374 research outputs found
Numerical study of duality and universality in a frozen superconductor
The three-dimensional integer-valued lattice gauge theory, which is also
known as a "frozen superconductor," can be obtained as a certain limit of the
Ginzburg-Landau theory of superconductivity, and is believed to be in the same
universality class. It is also exactly dual to the three-dimensional XY model.
We use this duality to demonstrate the practicality of recently developed
methods for studying topological defects, and investigate the critical behavior
of the phase transition using numerical Monte Carlo simulations of both
theories. On the gauge theory side, we concentrate on the vortex tension and
the penetration depth, which map onto the correlation lengths of the order
parameter and the Noether current in the XY model, respectively. We show how
these quantities behave near the critical point, and that the penetration depth
exhibits critical scaling only very close to the transition point. This may
explain the failure of superconductor experiments to see the inverted XY model
scaling.Comment: 17 pages, 18 figures. Updated to match the version published in PRB
(http://link.aps.org/abstract/PRB/v67/e014525) on 27 Jan 200
Superconducting Coherence and the Helicity Modulus in Vortex Line Models
We show how commonly used models for vortex lines in three dimensional
superconductors can be modified to include k=0 excitations. We construct a
formula for the k=0 helicity modulus in terms of fluctuations in the projected
area of vortex loops. This gives a convenient criterion for the presence of
superconducting coherence. We also present Monte Carlo simulations of a
continuum vortex line model for the melting of the Abrikosov vortex lattice in
pure YBCO.Comment: 4 pages RevTeX, 2 eps figures included using eps
Control of lysozyme gene expression in differentiating HL-60 cells
We have investigated the control of lysozyme gene expression in HL-60 cells induced to differentiate into macrophage-like cells with phorbol myristate acetate (PMA). Differentiation, as evidenced by cellular adherence, and morphological changes corresponded temporally to an increase in nonspecific esterase activity. The lysozyme concentration in the medium of uninduced HL-60 cells was 10 Μg/10 7 cells. increasing to a maximum of 46 Μg/10 7 cells after 48 h incubation with PMA (16 nm). At 72 h the lysozyme concentration decreased to 16 Μg/10 7 cells. Intracellular lysozyme activity remained constant throughout differentiation. If HL-60 cells were exposed to PMA for 24 h, washed, then maintained in normal medium, they differentiated normally, confirming their irreversible commitment to differentiate. The increase in lysozyme secretion by these cells, however, is markedly blunted suggesting that continued PMA treatment of differentiated cells is required for their secretion of lysozyme. There is no change in the rate of extracellular degradation of lysozyme during differentiation. The level of lysozyme mRNA does not correlate directly with the amount of lysozyme secreted into the medium. Hybridization of uninduced HL-60 cell RNA with a chicken lysozyme cDNA probe demonstrates moderate hybridization. There is a modest (five-fold) increase in lysozyme mRNA between 0 and 36 h of exposure to PMA, corresponding to the burst of lysozyme secretion by these cells. The lysozyme mRNA decreases to a level which is lower than the original baseline by 72 h, when the cells are still secreting substantial amounts of lysozyme. These data suggest that both transcriptional and post-transcriptional controls are operative in the control of lysozyme gene expression during the differentiation of HL-60 cells. They also imply that lysozyme secretion is not a necessary component in the macrophage-monocyte differentiation of these cells.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/71582/1/j.1365-2141.1985.tb07380.x.pd
Field-induced XY behavior in the S=1/2 antiferromagnet on the square lattice
Making use of the quantum Monte Carlo method based on the worm algorithm, we
study the thermodynamic behavior of the S=1/2 isotropic Heisenberg
antiferromagnet on the square lattice in a uniform magnetic field varying from
very small values up to the saturation value. The field is found to induce a
Berezinskii-Kosterlitz-Thouless transition at a finite temperature, above which
a genuine XY behavior in an extended temperature range is observed. The phase
diagram of the system is drawn, and the thermodynamic behavior of the specific
heat and of the uniform and staggered magnetization is discussed in sight of an
experimental investigation of the field-induced XY behavior.Comment: 4 pages, 4 figure
Scaling critical behavior of superconductors at zero magnetic field
We consider the scaling behavior in the critical domain of superconductors at
zero external magnetic field. The first part of the paper is concerned with the
Ginzburg-Landau model in the zero magnetic field Meissner phase. We discuss the
scaling behavior of the superfluid density and we give an alternative proof of
Josephson's relation for a charged superfluid. This proof is obtained as a
consequence of an exact renormalization group equation for the photon mass. We
obtain Josephson's relation directly in the form , that
is, we do not need to assume that the hyperscaling relation holds. Next, we
give an interpretation of a recent experiment performed in thin films of
. We argue that the measured mean field like
behavior of the penetration depth exponent is possibly associated with a
non-trivial critical behavior and we predict the exponents and
for the correlation lenght and specific heat, respectively. In the
