of pediatric idiopathic nephrotic syndrome patients who received a standard therapy plus α-tocopherol and vitamin C. α-tocopherol and vitamin C were administered at a dose of 10–15 mg/kg/day for 12 weeks. An analysis of lipid profile and NOx was performed by means of a spectrophotometer. An analysis of ox-LDL was performed by using the enzyme-linked immunosorbent assay technique. There was a significant decrease in the number of prehypertensive and hypertensive patients in the supplementation group relative to the control group (p  0.50). In conclusion, the combined supplementation with α-tocopherol and vitamin C may improve blood pressure in pediatric idiopathic nephrotic syndrome patients. Thus, combination of α-tocopherol and vitamin C can be used in the clinical management of pediatric idiopathic nephrotic syndrome. Keywords: Antioxidants, Hypertension, Oxidative stress, Nitric oxide, LDL oxidatio

Correlation between lipid profile and C-reactive protein in children with nephrotic syndrome

Background Nephrotic syndrome (NS) causes dyslipidemia in children, which can be long term or intermittent. Dyslipidemia has long been established as a risk factor for atherosclerosis. An early sign of atherosclerosis is elevated high sensitivity C-reactive protien (hsCRP). Atherosclerosis early in life, especially in childhood, warrants an assessment for NS. Study on a correlation between lipid profile and hsCRP, as a marker of atherosclerosis, in pediatric NS patients has been limited. Objective To assess for a correlation between lipid profile and hsCRP in childhood nephrotic syndrome. Methods This cross-sectional study was undertaken on 29 children with NS in Dr. Kariadi Hospital. Serum hsCRP, total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were examined in the active phase. Spearman’s test was used to analyze a possible correlation between total cholesterol, LDL, HDL and hsCRP levels. Results Mean levels of total cholesterol (454 mg/dL) and LDL (288 mg/dL) in this study were high, while the HDL level (55 mg/dL) was normal, according to US Department of Health and Human Services classifications. The median hsCRP level was 0.33 mg/L and 9 (31%) subjects had high hsCRP levels of more than 1 mg/L. There was a positive correlation between LDL level and hsCRP (r=0.423; P<0.05). Conclusions There is a weak positive correlation between LDL and hsCRP levels in children with NS

Stent Angioplasti pada Anak Hipertensi Akibat Stenosis Arteri Renalis di RSUP Dr. Kariadi

Background : Renal artery stenosis (RAS) causes 5-10% of all secondary hypertension (HT) in children. Percutaneous transluminal angioplasty (PTA) has proven beneficial for adult patients, but for a children there are varying result. This paper is to report the management of PTA in HT children due to RAS in Dr. Kariadi Hospital. Case report: Nine years 8 months boy with stage II HT since 4 years old, in a good nutritional status, complaints headaches, no family history of hypertension. Treatment with of nifedipine, captopril, valsartan and furosemide has not improved. Four months ago, the patient was treated by the Children's Nephrology and Radiology Division in Dr. Kariadi Hospital for 4 days. initial blood pressure 150/100 mmHg (stage II HT), normal eye examination, heart and kidney function, the angiographic results obtained severe right middle renal artery stenosis.teh stenosis reduced by PTA with dilated balloons up to 30%. One day after the procedure, blood pressure decreased to stage I HT, no complication involved, and the patient was discharged on day 4, with nifedipine, valsartan to control HT and aspilet as anti platelet aggregation. Evaluation 4 months after PTA obtained normal blood pressure. Discussion: HT renovascular children e.c. unilateral RAS performed by PTA has a good prognosis. Unilateral RASre-stenosis rates are less than 30%. Anti-hypertensive therapy is needed after ballooning or angioplasty stents. PTA in Dr. Kariadi Hospital can managed patient to make blood pressure normal. Conclusion: PTA management is an option in children with HT renovasculere.c SAR. Dr. Kariadi Hospital can be a referral&nbsp; to manage the case. Keywords: pediatric hypertension, RAS, PTA, Dr. Kariadi Hospital &nbsp; Latar belakang : Stenosis arteri renalis (SAR) menyebabkan 5-10%&nbsp; dari seluruh hipertensi (HT) sekunder pada anak. Percutaneous transluminal angioplasty (PTA) terbukti bermanfaat untuk pasien dewasa, namun pada anak hasilnya bervariasi. Tujuan makalah ini melaporkan tatalaksana PTA pada anak HT akibat SAR di RSUP dr Kariadi. Laporan kasus : Anak laki laki 9 tahun 8 bulan dengan HTderajatII sejak usia 4 tahun, status gizi baik, keluhan kadang-2 sakit kepala, tidak ada riwayat keluarga hipertensi. Pengobatan nifedipin, kaptopril, valsartan dan furosemid belum membaik.&nbsp; Empat bulan yang lalu pasien di rawat oleh Divisi Nefrologi Anak dan Radiologi di RSUP dr Kariadi selama 4 hari. Tekanan darah saat masuk 150/100 mmHg, pemeriksaan mata, fungsi ginjal dan jantung normal, Hasil angiografi didapatkan stenosis berat arteri renalis kanan pertengahan, dilanjutkan PTA dengan stent post dilatasi dengan balon, stenosis mejadi 30%. Satu hari paska tindakan, tekanan darah menurun menjadi HT derajat I, tidak ada kelainan dan dipulangkan pada hari ke 4, mendapat nifedipin, valsartan dan aspilet sebagai anti agregasi trombosit. Evaluasi 4 bulan paska PTA didapatkan tekanan darah normal. Pembahasan : HT renovaskuler anak e.c.SAR unilateral yang dilakukan PTA mempunyai prognosis baik. Angka re-stenosis SAR unilateral kurang dari 30%. Terapi anti-hipertensi diperlukan setelah pemasangan balon atau stent angioplasti. PTA di RSUP dr Kariadi berhasil membuat tekanan darah menjadi normal. Kesimpulan :Manajemen PTA merupakan pilihan pada anak dengan HT renovaskuler e.c SAR. RSUP dr Kariadi dapat menjadi rujukan dalam tatalaksana kasus tersebut. Kata kunci : hipertensi anak, SAR, PTA, RSUP dr Kariad