Perioperative Glycemic Management

Proposals and Goals: 1. We propose creating a standard easy to use and safe protocol for glycemic management for same day/elective surgical patients. 2. Following implementation in same day and elective surgical procedures, we propose expanding the protocol to be effective in urgent and emergent inpatient surgical procedures.https://jdc.jefferson.edu/patientsafetyposters/1068/thumbnail.jp

Standardized Consent Forms for Surgical Procedures: An Intervention to Improve the Resident-led Informed Consent Process

Objectives and Goals: To provide high quality, consistent consent forms for common surgical procedures and improve resident workflow by creating and implementing standardized printed consents for common surgical procedures. These consents will be used by residents consenting patients in the ED or inpatient setting. Consents shall include standardized procedure descriptions, risks and benefits of the procedure, and alternative treatment option descriptions, risks and benefitshttps://jdc.jefferson.edu/patientsafetyposters/1057/thumbnail.jp

NGC 1866: First Spectroscopic Detection of Fast Rotating Stars in a Young LMC Cluster

High-resolution spectroscopic observations were taken of 29 extended main sequence turn-off (eMSTO) stars in the young ($\sim$200 Myr) LMC cluster, NGC 1866 using the Michigan/Magellan Fiber System and MSpec spectrograph on the Magellan-Clay 6.5-m telescope. These spectra reveal the first direct detection of rapidly rotating stars whose presence has only been inferred from photometric studies. The eMSTO stars exhibit H-alpha emission (indicative of Be-star decretion disks), others have shallow broad H-alpha absorption (consistent with rotation $\gtrsim$150 km s$^{-1}$), or deep H-alpha core absorption signaling lower rotation velocities ($\lesssim$150 km s$^{-1}$ ). The spectra appear consistent with two populations of stars - one rapidly rotating, and the other, younger and slowly rotating.Comment: 9 pages, 4 figures, Accepted for publication in ApJ Letter

Vertex Reconstruction Using a Single Layer Silicon Detector

Typical vertex finding algorithms use reconstructed tracks, registered in a multi-layer detector, which directly point to the common point of origin. A detector with a single layer of silicon sensors registers the passage of primary particles only in one place. Nevertheless, the information available from these hits can also be used to estimate the vertex position, when the geometrical properties of silicon sensors and the measured ionization energy losses of the particles are fully exploited. In this paper the algorithm used for this purpose in the PHOBOS experiment is described. The vertex reconstruction performance is studied using simulations and compared with results obtained from real data. The very large acceptance of a single-layered multiplicity detector permits vertex reconstruction for low multiplicity events where other methods, using small acceptance subdetectors, fail because of insufficient number of registered primary tracks.Comment: accepted for publication in Nucl. Instr. Meth.

DNA double strand breaks repair and apoptosis induction in peripheral blood lymphocytes of head and neck cancer patients

Aim: To evaluate the generation and repair of DNA double strand breaks (DSBs) as a critical factors that define the efficiency of radiation therapy of cancer patients. Methods: Peripheral blood lymphocytes obtained from 18 patients with head and neck squamous cell carcinoma (HNSCC) and 18 healthy donors were studied. The efficiency of DSBs repair after genotoxic treatment with hydrogen peroxide and γ-radiation were examined by neutral comet assay. MTT assay was used for cell viability analysis and Annexin V-FITC kit specific for kinase-3 was employed to determine apoptosis. Results: Lymphocytes from HNSCC patients were sensitive to genotoxic treatment and displayed impaired DSBs repair. Finally, as a consequence of this finding we have evidenced higher rate of apoptosis induction after γ-radiation treatment of lymphocytes from HNSCC patients than those from healthy controls. Conclusions: DSBs repair and increased apoptosis in cells of patients with head and neck cancer is relevant for efficient therapy of HNSCC

Integrated parameters of star clusters: A comparison of theory and observations

(Abridged) This paper presents integrated magnitude and colours for synthetic clusters. The integrated parameters have been obtained for the whole cluster population as well as for the main-sequence (MS) population of star clusters. We have also estimated observed integrated magnitudes and colours of MS population of galactic open clusters, LMC and SMC star clusters. It is found that the colour evolution of MS population of star clusters is not affected by the stochastic fluctuations, however these fluctuations significantly affect the colour evolution of the whole cluster population. The fluctuations are maximum in $(V-I)$ colour in the age range 6.7 $<$ log (age) $<$ 7.5. Evolution of integrated colours of MS population of the clusters in the Milky Way, LMC and SMC, obtained in the present study are well explained by the present synthetic cluster model. The observed integrated $(B-V)$ colours of MS population of LMC star clusters having age $\geq$ 500 Myr seem to be distributed around $Z=$ 0.004 model, whereas $(V-I)$ colours are found to be more bluer than those predicted by the $Z=$ 0.004 model. $(V-I)$ vs $(B-V)$ two-colour diagram for the MS population of the Milky Way star clusters shows a fair agreement between the observations and present model, however the diagrams for LMC and SMC clusters indicate that observed $(V-I)$ colours are relatively bluer. Possible reasons for this anomaly have been discussed.Comment: 35 pages, 20 figs, accepted for publication in MNRA

Plumo: An Ultralight Blockchain Client

Syncing the latest state of a blockchain can be a resource-intensive task, driving (especially mobile) end users towards centralized services offering instant access. To expand full decentralized access to anyone with a mobile phone, we introduce a consensus-agnostic compiler for constructing ultralight clients, providing secure and highly efficient blockchain syncing via a sequence of SNARK-based state transition proofs, and prove its security formally. Instantiating this, we present Plumo, an ultralight client for the Celo blockchain capable of syncing the latest network state summary in just a few seconds even on a low-end mobile phone. In Plumo, each transition proof covers four months of blockchain history and can be produced for just $25 USD of compute. Plumo achieves this level of efficiency thanks to two new SNARK-friendly constructions, which may also be of independent interest: a new BLS-based offline aggregate multisignature scheme in which signers do not have to know the members of their multisignature group in advance, and a new composite algebraic-symmetric cryptographic hash function

Molecular Mechanisms Leading from Periodontal Disease to Cancer

Periodontitis is prevalent in half of the adult population and raises critical health concerns as it has been recently associated with an increased risk of cancer. While information about the topic remains somewhat scarce, a deeper understanding of the underlying mechanistic pathways promoting neoplasia in periodontitis patients is of fundamental importance. This manuscript presents the literature as well as a panel of tables and figures on the molecular mechanisms of Porphyromonas gingivalis and Fusobacterium nucleatum, two main oral pathogens in periodontitis pathology, involved in instigating tumorigenesis. We also present evidence for potential links between the RANKL–RANK signaling axis as well as circulating cytokines/leukocytes and carcinogenesis. Due to the nonconclusive data associating periodontitis and cancer reported in the case and cohort studies, we examine clinical trials relevant to the topic and summarize their outcome