second part of the paper we discuss the scaling behavior in the continuum dual
Ginzburg-Landau model. After reviewing lattice duality in the Ginzburg-Landau
model, we discuss the continuum dual version by considering a family of
scalings characterized by a parameter introduced such that
, where is the bare mass of the magnetic
induction field. We discuss the difficulties in identifying the renormalized
magnetic induction mass with the photon mass. We show that the only way to have
a critical regime with is having , that
is, with having the scaling behavior of the renormalized photon mass.Comment: RevTex, 15 pages, no figures; the subsection III-C has been removed
due to a mistak
Reproducibility and intratumoral heterogeneity of the PAM50 breast cancer assay
Background: The PAM50 assay is used routinely in clinical practice to determine breast cancer prognosis and management; however, research assessing how technical variation and intratumoral heterogeneity contribute to misclassification and reproducibility of these tests is limited. Methods: We evaluated the impact of intratumoral heterogeneity on the reproducibility of results for the PAM50 assay by testing RNA extracted from formalin-fixed paraffin embedded breast cancer blocks sampled at distinct spatial locations. Samples were classified according to intrinsic subtype (Luminal A, Luminal B, HER2-enriched, Basal-like, or Normal-like) and risk of recurrence with proliferation score (ROR-P, high, medium, or low). Intratumoral heterogeneity and technical reproducibility (replicate assays on the same RNA) were assessed as percent categorical agreement between paired intratumoral and replicate samples. Euclidean distances between samples, calculated across the PAM50 genes and the ROR-P score, were compared for concordant vs. discordant samples. Results: Technical replicates (N = 144) achieved 93% agreement for ROR-P group and 90% agreement on PAM50 subtype. For spatially distinct biological replicates (N = 40 intratumoral replicates), agreement was lower (81% for ROR-P and 76% for PAM50 subtype). The Euclidean distances between discordant technical replicates were bimodal, with discordant samples showing higher Euclidian distance and biologic heterogeneity. Conclusion: The PAM50 assay achieved very high technical reproducibility for breast cancer subtyping and ROR-P, but intratumoral heterogeneity is revealed by the assay in a small proportion of cases
Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance
AbstractMany different definitions for multidrug-resistant (MDR), extensively drug-resistant (XDR) and pandrug-resistant (PDR) bacteria are being used in the medical literature to characterize the different patterns of resistance found in healthcare-associated, antimicrobial-resistant bacteria. A group of international experts came together through a joint initiative by the European Centre for Disease Prevention and Control (ECDC) and the Centers for Disease Control and Prevention (CDC), to create a standardized international terminology with which to describe acquired resistance profiles in Staphylococcus aureus, Enterococcus spp., Enterobacteriaceae (other than Salmonella and Shigella), Pseudomonas aeruginosa and Acinetobacter spp., all bacteria often responsible for healthcare-associated infections and prone to multidrug resistance. Epidemiologically significant antimicrobial categories were constructed for each bacterium. Lists of antimicrobial categories proposed for antimicrobial susceptibility testing were created using documents and breakpoints from the Clinical Laboratory Standards Institute (CLSI), the European Committee on Antimicrobial Susceptibility Testing (EUCAST) and the United States Food and Drug Administration (FDA). MDR was defined as acquired non-susceptibility to at least one agent in three or more antimicrobial categories, XDR was defined as non-susceptibility to at least one agent in all but two or fewer antimicrobial categories (i.e. bacterial isolates remain susceptible to only one or two categories) and PDR was defined as non-susceptibility to all agents in all antimicrobial categories. To ensure correct application of these definitions, bacterial isolates should be tested against all or nearly all of the antimicrobial agents within the antimicrobial categories and selective reporting and suppression of results should be avoided
Anomalous dimensions and phase transitions in superconductors
The anomalous scaling in the Ginzburg-Landau model for the superconducting
phase transition is studied. It is argued that the negative sign of the
exponent is a consequence of a special singular behavior in momentum space. The
negative sign of comes from the divergence of the critical correlation
function at finite distances. This behavior implies the existence of a Lifshitz
point in the phase diagram. The anomalous scaling of the vector potential is
also discussed. It is shown that the anomalous dimension of the vector
potential has important consequences for the critical dynamics in
superconductors. The frequency-dependent conductivity is shown to obey the
scaling . The prediction is
obtained from existing Monte Carlo data.Comment: RevTex, 20 pages, no figures; small changes; version accepted in PR
Baryon polarization in low-energy unpolarized meson-baryon scattering
We compute the polarization of the final-state baryon, in its rest frame, in
low-energy meson--baryon scattering with unpolarized initial state, in
Unitarized BChPT. Free parameters are determined by fitting total and
differential cross-section data (and spin-asymmetry or polarization data if
available) for , and scattering. We also compare our
results with those of leading-order BChPT
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