Coping with loss: cell adaptation to cytoskeleton disruption

Unravelling the role of cytoskeleton regulators may be complicated by adaptations to experimental manipulations. In this issue of Developmental Cell, Cerikan et al. (2016) reveal how acute effects of DOCK6 RhoGEF depletion on RAC1 and CDC42 activation are reversed over time by compensatory mechanisms that re-establish cellular homeostasis

THEME OVERVIEW: FUNDAMENTAL FORCES AFFECTING AGRIBUSINESS INDUSTRIES

Agribusiness, Market Forces, Structural Change, Porter’s Five Forces, Community/Rural/Urban Development, Q13, L10, L22, M22, L80,

MARKET FORCES AND CHANGES IN THE PLANT INPUT SUPPLY INDUSTRY

Agribusiness, Input Supply Industry, Fertilizer, Plant Nutrients, Seed, Capital, Market Forces, Structural Change, Porter’s Five Forces, Agribusiness, Q13, L10, L22, M22, L80,

LINKAGES BETWEEN FARM AND FINANCIAL MANAGEMENT

Agricultural Finance, Farm Management,

Heat transfer in a compact tubular heat exchanger with helium gas at 3.5 MPa

A compact heat exchanger was constructed consisting of circular tubes in parallel brazed to a grooved base plate. This tube specimen heat exchanger was tested in an apparatus which radiatively heated the specimen on one side at a heat flux of up to 54 W/sq cm, and cooled the specimen with helium gas at 3.5 MPa and Reynolds numbers of 3000 to 35,000. The measured friction factor of the tube specimen was lower than that of a circular tube with fully developed turbulent flow, although the uncertainty was high due to entrance and exit losses. The measured Nusselt number, when modified to account for differences in fluid properties between the wall and the cooling fluid, agreed with past correlations for fully developed turbulent flow in circular tubes

Towards a Measurement of Free Riding within Private Collective Action Organizations

The objective of this study is to determine if there is a dominant free riding activity which can be identified and used as the basis for measuring free riding, or if multiple free riding actions and/or behaviors coexist within large collective action organizations. The study uses a confirmatory factor analysis model to evaluate member level survey data from a large agricultural marketing cooperative.Institutional and Behavioral Economics, Marketing, Research Methods/ Statistical Methods,

Creation of the Myth The Lived Experience of Native Americans in Schools

Native Americans are one of the lowest preforming racial groups in the United States public education system. Native Americans have among the lowest graduation rates, low post-secondary attendance, and are overly represented in special education. A review of the literature provides insights on the dynamics of academic oppression. This research attempts to add to a great deal of quantitative research on different forces of oppression by providing the daily lived experience of Native American youth attending public schools in the United States, which has not been fully researched. The purpose of this study was to answer the question: what is the lived experience of Native Americans who went through the United States mainstream public education system? Five participants were interviewed and analyzed through an analytic induction process. Themes of connection to culture, meaning of being Native American, silencing of culture, exclusion, stereotypes, racial aggressions, family, resilience, transformative experiences, views on Indian Education, and suggestions for social workers were explored. Implications and suggestions for future research are discussed

ROCK signalling induced gene expression changes in mouse pancreatic ductal adenocarcinoma cells

The RhoA and RhoC GTPases act via the ROCK1 and ROCK2 kinases to promote actomyosin contraction, resulting in directly induced changes in cytoskeleton structures and altered gene transcription via several possible indirect routes. Elevated activation of the Rho/ROCK pathway has been reported in several diseases and pathological conditions, including disorders of the central nervous system, cardiovascular dysfunctions and cancer. To determine how increased ROCK signalling affected gene expression in pancreatic ductal adenocarcinoma (PDAC) cells, we transduced mouse PDAC cell lines with retroviral constructs encoding fusion proteins that enable conditional activation of ROCK1 or ROCK2, and subsequently performed RNA sequencing (RNA-Seq) using the Illumina NextSeq 500 platform. We describe how gene expression datasets were generated and validated by comparing data obtained by RNA-Seq with RT-qPCR results. Activation of ROCK1 or ROCK2 signalling induced significant changes in gene expression that could be used to determine how actomyosin contractility influences gene transcription in pancreatic cancer

Creation of the Myth The Lived Experience of Native Americans in Schools

Native Americans are one of the lowest preforming racial groups in the United States public education system. Native Americans have among the lowest graduation rates, low post-secondary attendance, and are overly represented in special education. A review of the literature provides insights on the dynamics of academic oppression. This research attempts to add to a great deal of quantitative research on different forces of oppression by providing the daily lived experience of Native American youth attending public schools in the United States, which has not been fully researched. The purpose of this study was to answer the question: what is the lived experience of Native Americans who went through the United States mainstream public education system? Five participants were interviewed and analyzed through an analytic induction process. Themes of connection to culture, meaning of being Native American, silencing of culture, exclusion, stereotypes, racial aggressions, family, resilience, transformative experiences, views on Indian Education, and suggestions for social workers were explored. Implications and suggestions for future research are discussed